| REVEL: an ensemble method for predicting the pathogenicity of rare missense variants NM Ioannidis, JH Rothstein, V Pejaver, S Middha, SK McDonnell, ... The American Journal of Human Genetics 99 (4), 877-885, 2016 | 2155 | 2016 |
| Germline Mutations in HOXB13 and Prostate-Cancer Risk CM Ewing, AM Ray, EM Lange, KA Zuhlke, CM Robbins, WD Tembe, ... New England Journal of Medicine 366 (2), 141-149, 2012 | 837 | 2012 |
| Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction R Do, NO Stitziel, HH Won, AB Jørgensen, S Duga, P Angelica Merlini, ... Nature 518 (7537), 102-106, 2015 | 784 | 2015 |
| Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array RA Eeles, AAA Olama, S Benlloch, EJ Saunders, DA Leongamornlert, ... Nature genetics 45 (4), 385-391, 2013 | 690 | 2013 |
| Rare and low-frequency coding variants alter human adult height E Marouli, M Graff, C Medina-Gomez, KS Lo, AR Wood, TR Kjaer, RS Fine, ... Nature 542 (7640), 186-190, 2017 | 682 | 2017 |
| Inherited causes of clonal haematopoiesis in 97,691 whole genomes AG Bick, JS Weinstock, SK Nandakumar, CP Fulco, EL Bao, SM Zekavat, ... Nature 586 (7831), 763-768, 2020 | 551 | 2020 |
| Identification of seven new prostate cancer susceptibility loci through a genome-wide association study RA Eeles, Z Kote-Jarai, AA Al Olama, GG Giles, M Guy, G Severi, K Muir, ... Nature genetics 41 (10), 1116-1121, 2009 | 490 | 2009 |
| Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk J Xu, SL Zheng, A Komiya, JC Mychaleckyj, SD Isaacs, JJ Hu, D Sterling, ... Nature genetics 32 (2), 321-325, 2002 | 457 | 2002 |
| Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity V Turcot, Y Lu, HM Highland, C Schurmann, AE Justice, RS Fine, ... Nature genetics 50 (1), 26-41, 2018 | 365 | 2018 |
| Genetic modifiers of liver disease in cystic fibrosis JR Bartlett, KJ Friedman, SC Ling, RG Pace, SC Bell, B Bourke, ... Jama 302 (10), 1076-1083, 2009 | 353 | 2009 |
| Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events LA Lange, CS Carlson, LA Hindorff, EM Lange, J Walston, JP Durda, ... Jama 296 (22), 2703-2711, 2006 | 340 | 2006 |
| The Finland–United States investigation of non–insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes S Ghosh, RM Watanabe, TT Valle, ER Hauser, VL Magnuson, ... The American Journal of Human Genetics 67 (5), 1174-1185, 2000 | 309 | 2000 |
| Exploring the genetic basis of chronic periodontitis: a genome-wide association study K Divaris, KL Monda, KE North, AF Olshan, LM Reynolds, WC Hsueh, ... Human molecular genetics 22 (11), 2312-2324, 2013 | 293 | 2013 |
| Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13. 2 FA Wright, LJ Strug, VK Doshi, CW Commander, SM Blackman, L Sun, ... Nature genetics 43 (6), 539-546, 2011 | 291 | 2011 |
| Prostate cancer susceptibility locus on chromosome 1q: a confirmatory study KA Cooney, L Huang, HM Sandler, E Lange, K Lange, S Miesfeldt, ... Journal of the National Cancer Institute 89 (13), 955-959, 1997 | 280 | 1997 |
| HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG) J Xu, EM Lange, L Lu, SL Zheng, Z Wang, SN Thibodeau, ... Human genetics 132, 5-14, 2013 | 250 | 2013 |
| Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol LA Lange, Y Hu, H Zhang, C Xue, EM Schmidt, ZZ Tang, C Bizon, ... The American Journal of Human Genetics 94 (2), 233-245, 2014 | 245 | 2014 |
| Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility J Wessel, AY Chu, SM Willems, S Wang, H Yaghootkar, JA Brody, ... Nature communications 6 (1), 5897, 2015 | 236 | 2015 |
| Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate … AJ Szalai, J Wu, EM Lange, MA McCrory, CD Langefeld, A Williams, ... Journal of Molecular Medicine 83, 440-447, 2005 | 230 | 2005 |
| Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer TR Smith, MS Miller, K Lohman, EM Lange, LD Case, HW Mohrenweiser, ... Cancer letters 190 (2), 183-190, 2003 | 226 | 2003 |
