The emerging role of systems biology for engineering protein production in CHO cells CC Kuo, AWT Chiang, I Shamie, M Samoudi, JM Gutierrez, NE Lewis Current opinion in biotechnology 51, 64-69, 2018 | 105 | 2018 |
Multiplex secretome engineering enhances recombinant protein production and purity S Kol, D Ley, T Wulff, M Decker, J Arnsdorf, S Schoffelen, AH Hansen, ... Nature communications 11 (1), 1908, 2020 | 94 | 2020 |
Increasing consensus of context-specific metabolic models by integrating data-inferred cell functions A Richelle, AWT Chiang, CC Kuo, NE Lewis PLoS computational biology 15 (4), e1006867, 2019 | 75 | 2019 |
ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis RJ Weiss, PN Spahn, AG Toledo, AWT Chiang, BP Kellman, J Li, ... Proceedings of the National Academy of Sciences 117 (17), 9311-9317, 2020 | 47 | 2020 |
Non-protective immune imprint underlies failure of Staphylococcus aureus IsdB vaccine CM Tsai, JR Caldera, IA Hajam, AWT Chiang, CH Tsai, H Li, ML Díez, ... Cell host & microbe 30 (8), 1163-1172. e6, 2022 | 41 | 2022 |
Elucidating Human Milk Oligosaccharide biosynthetic genes through network-based multi-omics integration BP Kellman, A Richelle, JY Yang, D Chapla, AWT Chiang, JA Najera, ... Nature Communications 13 (1), 2455, 2022 | 41 | 2022 |
Increased production of LIGHT by T cells in eosinophilic esophagitis promotes differentiation of esophageal fibroblasts toward an inflammatory phenotype MC Manresa, AWT Chiang, RC Kurten, R Dohil, H Brickner, L Dohil, ... Gastroenterology 159 (5), 1778-1792. e13, 2020 | 37 | 2020 |
Correcting for sparsity and interdependence in glycomics by accounting for glycan biosynthesis B Bao, BP Kellman, AWT Chiang, Y Zhang, JT Sorrentino, AK York, ... Nature Communications 12 (1), 1-14, 2021 | 36* | 2021 |
Modulating carbohydrate–protein interactions through glycoengineering of monoclonal antibodies to impact cancer physiology AWT Chiang, S Li, PN Spahn, A Richelle, CC Kuo, M Samoudi, NE Lewis Current opinion in structural biology 40, 104-111, 2016 | 29 | 2016 |
Model-based assessment of mammalian cell metabolic functionalities using omics data A Richelle, BP Kellman, AT Wenzel, AWT Chiang, T Reagan, ... Cell Reports Methods 1 (3), 100040, 2021 | 24 | 2021 |
Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate RJ Weiss, PN Spahn, AWT Chiang, Q Liu, J Li, KM Hamill, S Rother, ... Nature Chemical Biology 17 (6), 684-692, 2021 | 22 | 2021 |
A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering C Liang, AWT Chiang, AH Hansen, J Arnsdorf, S Schoffelen, ... Current research in biotechnology 2, 22-36, 2020 | 22 | 2020 |
Understanding system dynamics of an adaptive enzyme network from globally profiled kinetic parameters AWT Chiang, WC Liu, P Charusanti, MJ Hwang BMC systems biology 8 (1), 1-12, 2014 | 22 | 2014 |
A unique esophageal extracellular matrix proteome alters normal fibroblast function in severe eosinophilic esophagitis LY Hsieh, AWT Chiang, LD Duong, CC Kuo, SX Dong, R Dohil, R Kurten, ... Journal of Allergy and Clinical Immunology 148 (2), 486-494, 2021 | 20 | 2021 |
Combating viral contaminants in CHO cells by engineering innate immunity AWT Chiang, S Li, BP Kellman, G Chattopadhyay, Y Zhang, CC Kuo, ... Scientific reports 9 (1), 1-15, 2019 | 18* | 2019 |
A consensus-based and readable extension of Linear Code for Reaction Rules (LiCoRR) BP Kellman, Y Zhang, E Logomasini, E Meinhardt, KP Godinez-Macias, ... Beilstein journal of organic chemistry 16 (1), 2645-2662, 2020 | 17 | 2020 |
Artificial intelligence in the analysis of glycosylation data H Li, AWT Chiang, NE Lewis Biotechnology Advances 60, 108008, 2022 | 16 | 2022 |
Dysregulation of the secretory pathway connects Alzheimer’s disease genetics to aggregate formation CC Kuo, AWT Chiang, HM Baghdassarian, NE Lewis Cell Systems 12 (9), 873-884. e4, 2021 | 15 | 2021 |
Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders AWT Chiang, LD Duong, T Shoda, QM Nhu, M Ruffner, T Hara, B Aaron, ... Journal of Pediatric Gastroenterology and Nutrition 72 (5), 718, 2021 | 13 | 2021 |
LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms MC Manresa, A Wu, QM Nhu, AWT Chiang, K Okamoto, H Miki, R Kurten, ... Mucosal immunology 15 (2), 327-337, 2022 | 12 | 2022 |