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Brendan J. Whittle
Brendan J. Whittle
Professor Emeritus of Applied Pharmacology, William Harvey Research Inst.
在 qmul.ac.uk 的电子邮件经过验证 - 首页
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1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo
EP Garvey, JA Oplinger, ES Furfine, RJ Kiff, F Laszlo, BJR Whittle, ...
Journal of Biological Chemistry 272 (8), 4959-4963, 1997
10141997
Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion.
TB McCALL, NK Boughton-Smith, RM Palmer, BJ Whittle, S Moncada
Biochemical Journal 261 (1), 293, 1989
7381989
Nitric oxide synthase activity in ulcerative colitis and Crohn's disease
NK Boughton-Smith, SM Evans, BJR Whittle, S Moncada, CJ Hawkey, ...
The Lancet 342 (8867), 338-e2, 1993
5941993
Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat.
BJ Whittle, J Lopez-Belmonte, S Moncada
British journal of pharmacology 99 (3), 607, 1990
5821990
Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat
BJR Whittle
Gastroenterology 80 (1), 94-98, 1981
5341981
Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa
BJR Whittle, GA Higgs, KE Eakins, S Moncada, JR Vane
Nature 284 (5753), 271-273, 1980
4921980
Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat.
IR Hutcheson, BJ Whittle, NK Boughton-Smith
British journal of pharmacology 101 (4), 815, 1990
4551990
Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species
BJR Whittle, S Moncada, JR Vane
Prostaglandins 16 (3), 373-388, 1978
4141978
The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat.
NK Boughton-Smith, SM Evans, F Laszlo, BJ Whittle, S Moncada
British journal of pharmacology 110 (3), 1189, 1993
3601993
Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition
P Pizcueta, JM Piqué, M Fernández, J Bosch, J Rodés, BJR Whittle, ...
Gastroenterology 103 (6), 1909-1915, 1992
3501992
Mechanisms underlying gastric mucosal damage induced by indomethacin and bile-salts, and the actions of prostaglandins.
BJ Whittle
British journal of pharmacology 60 (3), 455, 1977
3371977
Modulation of the vasodepressor actions of acetylcholine, bradykinin, substance P and endothelin in the rat by a specific inhibitor of nitric oxide formation.
BJ Whittle, J Lopez-Belmonte, DD Rees
British journal of pharmacology 98 (2), 646, 1989
3351989
Nitric oxide synthase induction and intestinal epithelial cell viability in rats
BL Tepperman, JF Brown, BJ Whittle
American Journal of Physiology-Gastrointestinal and Liver Physiology 265 (2 …, 1993
3031993
Potent ulcerogenic actions of platelet-activating factor on the stomach
AC Rosam, JL Wallace, BJR Whittle
Nature 319 (6048), 54-56, 1986
2991986
Effects of inhibiting nitric oxide biosynthesis on the systemic and splanchnic circulation of rats with portal hypertension.
MP Pizcueta, JM Piqué, J Bosch, BJ Whittle, S Moncada
British journal of pharmacology 105 (1), 184, 1992
2981992
Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells
JF Brown, AC Keates, PJ Hanson, BJ Whittle
American Journal of Physiology-Gastrointestinal and Liver Physiology 265 (3 …, 1993
2841993
The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation
JM Pique, BJR Whittle, JV Esplugues
European journal of pharmacology 174 (2-3), 293-296, 1989
2831989
Gastrointestinal effects of nonsteroidal anti‐inflammatory drugs
BJR Whittle
Fundamental & clinical pharmacology 17 (3), 301-313, 2003
2612003
The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa
J Lopez‐Belmonte, BJR Whittle, S Moncada
British journal of pharmacology 108 (1), 73-78, 1993
2611993
Investigation of the vasodilator and antisecretory role of prostaglandins in the rat gastric mucosa by use of non-steroidal anti-inflammatory drugs.
IH Main, BJ Whittle
British journal of pharmacology 53 (2), 217, 1975
2471975
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