1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo EP Garvey, JA Oplinger, ES Furfine, RJ Kiff, F Laszlo, BJR Whittle, ... Journal of Biological Chemistry 272 (8), 4959-4963, 1997 | 1014 | 1997 |
Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion. TB McCALL, NK Boughton-Smith, RM Palmer, BJ Whittle, S Moncada Biochemical Journal 261 (1), 293, 1989 | 738 | 1989 |
Nitric oxide synthase activity in ulcerative colitis and Crohn's disease NK Boughton-Smith, SM Evans, BJR Whittle, S Moncada, CJ Hawkey, ... The Lancet 342 (8867), 338-e2, 1993 | 594 | 1993 |
Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat. BJ Whittle, J Lopez-Belmonte, S Moncada British journal of pharmacology 99 (3), 607, 1990 | 582 | 1990 |
Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat BJR Whittle Gastroenterology 80 (1), 94-98, 1981 | 534 | 1981 |
Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa BJR Whittle, GA Higgs, KE Eakins, S Moncada, JR Vane Nature 284 (5753), 271-273, 1980 | 492 | 1980 |
Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat. IR Hutcheson, BJ Whittle, NK Boughton-Smith British journal of pharmacology 101 (4), 815, 1990 | 455 | 1990 |
Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species BJR Whittle, S Moncada, JR Vane Prostaglandins 16 (3), 373-388, 1978 | 414 | 1978 |
The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat. NK Boughton-Smith, SM Evans, F Laszlo, BJ Whittle, S Moncada British journal of pharmacology 110 (3), 1189, 1993 | 360 | 1993 |
Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition P Pizcueta, JM Piqué, M Fernández, J Bosch, J Rodés, BJR Whittle, ... Gastroenterology 103 (6), 1909-1915, 1992 | 350 | 1992 |
Mechanisms underlying gastric mucosal damage induced by indomethacin and bile-salts, and the actions of prostaglandins. BJ Whittle British journal of pharmacology 60 (3), 455, 1977 | 337 | 1977 |
Modulation of the vasodepressor actions of acetylcholine, bradykinin, substance P and endothelin in the rat by a specific inhibitor of nitric oxide formation. BJ Whittle, J Lopez-Belmonte, DD Rees British journal of pharmacology 98 (2), 646, 1989 | 335 | 1989 |
Nitric oxide synthase induction and intestinal epithelial cell viability in rats BL Tepperman, JF Brown, BJ Whittle American Journal of Physiology-Gastrointestinal and Liver Physiology 265 (2 …, 1993 | 303 | 1993 |
Potent ulcerogenic actions of platelet-activating factor on the stomach AC Rosam, JL Wallace, BJR Whittle Nature 319 (6048), 54-56, 1986 | 299 | 1986 |
Effects of inhibiting nitric oxide biosynthesis on the systemic and splanchnic circulation of rats with portal hypertension. MP Pizcueta, JM Piqué, J Bosch, BJ Whittle, S Moncada British journal of pharmacology 105 (1), 184, 1992 | 298 | 1992 |
Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells JF Brown, AC Keates, PJ Hanson, BJ Whittle American Journal of Physiology-Gastrointestinal and Liver Physiology 265 (3 …, 1993 | 284 | 1993 |
The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation JM Pique, BJR Whittle, JV Esplugues European journal of pharmacology 174 (2-3), 293-296, 1989 | 283 | 1989 |
Gastrointestinal effects of nonsteroidal anti‐inflammatory drugs BJR Whittle Fundamental & clinical pharmacology 17 (3), 301-313, 2003 | 261 | 2003 |
The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa J Lopez‐Belmonte, BJR Whittle, S Moncada British journal of pharmacology 108 (1), 73-78, 1993 | 261 | 1993 |
Investigation of the vasodilator and antisecretory role of prostaglandins in the rat gastric mucosa by use of non-steroidal anti-inflammatory drugs. IH Main, BJ Whittle British journal of pharmacology 53 (2), 217, 1975 | 247 | 1975 |