Pro‐arrhythmogenic effects of atrial fibrillation‐induced electrical remodelling: insights from the three‐dimensional virtual human atria MA Colman, OV Aslanidi, S Kharche, MR Boyett, C Garratt, JC Hancox, ... The Journal of physiology 591 (17), 4249-4272, 2013 | 150 | 2013 |
A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases S Kharche, J Yu, M Lei, H Zhang American Journal of Physiology-Heart and circulatory physiology 301 (3 …, 2011 | 82 | 2011 |
Repolarisation and vulnerability to re-entry in the human heart with short QT syndrome arising from KCNQ1 mutation—A simulation study H Zhang, S Kharche, AV Holden, JC Hancox Progress in biophysics and molecular biology 96 (1-3), 112-131, 2008 | 80 | 2008 |
Atrial proarrhythmia due to increased inward rectifier current (IK1) arising from KCNJ2 mutation–a simulation study S Kharche, CJ Garratt, MR Boyett, S Inada, AV Holden, JC Hancox, ... Progress in biophysics and molecular biology 98 (2-3), 186-197, 2008 | 79 | 2008 |
Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein expression in ventricular muscle FC Howarth, NJ Chandler, S Kharche, JO Tellez, ID Greener, ... Molecular and cellular biochemistry 319, 105-114, 2008 | 58 | 2008 |
Pro‐arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation – insights from modelling S Kharche, I Adeniran, J Stott, P Law, MR Boyett, JC Hancox, H Zhang The Journal of physiology 590 (18), 4501-4514, 2012 | 46 | 2012 |
BeatBox—HPC simulation environment for biophysically and anatomically realistic cardiac electrophysiology M Antonioletti, VN Biktashev, A Jackson, SR Kharche, T Stary, ... PloS one 12 (5), e0172292, 2017 | 36 | 2017 |
Marine n-3 PUFAs modulate IKs gating, channel expression, and location in membrane microdomains C Moreno, A de La Cruz, A Oliveras, SR Kharche, M Guizy, N Comes, ... Cardiovascular Research 105 (2), 223-232, 2015 | 35 | 2015 |
Steering and visualization: Enabling technologies for computational science H Wright, RH Crompton, S Kharche, P Wenisch Future Generation Computer Systems 26 (3), 506-513, 2010 | 34 | 2010 |
Computational assessment of the functional role of sinoatrial node exit pathways in the human heart SR Kharche, E Vigmond, IR Efimov, H Dobrzynski PloS one 12 (9), e0183727, 2017 | 33 | 2017 |
Virtual tissue engineering of the human atrium: modelling pharmacological actions on atrial arrhythmogenesis OV Aslanidi, M Al-Owais, AP Benson, M Colman, CJ Garratt, SH Gilbert, ... European Journal of Pharmaceutical Sciences 46 (4), 209-221, 2012 | 31 | 2012 |
Optimization of catheter ablation of atrial fibrillation: insights gained from clinically-derived computer models J Zhao, SR Kharche, BJ Hansen, TA Csepe, Y Wang, MK Stiles, ... International journal of molecular sciences 16 (5), 10834-10854, 2015 | 29 | 2015 |
Simulation of clinical electrophysiology in 3D human atria: a high‐performance computing and high‐performance visualization application S Kharche, G Seemann, L Margetts, J Leng, AV Holden, H Zhang Concurrency and Computation: Practice and Experience 20 (11), 1317-1328, 2008 | 27 | 2008 |
A computer simulation study of anatomy induced drift of spiral waves in the human atrium SR Kharche, IV Biktasheva, G Seemann, H Zhang, VN Biktashev BioMed research international 2015 (1), 731386, 2015 | 26 | 2015 |
Effects of human atrial ionic remodelling by β-blocker therapy on mechanisms of atrial fibrillation: a computer simulation SR Kharche, T Stary, MA Colman, IV Biktasheva, AJ Workman, AC Rankin, ... Europace 16 (10), 1524-1533, 2014 | 26 | 2014 |
Simulating the effects of atrial fibrillation induced electrical remodeling: a comprehensive simulation study S Kharche, H Zhang 2008 30th Annual International Conference of the IEEE Engineering in …, 2008 | 25 | 2008 |
Mechanisms underlying adaptation of action potential duration by pacing rate in rat myocytes L Sallé, S Kharche, H Zhang, F Brette Progress in biophysics and molecular biology 96 (1-3), 305-320, 2008 | 25 | 2008 |
Endogenous driving and synchronization in cardiac and uterine virtual tissues: bifurcations and local coupling AP Benson, RH Clayton, AV Holden, S Kharche, WC Tong Philosophical Transactions of the Royal Society A: Mathematical, Physical …, 2006 | 23 | 2006 |
A robust computational framework for estimating 3D Bi-Atrial chamber wall thickness Y Wang, Z Xiong, A Nalar, BJ Hansen, S Kharche, G Seemann, A Loewe, ... Computers in biology and medicine 114, 103444, 2019 | 22 | 2019 |
Scroll waves in 3D virtual human atria: a computational study S Kharche, G Seemann, J Leng, AV Holden, CJ Garratt, H Zhang Functional Imaging and Modeling of the Heart: 4th International Conference …, 2007 | 22 | 2007 |