| The anaplastic lymphoma kinase in the pathogenesis of cancer R Chiarle, C Voena, C Ambrogio, R Piva, G Inghirami Nature Reviews Cancer 8 (1), 11-23, 2008 | 1027 | 2008 |
| KRAS dimerization impacts MEK inhibitor sensitivity and oncogenic activity of mutant KRAS C Ambrogio, J Köhler, ZW Zhou, H Wang, R Paranal, J Li, M Capelletti, ... Cell 172 (4), 857-868. e15, 2018 | 265 | 2018 |
| Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology RB Blasco, E Karaca, C Ambrogio, TC Cheong, E Karayol, VG Minero, ... Cell reports 9 (4), 1219-1227, 2014 | 240 | 2014 |
| Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma C Ambrogio, G Gomez-Lopez, M Falcone, A Vidal, E Nadal, N Crosetto, ... Nature medicine 22 (3), 270-277, 2016 | 187 | 2016 |
| Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas R Piva, R Chiarle, AD Manazza, R Taulli, W Simmons, C Ambrogio, ... Blood 107 (2), 689-697, 2006 | 178 | 2006 |
| Potent and selective covalent quinazoline inhibitors of KRAS G12C M Zeng, J Lu, L Li, F Feru, C Quan, TW Gero, SB Ficarro, Y Xiong, ... Cell chemical biology 24 (8), 1005-1016. e3, 2017 | 139 | 2017 |
| MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling P Gonzalo, MC Guadamillas, MV Hernández-Riquer, Á Pollán, ... Developmental cell 18 (1), 77-89, 2010 | 136 | 2010 |
| The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination R Chiarle, C Martinengo, C Mastini, C Ambrogio, V D'escamard, G Forni, ... Nature medicine 14 (6), 676-680, 2008 | 134 | 2008 |
| Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells M Compagno, Q Wang, C Pighi, TC Cheong, FL Meng, T Poggio, ... Nature 542 (7642), 489-493, 2017 | 129 | 2017 |
| The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration C Voena, C Conte, C Ambrogio, E Boeri Erba, F Boccalatte, S Mohammed, ... Cancer research 67 (9), 4278-4286, 2007 | 127 | 2007 |
| NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells C Ambrogio, C Martinengo, C Voena, F Tondat, L Riera, PF di Celle, ... Cancer research 69 (22), 8611-8619, 2009 | 113 | 2009 |
| A Braf kinase-inactive mutant induces lung adenocarcinoma P Nieto, C Ambrogio, L Esteban-Burgos, G Gómez-López, MT Blasco, ... Nature 548 (7666), 239-243, 2017 | 106 | 2017 |
| Impact of BRAF mutation class on disease characteristics and clinical outcomes in BRAF-mutant lung cancer I Dagogo-Jack, P Martinez, BY Yeap, C Ambrogio, LA Ferris, C Lydon, ... Clinical Cancer Research 25 (1), 158-165, 2019 | 104 | 2019 |
| p130Cas mediates the transforming properties of the anaplastic lymphoma kinase C Ambrogio, C Voena, AD Manazza, R Piva, L Riera, L Barberis, C Costa, ... Blood 106 (12), 3907-3916, 2005 | 100 | 2005 |
| Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner N Crosetto, M Bienko, RG Hibbert, T Perica, C Ambrogio, T Kensche, ... Journal of biological chemistry 283 (50), 35173-35185, 2008 | 81 | 2008 |
| Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice AJ Lopez-Contreras, J Specks, JH Barlow, C Ambrogio, C Desler, ... Genes & development 29 (7), 690-695, 2015 | 78 | 2015 |
| Selective therapeutic targeting of the anaplastic lymphoma kinase with liposomal siRNA induces apoptosis and inhibits angiogenesis in neuroblastoma D Di Paolo, C Ambrogio, F Pastorino, C Brignole, C Martinengo, ... Molecular Therapy 19 (12), 2201-2212, 2011 | 77 | 2011 |
| Leukocyte transmigration is modulated by chemokine‐mediated PI3Kγ‐dependent phosphorylation of vimentin L Barberis, C Pasquali, D Bertschy‐Meier, A Cuccurullo, C Costa, ... European journal of immunology 39 (4), 1136-1146, 2009 | 77 | 2009 |
| The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation C Ambrogio, C Voena, AD Manazza, C Martinengo, C Costa, ... Cancer research 68 (21), 8899-8907, 2008 | 76 | 2008 |
| Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase γ C Costa, L Barberis, C Ambrogio, AD Manazza, E Patrucco, O Azzolino, ... Proceedings of the National Academy of Sciences 104 (36), 14354-14359, 2007 | 75 | 2007 |
