| The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells M Paolino, A Choidas, S Wallner, B Pranjic, I Uribesalgo, S Loeser, ... Nature 507 (7493), 508-512, 2014 | 472 | 2014 |
| A dual role for autophagy in a murine model of lung cancer. Nat Commun 2014 5 (3056), 2014 | 442 | 2014 |
| In vivo CRISPR editing with no detectable genome-wide off-target mutations P Akcakaya, ML Bobbin, JA Guo, J Malagon-Lopez, K Clement, SP Garcia, ... Nature 561 (7723), 416-419, 2018 | 344 | 2018 |
| The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription T Di Palma, R Nitsch, A Mascia, L Nitsch, R Di Lauro, M Zannini Journal of Biological Chemistry 278 (5), 3395-3402, 2003 | 174 | 2003 |
| Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes M Daugaard, R Nitsch, B Razaghi, L McDonald, A Jarrar, S Torrino, ... Nature communications 4 (1), 2180, 2013 | 111 | 2013 |
| CRISPR-UMI: single-cell lineage tracing of pooled CRISPR–Cas9 screens G Michlits, M Hubmann, SH Wu, G Vainorius, E Budusan, S Zhuk, ... Nature methods 14 (12), 1191-1197, 2017 | 110 | 2017 |
| HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response B Rotblat, AL Southwell, DE Ehrnhoefer, NH Skotte, M Metzler, ... Proceedings of the National Academy of Sciences 111 (8), 3032-3037, 2014 | 108 | 2014 |
| Decoding non-random mutational signatures at Cas9 targeted sites A Taheri-Ghahfarokhi, BJM Taylor, R Nitsch, A Lundin, AL Cavallo, ... Nucleic acids research 46 (16), 8417-8434, 2018 | 95 | 2018 |
| In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model A Carreras, LS Pane, R Nitsch, K Madeyski-Bengtson, M Porritt, ... BMC biology 17, 1-14, 2019 | 83 | 2019 |
| Therapeutic genome editing with CRISPR/Cas9 in a humanized mouse model ameliorates α1-antitrypsin deficiency phenotype M Bjursell, MJ Porritt, E Ericson, A Taheri-Ghahfarokhi, M Clausen, ... EBioMedicine 29, 104-111, 2018 | 79 | 2018 |
| The tumor suppressor Hace1 is a critical regulator of TNFR1-mediated cell fate L Tortola, R Nitsch, MJM Bertrand, M Kogler, Y Redouane, I Kozieradzki, ... Cell reports 15 (7), 1481-1492, 2016 | 69 | 2016 |
| CDH16/Ksp-cadherin is expressed in the developing thyroid gland and is strongly down-regulated in thyroid carcinomas G Calì, F Gentile, S Mogavero, P Pallante, R Nitsch, G Ciancia, A Ferraro, ... Endocrinology 153 (1), 522-534, 2012 | 53 | 2012 |
| Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery A Lundin, MJ Porritt, H Jaiswal, F Seeliger, C Johansson, AW Bidar, ... Nature communications 11 (1), 4903, 2020 | 52 | 2020 |
| Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells M Dentice, C Luongo, A Elefante, R Ambrosio, S Salzano, M Zannini, ... Molecular and Cellular Biology, 2005 | 47 | 2005 |
| Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene R Nitsch, V Di Dato, A di Gennaro, T de Cristofaro, S Abbondante, ... BMC genomics 11, 1-13, 2010 | 40 | 2010 |
| RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer S Rao, V Sigl, RA Wimmer, M Novatchkova, A Jais, G Wagner, ... Genes & Development 31 (20), 2099-2112, 2017 | 39 | 2017 |
| WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8 R Nitsch, T Di Palma, A Mascia, M Zannini Biochemical Journal 377 (3), 553-560, 2004 | 37 | 2004 |
| HACE1 deficiency leads to structural and functional neurodevelopmental defects V Nagy, R Hollstein, TP Pai, MK Herde, P Buphamalai, P Moeseneder, ... Neurology: Genetics 5 (3), e330, 2019 | 34 | 2019 |
| Functional inactivation of the transcription factor Pax8 through oligomerization chain reaction B D’Andrea, R Iacone, T Di Palma, R Nitsch, MG Baratta, L Nitsch, ... Molecular Endocrinology 20 (8), 1810-1824, 2006 | 27 | 2006 |
| HACE1 prevents lung carcinogenesis via inhibition of RAC-family GTPases M Kogler, L Tortola, GL Negri, A Leopoldi, AM El-Naggar, S Mereiter, ... Cancer research 80 (14), 3009-3022, 2020 | 23 | 2020 |
