The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase L Pintard, JH Willis, A Willems, JLF Johnson, M Srayko, T Kurz, S Glaser, ... Nature 425 (6955), 311-316, 2003 | 518 | 2003 |
UBQLN2 mediates autophagy-independent protein aggregate clearance by the proteasome R Hjerpe, JS Bett, MJ Keuss, A Solovyova, TG McWilliams, C Johnson, ... Cell 166 (4), 935-949, 2016 | 300 | 2016 |
Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway T Kurz, L Pintard, JH Willis, DR Hamill, P Gönczy, M Peter, B Bowerman Science 295 (5558), 1294-1298, 2002 | 242 | 2002 |
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae T Kurz, N Özlü, F Rudolf, SM O'Rourke, B Luke, K Hofmann, AA Hyman, ... Nature 435 (7046), 1257-1261, 2005 | 234 | 2005 |
The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt … A Ohta, FR Schumacher, Y Mehellou, C Johnson, A Knebel, TJ Macartney, ... Biochemical Journal 451 (1), 111-122, 2013 | 233 | 2013 |
Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation T Kurz, YC Chou, AR Willems, N Meyer-Schaller, ML Hecht, M Tyers, ... Molecular cell 29 (1), 23-35, 2008 | 225 | 2008 |
Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans L Pintard, T Kurz, S Glaser, JH Willis, M Peter, B Bowerman Current Biology 13 (11), 911-921, 2003 | 212 | 2003 |
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes R Hjerpe, Y Thomas, J Chen, A Zemla, S Curran, N Shpiro, LR Dick, ... Biochemical Journal 441 (3), 927-939, 2012 | 129 | 2012 |
A dual E3 mechanism for Rub1 ligation to Cdc53 DC Scott, JK Monda, CRR Grace, DM Duda, RW Kriwacki, T Kurz, ... Molecular cell 39 (5), 784-796, 2010 | 122 | 2010 |
CSN-and CAND1-dependent remodelling of the budding yeast SCF complex A Zemla, Y Thomas, S Kedziora, A Knebel, NT Wood, G Rabut, T Kurz Nature communications 4 (1), 1641, 2013 | 116 | 2013 |
Degrade to create: developmental requirements for ubiquitin-mediated proteolysis during early C. elegans embryogenesis B Bowerman, T Kurz Oxford University Press for The Company of Biologists Limited 133 (5), 773-784, 2006 | 108 | 2006 |
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes N Meyer-Schaller, YC Chou, I Sumara, DDO Martin, T Kurz, N Katheder, ... Proceedings of the National Academy of Sciences 106 (30), 12365-12370, 2009 | 97 | 2009 |
The cullin Rtt101p promotes replication fork progression through damaged DNA and natural pause sites B Luke, G Versini, M Jaquenoud, IW Zaidi, T Kurz, L Pintard, P Pasero, ... Current biology 16 (8), 786-792, 2006 | 97 | 2006 |
Characterisation of the Cullin‐3 mutation that causes a severe form of familial hypertension and hyperkalaemia FR Schumacher, K Siew, J Zhang, C Johnson, N Wood, SE Cleary, ... EMBO molecular medicine 7 (10), 1285-1306, 2015 | 95 | 2015 |
Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation FR Schumacher, FJ Sorrell, DR Alessi, AN Bullock, T Kurz Biochemical Journal 460 (2), 237-246, 2014 | 82 | 2014 |
NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway R Hjerpe, Y Thomas, T Kurz Journal of molecular biology 421 (1), 27-29, 2012 | 65 | 2012 |
WNK signalling pathways in blood pressure regulation M Murthy, T Kurz, KM O’Shaughnessy Cellular and Molecular Life Sciences 74, 1261-1280, 2017 | 53 | 2017 |
Ubiquitin C-terminal hydrolases cleave isopeptide-and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers JS Bett, MS Ritorto, R Ewan, EG Jaffray, S Virdee, JW Chin, A Knebel, ... Biochemical Journal 466 (3), 489-498, 2015 | 51 | 2015 |
The TFIIH subunit Tfb3 regulates cullin neddylation G Rabut, G Le Dez, R Verma, T Makhnevych, A Knebel, T Kurz, C Boone, ... Molecular cell 43 (3), 488-495, 2011 | 49 | 2011 |
Unanchored tri‐NEDD8 inhibits PARP‐1 to protect from oxidative stress‐induced cell death MJ Keuss, R Hjerpe, O Hsia, R Gourlay, R Burchmore, M Trost, T Kurz The EMBO journal 38 (6), e100024, 2019 | 46 | 2019 |