Antisense oligonucleotides targeting angiogenic factors as potential cancer therapeutics BT Le, P Raguraman, TR Kosbar, S Fletcher, SD Wilton, RN Veedu Molecular Therapy-Nucleic Acids 14, 142-157, 2019 | 79 | 2019 |
Evaluation of anhydrohexitol nucleic acid, cyclohexenyl nucleic acid and d-altritol nucleic acid-modified 2′-O-methyl RNA mixmer antisense oligonucleotides for exon skipping … BT Le, S Chen, M Abramov, P Herdewijn, RN Veedu Chemical communications 52 (92), 13467-13470, 2016 | 38 | 2016 |
Rational design of short locked nucleic acid-modified 2′-O-methyl antisense oligonucleotides for efficient exon-skipping in vitro BT Le, AM Adams, S Fletcher, SD Wilton, RN Veedu Molecular Therapy-Nucleic Acids 9, 155-161, 2017 | 36 | 2017 |
Systematic evaluation of 2′-Fluoro modified chimeric antisense oligonucleotide-mediated exon skipping in vitro S Chen, BT Le, M Chakravarthy, TR Kosbar, RN Veedu Scientific Reports 9 (1), 6078, 2019 | 33 | 2019 |
Construction of a bivalent thrombin binding aptamer and its antidote with improved properties QW Hughes, BT Le, G Gilmore, RI Baker, RN Veedu Molecules 22 (10), 1770, 2017 | 29 | 2017 |
Novel Chemically-modified DNAzyme targeting Integrin alpha-4 RNA transcript as a potential molecule to reduce inflammation in multiple sclerosis M Chakravarthy, MT Aung-Htut, BT Le, RN Veedu Scientific reports 7 (1), 1613, 2017 | 29 | 2017 |
Antisense oligonucleotide modified with serinol nucleic acid (SNA) induces exon skipping in mdx myotubes BT Le, K Murayama, F Shabanpoor, H Asanuma, RN Veedu RSC advances 7 (54), 34049-34052, 2017 | 29 | 2017 |
Self-assembling asymmetric peptide-dendrimer micelles – a platform for effective and versatile in vitro nucleic acid delivery GR Kokil, RN Veedu, BT Le, GA Ramm, HS Parekh Scientific Reports 8 (1), 4832, 2018 | 27 | 2018 |
Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing BT Le, S Paul, K Jastrzebska, H Langer, MH Caruthers, RN Veedu Proceedings of the National Academy of Sciences 119 (36), e2207956119, 2022 | 23 | 2022 |
Synthesis of a Morpholino Nucleic Acid (MNA)-Uridine Phosphoramidite, and Exon Skipping Using MNA/2′-O-Methyl Mixmer Antisense Oligonucleotide S Chen, BT Le, K Rahimizadeh, K Shaikh, N Mohal, RN Veedu Molecules 21 (11), 1582, 2016 | 22 | 2016 |
Investigation of twisted intercalating nucleic acid (TINA)-modified antisense oligonucleotides for splice modulation by induced exon-skipping in vitro BT Le, VV Filichev, RN Veedu RSC advances 6 (97), 95169-95172, 2016 | 20 | 2016 |
Nucleobase-modified antisense oligonucleotides containing 5-(phenyltriazol)-2′-deoxyuridine nucleotides induce exon-skipping in vitro BT Le, M Hornum, PK Sharma, P Nielsen, RN Veedu RSC advances 7 (86), 54542-54545, 2017 | 19 | 2017 |
Novel disulfide-bridged bioresponsive antisense oligonucleotide induces efficient splice modulation in muscle myotubes in vitro BT Le, TR Kosbar, RN Veedu ACS omega 5 (29), 18035-18039, 2020 | 11 | 2020 |
Downregulation of vascular endothelial growth factor enhances chemosensitivity by induction of apoptosis in hepatocellular carcinoma cells DC Chung, HN Son, LT Bao Cell Journal (Yakhteh) 17 (2), 273, 2015 | 11 | 2015 |
Evaluation of DNA segments in 2′-modified RNA sequences in designing efficient splice switching antisense oligonucleotides BT Le, S Agarwal, RN Veedu RSC advances 11 (23), 14029-14035, 2021 | 8 | 2021 |
Splice-Modulating Antisense Oligonucleotides as Therapeutics for Inherited Metabolic Diseases RN Chen, S., Heendeniya, S.N., Le, B.T., Rahimizadeh, K., Rabiee, N., Zahra ... BioDrugs, 2024 | 4 | 2024 |
Nanoparticles-assisted aptamer biosensing for the detection of environmental pathogens K Rahimizadeh, Q ul ain Zahra, S Chen, BT Le, I Ullah, RN Veedu Environmental research, 117123, 2023 | 4 | 2023 |
Evaluation of Chemically Modified Nucleic Acid Analogues for Splice Switching Application BT Le, S Chen, RN Veedu ACS omega 8 (51), 48650-48661, 2023 | 1 | 2023 |
Unlocked nucleic acid modified primer-based enzymatic polymerization assay: towards allele-specific genotype detection of human platelet antigens BT Le, Q Hughes, S Rakesh, R Baker, PT Jørgensen, J Wengel, ... RSC advances 8 (57), 32770-32774, 2018 | 1 | 2018 |
Thiomorpholino antisense oligonucleotides for the treatment of PTP1B related diseases M Caruthers, R Veedu, TB Le US Patent App. 63/425,161, 2022 | | 2022 |