Eight prion strains have PrPSc molecules with different conformations J Safar, H Wille, V Itri, D Groth, H Serban, M Torchia, FE Cohen, ... Nature Medicine 4 (10), 1157-1165, 1998 | 1520 | 1998 |
Evidence for assembly of prions with left-handed β-helices into trimers C Govaerts, H Wille, SB Prusiner, FE Cohen Proceedings of the National Academy of Sciences of the United States of …, 2004 | 711 | 2004 |
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains M Vey, S Pilkuhn, H Wille, R Nixon, SJ DeArmond, EJ Smart, ... Proceedings of the National Academy of Sciences 93 (25), 14945-14949, 1996 | 699 | 1996 |
Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro. H Wille, G Drewes, J Biernat, EM Mandelkow, E Mandelkow The Journal of cell biology 118 (3), 573-584, 1992 | 594 | 1992 |
Structural studies of the scrapie prion protein by electron crystallography H Wille, MD Michelitsch, V Guénebaut, S Supattapone, A Serban, ... Proceedings of the National Academy of Sciences 99 (6), 3563-3568, 2002 | 536 | 2002 |
Small-molecule aggregates inhibit amyloid polymerization BY Feng, BH Toyama, H Wille, DW Colby, SR Collins, BCH May, ... Nature chemical biology 4 (3), 197-199, 2008 | 312 | 2008 |
Branched polyamines cure prion-infected neuroblastoma cells S Supattapone, H Wille, L Uyechi, J Safar, P Tremblay, FC Szoka, ... Journal of virology 75 (7), 3453-3461, 2001 | 289 | 2001 |
Natural and synthetic prion structure from X-ray fiber diffraction H Wille, W Bian, M McDonald, A Kendall, DW Colby, L Bloch, J Ollesch, ... Proceedings of the National Academy of Sciences 106 (40), 16990-16995, 2009 | 276 | 2009 |
Cytosolic prion protein in neurons A Mironov Jr, D Latawiec, H Wille, E Bouzamondo-Bernstein, G Legname, ... The Journal of neuroscience 23 (18), 7183-7193, 2003 | 274 | 2003 |
Prion protein of 106 residues creates an artificial transmission barrier for prion replication in transgenic mice S Supattapone, P Bosque, T Muramoto, H Wille, C Aagaard, D Peretz, ... Cell 96 (6), 869-878, 1999 | 269 | 1999 |
Conformational diversity of wild-type Tau fibrils specified by templated conformation change B Frost, J Ollesch, H Wille, MI Diamond Journal of Biological Chemistry 284 (6), 3546-3551, 2009 | 260 | 2009 |
Design and construction of diverse mammalian prion strains DW Colby, K Giles, G Legname, H Wille, IV Baskakov, SJ DeArmond, ... Proceedings of the National Academy of Sciences 106 (48), 20417-20422, 2009 | 252 | 2009 |
α-Synuclein strains target distinct brain regions and cell types A Lau, RWL So, HHC Lau, JC Sang, A Ruiz-Riquelme, SC Fleck, E Stuart, ... Nature Neuroscience 23 (1), 21-31, 2020 | 245 | 2020 |
Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation. T Hagestedt, B Lichtenberg, H Wille, EM Mandelkow, E Mandelkow The Journal of cell biology 109 (4), 1643-1651, 1989 | 235 | 1989 |
Engineering a 2D protein–DNA crystal J Malo, JC Mitchell, C Vénien‐Bryan, JR Harris, H Wille, DJ Sherratt, ... Angewandte Chemie International Edition 44 (20), 3057-3061, 2005 | 212 | 2005 |
THE CHICKEN NEURAL EXTRACELLULAR-MATRIX MOLECULE RESTRICTIN-SIMILARITY WITH EGF-LIKE, FIBRONECTIN TYPE-III-LIKE, AND FIBRINOGEN-LIKE MOTIFS U NORENBERG, H WILLE, JM WOLFF, R FRANK, FG RATHJEN NEURON 8 (5), 849-863, 1992 | 191* | 1992 |
The structural architecture of an infectious mammalian prion using electron cryomicroscopy E Vázquez-Fernández, MR Vos, P Afanasyev, L Cebey, AM Sevillano, ... PLoS pathogens 12 (9), e1005835, 2016 | 178 | 2016 |
Mechanisms of prion protein assembly into amyloid J Stöhr, N Weinmann, H Wille, T Kaimann, L Nagel-Steger, E Birkmann, ... Proceedings of the National Academy of Sciences 105 (7), 2409-2414, 2008 | 174 | 2008 |
A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic mice K Kaneko, HL Ball, H Wille, H Zhang, D Groth, M Torchia, P Tremblay, ... Journal of molecular biology 295 (4), 997-1007, 2000 | 164 | 2000 |
Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform K Kaneko, D Peretz, KM Pan, TC Blochberger, H Wille, R Gabizon, ... Proceedings of the National Academy of Sciences 92 (24), 11160-11164, 1995 | 151 | 1995 |