| Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria G Gasiunas, R Barrangou, P Horvath, V Siksnys Proceedings of the National Academy of Sciences 109 (39), E2579-E2586, 2012 | 3861 | 2012 |
| The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli R Sapranauskas, G Gasiunas, C Fremaux, R Barrangou, P Horvath, ... Nucleic acids research 39 (21), 9275-9282, 2011 | 1516 | 2011 |
| Cas3 is a single‐stranded DNA nuclease and ATP‐dependent helicase in the CRISPR/Cas immune system T Sinkunas, G Gasiunas, C Fremaux, R Barrangou, P Horvath, V Siksnys The EMBO journal 30 (7), 1335-1342, 2011 | 603 | 2011 |
| Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes MD Szczelkun, MS Tikhomirova, T Sinkunas, G Gasiunas, T Karvelis, ... Proceedings of the National Academy of Sciences 111 (27), 9798-9803, 2014 | 523 | 2014 |
| crRNA and tracrRNA guide Cas9-mediated DNA interference in Streptococcus thermophilus T Karvelis, G Gasiunas, A Miksys, R Barrangou, P Horvath, V Siksnys RNA biology 10 (5), 841-851, 2013 | 368 | 2013 |
| In vitro reconstitution of Cascade‐mediated CRISPR immunity in Streptococcus thermophilus T Sinkunas, G Gasiunas, SP Waghmare, MJ Dickman, R Barrangou, ... The EMBO journal 32 (3), 385-394, 2013 | 324 | 2013 |
| Streptococcus thermophilus CRISPR-Cas9 systems enable specific editing of the human genome M Müller, CM Lee, G Gasiunas, TH Davis, TJ Cradick, V Siksnys, G Bao, ... Molecular Therapy 24 (3), 636-644, 2016 | 299 | 2016 |
| RNA-directed DNA cleavage by the Cas9-crRNA complex G Gasiunas, T Karvelis US Patent 9,637,739, 2017 | 283 | 2017 |
| RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX V Siksnys, G Gasiunas, T Karvelis, A Lubys, L Zaliauskiene, M Glemzaite, ... US Patent App. 14/385,857, 2015 | 277 | 2015 |
| Rapid characterization of CRISPR-Cas9 protospacer adjacent motif sequence elements T Karvelis, G Gasiunas, J Young, G Bigelyte, A Silanskas, M Cigan, ... Genome biology 16, 1-13, 2015 | 248 | 2015 |
| Molecular mechanisms of CRISPR-mediated microbial immunity G Gasiunas, T Sinkunas, V Siksnys Cellular and molecular life sciences 71, 449-465, 2014 | 162 | 2014 |
| A catalogue of biochemically diverse CRISPR-Cas9 orthologs G Gasiunas, JK Young, T Karvelis, D Kazlauskas, T Urbaitis, ... Nature communications 11 (1), 5512, 2020 | 145 | 2020 |
| RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX V Siksnys, G Gasiunas, T Karvelis US Patent App. 14/743,764, 2015 | 119 | 2015 |
| RNA-dependent DNA endonuclease Cas9 of the CRISPR system: Holy Grail of genome editing? G Gasiunas, V Siksnys Trends in Microbiology 21 (11), 562-567, 2013 | 117 | 2013 |
| Lactase nonpersistence is directed by DNA-variation-dependent epigenetic aging V Labrie, OJ Buske, E Oh, R Jeremian, C Ptak, G Gasiūnas, A Maleckas, ... Nature structural & molecular biology 23 (6), 566-573, 2016 | 106 | 2016 |
| Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor S Balderston, JJ Taulbee, E Celaya, K Fung, A Jiao, K Smith, R Hajian, ... Nature Biomedical Engineering 5 (7), 713-725, 2021 | 101 | 2021 |
| RNA-directed DNA cleavage by the Cas9-crRNA complex G Gasiunas, T Karvelis, A Lubys, L Zaliauskiene, M Gasiuniene, A Smith US Patent 11,555,187, 2023 | 71 | 2023 |
| Structure of the DNA-bound spacer capture complex of a type II CRISPR-Cas system M Wilkinson, G Drabavicius, A Silanskas, G Gasiunas, V Siksnys, ... Molecular cell 75 (1), 90-101. e5, 2019 | 64 | 2019 |
| RNA-directed DNA cleavage by the Cas9-crRNA complex G Gasiūnas, T Karvelis US Patent 10,844,378, 2020 | 59 | 2020 |
| Programmable DNA cleavage in vitro by Cas9 T Karvelis, G Gasiunas, V Siksnys Biochemical Society Transactions 41 (6), 1401-1406, 2013 | 48 | 2013 |
