Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer U Sahin, E Derhovanessian, M Miller, BP Kloke, P Simon, M Löwer, ... Nature 547 (7662), 222-226, 2017 | 2239 | 2017 |
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy LM Kranz, M Diken, H Haas, S Kreiter, C Loquai, KC Reuter, M Meng, ... Nature 534 (7607), 396-401, 2016 | 1560 | 2016 |
Mutant MHC class II epitopes drive therapeutic immune responses to cancer S Kreiter, M Vormehr, N Van de Roemer, M Diken, M Löwer, J Diekmann, ... Nature 520 (7549), 692-696, 2015 | 1309 | 2015 |
Cancer classification using the Immunoscore: a worldwide task force J Galon, F Pagès, FM Marincola, HK Angell, M Thurin, A Lugli, I Zlobec, ... Journal of translational medicine 10, 1-10, 2012 | 958 | 2012 |
Exploiting the mutanome for tumor vaccination JC Castle, S Kreiter, J Diekmann, M Löwer, N Van de Roemer, J de Graaf, ... Cancer research 72 (5), 1081-1091, 2012 | 945 | 2012 |
Actively personalized vaccination trial for newly diagnosed glioblastoma N Hilf, S Kuttruff-Coqui, K Frenzel, V Bukur, S Stevanović, ... Nature 565 (7738), 240-245, 2019 | 769 | 2019 |
Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells S Holtkamp, S Kreiter, A Selmi, P Simon, M Koslowski, C Huber, ... Blood 108 (13), 4009-4017, 2006 | 704 | 2006 |
An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma U Sahin, P Oehm, E Derhovanessian, RA Jabulowsky, M Vormehr, ... Nature 585 (7823), 107-112, 2020 | 669 | 2020 |
Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity S Kreiter, A Selmi, M Diken, M Koslowski, CM Britten, C Huber, Ö Türeci, ... Cancer research 70 (22), 9031-9040, 2010 | 403 | 2010 |
Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma JC Castle, M Loewer, S Boegel, J de Graaf, C Bender, AD Tadmor, ... BMC genomics 15, 1-12, 2014 | 385 | 2014 |
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis C Krienke, L Kolb, E Diken, M Streuber, S Kirchhoff, T Bukur, ... Science 371 (6525), 145-153, 2021 | 325 | 2021 |
Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo AN Kuhn, M Diken, S Kreiter, A Selmi, J Kowalska, J Jemielity, ... Gene therapy 17 (8), 961-971, 2010 | 261 | 2010 |
Tumor vaccination using messenger RNA: prospects of a future therapy S Kreiter, M Diken, A Selmi, Ö Türeci, U Sahin Current opinion in immunology 23 (3), 399-406, 2011 | 231 | 2011 |
Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation M Diken, S Kreiter, A Selmi, CM Britten, C Huber, Ö Türeci, U Sahin Gene therapy 18 (7), 702-708, 2011 | 205 | 2011 |
Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals S Kreiter, A Selmi, M Diken, M Sebastian, P Osterloh, H Schild, C Huber, ... The Journal of Immunology 180 (1), 309-318, 2008 | 191 | 2008 |
Individualized vaccines for cancer U Sahin, S Kreiter, M Diken, J Diekmann, M Koslowski, C Britten, ... US Patent 10,738,355, 2020 | 178 | 2020 |
Targeting the heterogeneity of cancer with individualized neoepitope vaccines Ö Türeci, M Vormehr, M Diken, S Kreiter, C Huber, U Sahin Clinical Cancer Research 22 (8), 1885-1896, 2016 | 159 | 2016 |
Modification of RNA, producing an increased transcript stability and translation efficiency U Sahin, S Holtkamp, Ö Türeci, S Kreiter US Patent 9,476,055, 2016 | 112 | 2016 |
Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models C Hotz, TR Wagenaar, F Gieseke, DS Bangari, M Callahan, H Cao, ... Science translational medicine 13 (610), eabc7804, 2021 | 107 | 2021 |
FLT3 ligand enhances the cancer therapeutic potency of naked RNA vaccines S Kreiter, M Diken, A Selmi, J Diekmann, S Attig, Y Hüsemann, ... Cancer research 71 (19), 6132-6142, 2011 | 88 | 2011 |