Novel trimodal MALDI imaging mass spectrometry (IMS3) at 10 μm reveals spatial lipid and peptide correlates implicated in Aβ plaque pathology in Alzheimer’s disease I Kaya, D Brinet, W Michno, M Başkurt, H Zetterberg, K Blenow, ... ACS chemical neuroscience 8 (12), 2778-2790, 2017 | 107 | 2017 |
Chemical analysis of single cells PE Oomen, MA Aref, I Kaya, NTN Phan, AG Ewing Analytical chemistry 91 (1), 588-621, 2018 | 86 | 2018 |
Delineating amyloid plaque associated neuronal sphingolipids in transgenic Alzheimer’s disease mice (tgArcSwe) using MALDI imaging mass spectrometry I Kaya, D Brinet, W Michno, S Syvänen, D Sehlin, H Zetterberg, ... ACS chemical neuroscience 8 (2), 347-355, 2017 | 80 | 2017 |
Histology-compatible MALDI mass spectrometry based imaging of neuronal lipids for subsequent immunofluorescent staining I Kaya, W Michno, D Brinet, Y Iacone, G Zanni, K Blennow, H Zetterberg, ... Analytical chemistry 89 (8), 4685-4694, 2017 | 76 | 2017 |
Shedding light on the molecular pathology of amyloid plaques in transgenic Alzheimer’s disease mice using multimodal MALDI imaging mass spectrometry I Kaya, H Zetterberg, K Blennow, J Hanrieder ACS chemical neuroscience 9 (7), 1802-1817, 2018 | 73 | 2018 |
Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer’s disease pathology W Michno, S Nyström, P Wehrli, T Lashley, G Brinkmalm, L Guerard, ... Journal of Biological Chemistry 294 (17), 6719-6732, 2019 | 71 | 2019 |
Brain region‐specific amyloid plaque‐associated myelin lipid loss, APOE deposition and disruption of the myelin sheath in familial Alzheimer’s disease mice I Kaya, E Jennische, S Lange, A Tarik Baykal, P Malmberg, JS Fletcher Journal of neurochemistry 154 (1), 84-98, 2020 | 64 | 2020 |
On-Tissue Chemical Derivatization of Catecholamines Using 4-(N-Methyl)pyridinium Boronic Acid for ToF-SIMS and LDI-ToF Mass Spectrometry Imaging I Kaya, SM Brülls, J Dunevall, E Jennische, S Lange, J Martensson, ... Analytical chemistry 90 (22), 13580-13590, 2018 | 61 | 2018 |
Probing amyloid‐β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry L Carlred, W Michno, I Kaya, P Sjövall, S Syvänen, J Hanrieder Journal of neurochemistry 138 (3), 469-478, 2016 | 51 | 2016 |
Spatial lipidomics reveals region and long chain base specific accumulations of monosialogangliosides in amyloid plaques in familial Alzheimer’s disease mice (5xFAD) brain I Kaya, E Jennische, J Dunevall, S Lange, AG Ewing, P Malmberg, ... ACS chemical neuroscience 11 (1), 14-24, 2019 | 48 | 2019 |
Multimodal chemical imaging of amyloid plaque polymorphism reveals Aβ aggregation dependent anionic lipid accumulations and metabolism W Michno, I Kaya, S Nyström, L Guerard, KPR Nilsson, ... Analytical chemistry 90 (13), 8130-8138, 2018 | 45 | 2018 |
Multimodal MALDI imaging mass spectrometry reveals spatially correlated lipid and protein changes in mouse heart with acute myocardial infarction I Kaya, S Samfors, M Levin, J Borén, JS Fletcher Journal of the American Society for Mass Spectrometry 31 (10), 2133-2142, 2020 | 34 | 2020 |
Dual polarity MALDI imaging mass spectrometry on the same pixel points reveals spatial lipid localizations at high-spatial resolutions in rat small intestine I Kaya, E Jennische, S Lange, P Malmberg Analytical Methods 10 (21), 2428-2435, 2018 | 25 | 2018 |
Multimodal chemical imaging of a single brain tissue section using ToF-SIMS, MALDI-ToF and immuno/histochemical staining I Kaya, E Jennische, S Lange, P Malmberg Analyst 146 (4), 1169-1177, 2021 | 24 | 2021 |
(CO2)n+, (H2O)n+, and (H2O)n+ (CO2) gas cluster ion beam secondary ion mass spectrometry: analysis of lipid extracts, cells, and Alzheimer’s model … K Dimovska Nilsson, A Karagianni, I Kaya, M Henricsson, JS Fletcher Analytical and Bioanalytical Chemistry 413 (16), 4181-4194, 2021 | 13 | 2021 |
Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson’s disease primate model I Kaya, A Nilsson, D Luptáková, Y He, T Vallianatou, P Bjärterot, ... npj Parkinson's Disease 9 (1), 118, 2023 | 11 | 2023 |
Advances in spatial mass spectrometry enable in-depth neuropharmacodynamics S Baijnath, I Kaya, A Nilsson, R Shariatgorji, PE Andrén Trends in Pharmacological Sciences 43 (9), 740-753, 2022 | 11 | 2022 |
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents Y He, I Kaya, R Shariatgorji, J Lundkvist, LU Wahlberg, A Nilsson, ... Nature Communications 14 (1), 5804, 2023 | 9 | 2023 |
On-tissue chemical derivatization for comprehensive mapping of brain carboxyl and aldehyde metabolites by MALDI–MS imaging I Kaya, LS Schembri, A Nilsson, R Shariatgorji, S Baijnath, X Zhang, ... Journal of the American Society for Mass Spectrometry 34 (5), 836-846, 2023 | 9 | 2023 |
Antisecretory factor (AF) egg-yolk peptides reflects the intake of AF-activating feed in hens I Kaya, E Johansson, S Lange, P Malmberg Clinical Nutrition Experimental 12, 27-36, 2017 | 5 | 2017 |