The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress JR Morris, C Boutell, M Keppler, R Densham, D Weekes, A Alamshah, ... Nature 462 (7275), 886-890, 2009 | 528 | 2009 |
Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection RM Densham, AJ Garvin, HR Stone, J Strachan, RA Baldock, ... Nature structural & molecular biology 23 (7), 647-655, 2016 | 284 | 2016 |
The proteasomal de‐ubiquitinating enzyme POH1 promotes the double‐strand DNA break response LR Butler, RM Densham, J Jia, AJ Garvin, HR Stone, V Shah, D Weekes, ... The EMBO journal 31 (19), 3918-3934, 2012 | 164 | 2012 |
ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest DE Todd, RM Densham, SA Molton, K Balmanno, C Newson, CR Weston, ... Oncogene 23 (19), 3284-3295, 2004 | 117 | 2004 |
The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair AJ Garvin, RM Densham, SA Blair‐Reid, KM Pratt, HR Stone, D Weekes, ... EMBO reports 14 (11), 975-983, 2013 | 110 | 2013 |
Isomerization of BRCA1–BARD1 promotes replication fork protection M Daza-Martin, K Starowicz, M Jamshad, S Tye, GE Ronson, HL MacKay, ... Nature 571 (7766), 521-527, 2019 | 108 | 2019 |
MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability RM Densham, E O'Neill, J Munro, I König, K Anderson, W Kolch, ... Molecular and cellular biology, 2009 | 97 | 2009 |
USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A M Uckelmann, RM Densham, R Baas, HHK Winterwerp, A Fish, TK Sixma, ... Nature communications 9 (1), 229, 2018 | 92 | 2018 |
The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair RM Densham, JR Morris Nucleus 8 (2), 116-125, 2017 | 54 | 2017 |
Stability of p21Waf1/Cip1 CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton ML Coleman, RM Densham, DR Croft, MF Olson Oncogene 25 (19), 2708-2716, 2006 | 52 | 2006 |
Moving mountains—the BRCA1 promotion of DNA resection RM Densham, JR Morris Frontiers in Molecular Biosciences 6, 79, 2019 | 48 | 2019 |
The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms AJ Garvin, AK Walker, RM Densham, AS Chauhan, HR Stone, HL Mackay, ... Genes & Development 33 (5-6), 333-347, 2019 | 39 | 2019 |
Discovery of peptide ligands targeting a specific ubiquitin-like domain–binding site in the deubiquitinase USP11 A Spiliotopoulos, LB Ferreras, RM Densham, SG Caulton, BC Maddison, ... Journal of Biological Chemistry 294 (2), 424-436, 2019 | 35 | 2019 |
ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover RM Densham, DE Todd, K Balmanno, SJ Cook Cellular Signalling 20 (11), 1986-1994, 2008 | 26 | 2008 |
Imaging nanoscale nuclear structures with expansion microscopy EL Faulkner, JA Pike, RM Densham, E Garlick, SG Thomas, RK Neely, ... Journal of Cell Science 135 (14), jcs259009, 2022 | 8 | 2022 |
BRCA1-BARD1: The importance of being in shape M Daza-Martin, RM Densham, JR Morris Molecular & Cellular Oncology 6 (6), e1656500, 2019 | 6 | 2019 |
New regulators of the BRCA1 response to genotoxic stress JR Morris, C Boutell, M Keppler, R Densham, D Weekes, A Alamshah, ... Breast Cancer Research 12, 1-1, 2010 | 2 | 2010 |
Disruption of pml nuclear bodies cooperates in the pathogenesis of acute promyelocytic leukemia E Moravcsik, M Joannides, E Voisset, EW Stratford, BB Zeisig, J Morris, ... Blood 122 (21), 3721, 2013 | 1 | 2013 |
USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication. HL Mackay, HR Stone, K Ellis, G Ronson, K Starowicz, AJ Garvin, ... bioRxiv, 2024.01. 10.574674, 2024 | | 2024 |
SUMO4 regulates DNA double-strand break repair independently of conjugation AJ Garvin, AJ Lanz, RM Densham, JR Morris bioRxiv, 2022.03. 23.485504, 2022 | | 2022 |