| Evolutionary biochemistry: revealing the historical and physical causes of protein properties MJ Harms, JW Thornton Nature Reviews Genetics 14 (8), 559-571, 2013 | 365 | 2013 |
| Analyzing protein structure and function using ancestral gene reconstruction MJ Harms, JW Thornton Current opinion in structural biology 20 (3), 360-366, 2010 | 262 | 2010 |
| Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor JT Bridgham, GN Eick, C Larroux, K Deshpande, MJ Harms, ... PLoS biology 8 (10), e1000497, 2010 | 259 | 2010 |
| Arginine residues at internal positions in a protein are always charged MJ Harms, JL Schlessman, GR Sue, B García-Moreno E Proceedings of the National Academy of Sciences 108 (47), 18954-18959, 2011 | 192 | 2011 |
| Historical contingency and its biophysical basis in glucocorticoid receptor evolution MJ Harms, JW Thornton Nature 512 (7513), 203-207, 2014 | 171 | 2014 |
| How sequence defines structure: a crystallographic map of DNA structure and conformation FA Hays, A Teegarden, ZJR Jones, M Harms, D Raup, J Watson, ... Proceedings of the National Academy of Sciences 102 (20), 7157-7162, 2005 | 168 | 2005 |
| The pKa values of acidic and basic residues buried at the same internal location in a protein are governed by different factors MJ Harms, CA Castañeda, JL Schlessman, GR Sue, DG Isom, ... Journal of molecular biology 389 (1), 34-47, 2009 | 162 | 2009 |
| The thermostability and specificity of ancient proteins LC Wheeler, SA Lim, S Marqusee, MJ Harms Current opinion in structural biology 38, 37-43, 2016 | 142 | 2016 |
| Evolution of minimal specificity and promiscuity in steroid hormone receptors GN Eick, JK Colucci, MJ Harms, EA Ortlund, JW Thornton PLoS genetics 8 (11), e1003072, 2012 | 141 | 2012 |
| Detecting high-order epistasis in nonlinear genotype-phenotype maps ZR Sailer, MJ Harms Genetics 205 (3), 1079-1088, 2017 | 138 | 2017 |
| High-order epistasis shapes evolutionary trajectories ZR Sailer, MJ Harms PLoS computational biology 13 (5), e1005541, 2017 | 113 | 2017 |
| Robustness of reconstructed ancestral protein functions to statistical uncertainty GN Eick, JT Bridgham, DP Anderson, MJ Harms, JW Thornton Molecular biology and evolution 34 (2), 247-261, 2016 | 109 | 2016 |
| A buried lysine that titrates with a normal pKa: Role of conformational flexibility at the protein–water interface as a determinant of pKavalues MJ Harms, JL Schlessman, MS Chimenti, GR Sue, A Damjanović, ... Protein Science 17 (5), 833-845, 2008 | 100 | 2008 |
| Thermodynamic system drift in protein evolution KM Hart, MJ Harms, BH Schmidt, C Elya, JW Thornton, S Marqusee PLoS biology 12 (11), e1001994, 2014 | 99 | 2014 |
| Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors MJ Harms, GN Eick, D Goswami, JK Colucci, PR Griffin, EA Ortlund, ... Proceedings of the National Academy of Sciences 110 (28), 11475-11480, 2013 | 80 | 2013 |
| Molecular ensembles make evolution unpredictable ZR Sailer, MJ Harms Proceedings of the National Academy of Sciences 114 (45), 11938-11943, 2017 | 76 | 2017 |
| Laser light‐scattering evidence for an altered association of βB1‐crystallin deamidated in the connecting peptide MJ Harms, PA Wilmarth, DM Kapfer, EA Steel, LL David, HP Bächinger, ... Protein science 13 (3), 678-686, 2004 | 50 | 2004 |
| Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family LC Wheeler, MT Donor, JS Prell, MJ Harms PloS one 11 (10), e0164740, 2016 | 43 | 2016 |
| Evolutionary trend toward kinetic stability in the folding trajectory of RNases H SA Lim, KM Hart, MJ Harms, S Marqusee Proceedings of the National Academy of Sciences 113 (46), 13045-13050, 2016 | 42 | 2016 |
| pytc: Open-Source Python Software for Global Analyses of Isothermal Titration Calorimetry Data H Duvvuri, LC Wheeler, MJ Harms Biochemistry 57 (18), 2578-2583, 2018 | 27 | 2018 |
Joseph W. ThorntonUniversity of Chicago, Depts. of Human Genetics and Ecology & Evolution在 uchicago.edu 的电子邮件经过验证
