| Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models HJ Kim, AR Raphael, ES LaDow, L McGurk, RA Weber, JQ Trojanowski, ... Nature genetics 46 (2), 152-160, 2014 | 409 | 2014 |
| Drosophila as an In Vivo Model for Human Neurodegenerative Disease L McGurk, A Berson, NM Bonini Genetics 201 (2), 377-402, 2015 | 359 | 2015 |
| Poly (ADP-ribose) prevents pathological phase separation of TDP-43 by promoting liquid Demixing and stress granule localization L McGurk, E Gomes, L Guo, J Mojsilovic-Petrovic, V Tran, RG Kalb, ... Molecular cell 71 (5), 703-717. e9, 2018 | 358 | 2018 |
| Editing independent effects of ADARs on the miRNA/siRNA pathways BSE Heale, LP Keegan, L McGurk, G Michlewski, J Brindle, CM Stanton, ... The EMBO journal 28 (20), 3145-3156, 2009 | 215 | 2009 |
| Nuclear poly (ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis L McGurk, J Mojsilovic-Petrovic, VM Van Deerlin, J Shorter, RG Kalb, ... Acta neuropathologica communications 6 (1), 1-15, 2018 | 94 | 2018 |
| Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects LP Keegan, L McGurk, JP Palavicini, J Brindle, S Paro, X Li, ... Nucleic Acids Research 39 (16), 7249-7262, 2011 | 80 | 2011 |
| Three-dimensional imaging of Drosophila melanogaster L McGurk, H Morrison, LP Keegan, J Sharpe, MA O'Connell PLoS One 2 (9), e834, 2007 | 77 | 2007 |
| Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System Y Hayashi, LK Ford, L Fioriti, L McGurk, M Zhang Journal of Neuroscience 41 (5), 834-844, 2021 | 56 | 2021 |
| Adar RNA editing-dependent and-independent effects are required for brain and innate immune functions in Drosophila P Deng, A Khan, D Jacobson, N Sambrani, L McGurk, X Li, A Jayasree, ... Nature Communications 11 (1), 1-13, 2020 | 56 | 2020 |
| Poly-A Binding Protein-1 Localization to a Subset of TDP-43 Inclusions in Amyotrophic Lateral Sclerosis Occurs More Frequently in Patients Harboring an Expansion in C9orf72 L McGurk, VM Lee, JQ Trojanowksi, VM Van Deerlin, EB Lee, NM Bonini Journal of Neuropathology & Experimental Neurology 73 (9), 837-845, 2014 | 52 | 2014 |
| Poly (ADP-ribose) engages the TDP-43 nuclear-localization sequence to regulate granulo-filamentous aggregation L McGurk, E Gomes, L Guo, J Shorter, NM Bonini Biochemistry 57 (51), 6923-6926, 2018 | 32 | 2018 |
| Poly (ADP-Ribosylation) in Age-Related Neurological Disease L McGurk, OM Rifai, NM Bonini Trends in Genetics 35 (8), 601-613, 2019 | 29 | 2019 |
| Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila L McGurk, NM Bonini Human molecular genetics 21 (1), 76-84, 2012 | 27 | 2012 |
| Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy A Khan, S Paro, L McGurk, N Sambrani, MC Hogg, J Brindle, G Pennetta, ... BMC Biology 18 (1), 1-16, 2020 | 24 | 2020 |
| TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and-2 L McGurk, OM Rifai, NM Bonini Journal of cell science 133 (12), jcs245811, 2020 | 18 | 2020 |
| Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology L François-Moutal, DD Scott, AJ Ambrose, CJ Zerio, ... Scientific Reports 12 (1), 1-14, 2022 | 16 | 2022 |
| Yeast Informs Alzheimer's Disease L McGurk, NM Bonini Science 334 (6060), 1212-1213, 2011 | 9 | 2011 |
| Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence L McGurk, OM Rifai, O Shcherbakova, AE Perlegos, CN Byrns, ... Human Molecular Genetics 30 (19), 1797-1810, 2021 | 8 | 2021 |
| The temporal and spatial expression pattern of myosin Va, Vb and VI in the mouse ovary L McGurk, G Tzolovsky, N Spears, M Bownes Gene expression patterns 6 (8), 900-907, 2006 | 8 | 2006 |
| Ecdysteroid action in insect reproduction AS Raikhel, L McGurk, M Bownes Academic Press, 2003 | 6 | 2003 |
Nancy M BoniniUniversity of Pennsylvania在 sas.upenn.edu 的电子邮件经过验证
