Detecting chromatin interactions between and along sister chromatids with SisterC ME Oomen, AK Hedger, JK Watts, J Dekker Nature Methods 17 (10), 1002-1009, 2020 | 44 | 2020 |
Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors AN Matthew, J Zephyr, DN Rao, M Henes, W Kamran, K Kosovrasti, ... mBio 11 (2), 2020 | 16* | 2020 |
Discovery of Quinoxaline-Based P1–P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants D Nageswara Rao, J Zephyr, M Henes, ET Chan, AN Matthew, ... Journal of Medicinal Chemistry 64 (16), 11972-11989, 2021 | 11 | 2021 |
Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state A Maiti, AK Hedger, W Myint, V Balachandran, JK Watts, CA Schiffer, ... Nature Communications 13 (1), 7117, 2022 | 7 | 2022 |
Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance J Zephyr, DN Rao, SV Vo, M Henes, K Kosovrasti, AN Matthew, ... Journal of Molecular Biology 434 (9), 167503, 2022 | 6 | 2022 |
In Vivo Prime Editing by Lipid Nanoparticle Co-Delivery of Chemically Modified pegRNA and Prime Editor mRNA Z Chen, K Kelly, H Cheng, X Dong, AK Hedger, L Li, EJ Sontheimer, ... GEN Biotechnology 2 (6), 490-502, 2023 | 4 | 2023 |
Progress toward an amplifiable metabolic label for DNA: conversion of 4-thiothymidine (4sT) to 5-methyl-2′-deoxycytidine and synthesis of a 4sT phosphorodiamidate prodrug AK Hedger, ME Oomen, V Liu, MP Moazami, N Rhind, J Dekker, JK Watts Canadian Journal of Chemistry 96 (7), 636-645, 2018 | 3 | 2018 |
Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors SR Hildebrand, AK Hedger, K Yamada, JK Watts, A Khvorova RNA 29 (7), 1077-1083, 2023 | 1 | 2023 |
Double Click: Unexpected 1: 2 Stoichiometry in a Norbornene–Tetrazine Reaction G Devi, AK Hedger, RJ Whitby, JK Watts The Journal of Organic Chemistry 88 (9), 5341-5347, 2023 | 1 | 2023 |