Targeting fatty acid and carbohydrate oxidation—a novel therapeutic intervention in the ischemic and failing heart JS Jaswal, W Keung, W Wang, JR Ussher, GD Lopaschuk Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1813 (7), 1333-1350, 2011 | 478 | 2011 |
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption JR Ussher, TR Koves, VJJ Cadete, L Zhang, JS Jaswal, SJ Swyrd, ... Diabetes 59 (10), 2453-2464, 2010 | 409 | 2010 |
Role of fatty acid uptake and fatty acid β-oxidation in mediating insulin resistance in heart and skeletal muscle L Zhang, W Keung, V Samokhvalov, W Wang, GD Lopaschuk Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2010 | 360 | 2010 |
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake S Gao, KP Kinzig, S Aja, KA Scott, W Keung, S Kelly, K Strynadka, ... Proceedings of the National Academy of Sciences 104 (44), 17358-17363, 2007 | 263 | 2007 |
Mouse models of atherosclerosis: a historical perspective and recent advances YT Lee, HY Lin, YWF Chan, KHC Li, OTL To, BP Yan, T Liu, G Li, ... Lipids in health and disease 16, 1-11, 2017 | 219 | 2017 |
Aptamer-based microfluidic electrochemical biosensor for monitoring cell-secreted trace cardiac biomarkers SR Shin, YS Zhang, DJ Kim, A Manbohi, H Avci, A Silvestri, J Aleman, ... Analytical chemistry 88 (20), 10019-10027, 2016 | 217 | 2016 |
Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury JR Ussher, W Wang, M Gandhi, W Keung, V Samokhvalov, T Oka, ... Cardiovascular research 94 (2), 359-369, 2012 | 196 | 2012 |
Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells RA Li, W Keung, TJ Cashman, PC Backeris, BV Johnson, ES Bardot, ... Biomaterials 163, 116-127, 2018 | 157 | 2018 |
Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice W Keung, JR Ussher, JS Jaswal, M Raubenheimer, VHM Lam, CS Wagg, ... Diabetes 62 (3), 711-720, 2013 | 147 | 2013 |
A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells Z Weng, CW Kong, L Ren, I Karakikes, L Geng, J He, MZY Chow, CF Mok, ... Stem cells and development 23 (14), 1704-1716, 2014 | 123 | 2014 |
Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes W Keung, KR Boheler, RA Li Stem cell research & therapy 5, 1-11, 2014 | 110 | 2014 |
A heart‐breast cancer‐on‐a‐chip platform for disease modeling and monitoring of cardiotoxicity induced by cancer chemotherapy J Lee, S Mehrotra, E Zare‐Eelanjegh, RO Rodrigues, A Akbarinejad, ... Small 17 (15), 2004258, 2021 | 98 | 2021 |
Electrophysiological mechanisms of long and short QT syndromes G Tse, YWF Chan, W Keung, BP Yan IJC Heart & Vasculature 14, 8-13, 2017 | 94 | 2017 |
Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias J Wang, A Chen, DK Lieu, I Karakikes, G Chen, W Keung, CW Chan, ... Biomaterials 34 (35), 8878-8886, 2013 | 84 | 2013 |
Machine learning of human pluripotent stem cell-derived engineered cardiac tissue contractility for automated drug classification EK Lee, DD Tran, W Keung, P Chan, G Wong, CW Chan, KD Costa, RA Li, ... Stem Cell Reports 9 (5), 1560-1572, 2017 | 65 | 2017 |
Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance JR Ussher, CDL Folmes, W Keung, N Fillmore, JS Jaswal, VJ Cadete, ... PLoS One 7 (5), e37703, 2012 | 62 | 2012 |
Human ISL1+ ventricular progenitors self-assemble into an in vivo functional heart patch and preserve cardiac function post infarction KS Foo, ML Lehtinen, CY Leung, X Lian, J Xu, W Keung, L Geng, ... Molecular Therapy 26 (7), 1644-1659, 2018 | 61 | 2018 |
Electrophysiological mechanisms of Brugada syndrome: insights from pre-clinical and clinical studies G Tse, T Liu, KHC Li, V Laxton, YWF Chan, W Keung, RA Li, BP Yan Frontiers in physiology 7, 467, 2016 | 61 | 2016 |
Nonmulberry silk based ink for fabricating mechanically robust cardiac patches and endothelialized myocardium‐on‐a‐chip application S Mehrotra, BAG de Melo, M Hirano, W Keung, RA Li, BB Mandal, ... Advanced functional materials 30 (12), 1907436, 2020 | 60 | 2020 |
Proteomic analysis of human pluripotent stem Cell–Derived, fetal, and adult ventricular cardiomyocytes reveals pathways crucial for cardiac metabolism and maturation E Poon, W Keung, Y Liang, R Ramalingam, B Yan, S Zhang, A Chopra, ... Circulation: Cardiovascular Genetics 8 (3), 427-436, 2015 | 60 | 2015 |