Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases W Xu, H Yang, Y Liu, Y Yang, P Wang, SH Kim, S Ito, C Yang, P Wang, ... Cancer cell 19 (1), 17-30, 2011 | 3064 | 2011 |
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors M Xiao, H Yang, W Xu, S Ma, H Lin, H Zhu, L Liu, Y Liu, C Yang, Y Xu, ... Genes & development 26 (12), 1326-1338, 2012 | 1116 | 2012 |
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway X Gui, H Yang, T Li, X Tan, P Shi, M Li, F Du, ZJ Chen Nature, 262–266, 2019 | 851 | 2019 |
cGAS is essential for cellular senescence H Yang, H Wang, J Ren, Q Chen, ZJ Chen Proceedings of the National Academy of Sciences 114 (23), E4612-E4620, 2017 | 851 | 2017 |
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation H Yang, Y Liu, F Bai, JY Zhang, SH Ma, J Liu, ZD Xu, HG Zhu, ZQ Ling, ... Oncogene 32 (5), 663-669, 2013 | 649 | 2013 |
IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives H Yang, D Ye, KL Guan, Y Xiong Clinical cancer research 18 (20), 5562-5571, 2012 | 493 | 2012 |
WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation Y Wang, M Xiao, X Chen, L Chen, Y Xu, L Lv, P Wang, H Yang, S Ma, ... Molecular cell 57 (4), 662-673, 2015 | 309 | 2015 |
SIRT 3‐dependent GOT 2 acetylation status affects the malate–aspartate NADH shuttle activity and pancreatic tumor growth H Yang, L Zhou, Q Shi, Y Zhao, H Lin, M Zhang, S Zhao, Y Yang, ZQ Ling, ... The EMBO journal 34 (8), 1110-1125, 2015 | 190 | 2015 |
cGAS suppresses genomic instability as a decelerator of replication forks H Chen, H Chen, J Zhang, Y Wang, A Simoneau, H Yang, AS Levine, ... Science advances 6 (42), eabb8941, 2020 | 88 | 2020 |
D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth S Ma, B Jiang, W Deng, ZK Gu, FZ Wu, T Li, Y Xia, H Yang, D Ye, Y Xiong, ... Oncotarget 6 (11), 8606-8620, 2015 | 66 | 2015 |
TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites H Yang, H Lin, H Xu, L Zhang, L Cheng, B Wen, J Shou, K Guan, Y Xiong, ... Cell research 24 (8), 1017-1020, 2014 | 64 | 2014 |
Emerging roles of spliceosome in cancer and immunity H Yang, B Beutler, D Zhang Protein & cell 13 (8), 559-579, 2022 | 58 | 2022 |
Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics Q Liu, F Zhu, X Liu, Y Lu, K Yao, N Tian, L Tong, DA Figge, X Wang, ... Nature Metabolism 4 (5), 559-574, 2022 | 34 | 2022 |
Metabolic regulation on the immune environment of glioma through gut microbiota Y Lyu, H Yang, L Chen Seminars in cancer biology 86, 990-997, 2022 | 27 | 2022 |
Trafficking of NMDA receptors is essential for hippocampal synaptic plasticity and memory consolidation X Yang, R Gong, L Qin, Y Bao, Y Fu, S Gao, H Yang, J Ni, TF Yuan, W Lu Cell Reports 40 (7), 2022 | 24 | 2022 |
SARS-CoV-2 infection and the antiviral innate immune response H Yang, Y Lyu, F Hou Journal of Molecular Cell Biology 12 (12), 963-967, 2020 | 23 | 2020 |
The Zscan4-Tet2 transcription nexus regulates metabolic rewiring and enhances proteostasis to promote reprogramming ZL Cheng, ML Zhang, HP Lin, C Gao, JB Song, Z Zheng, L Li, Y Zhang, ... Cell Reports 32 (2), 2020 | 23 | 2020 |
Metabolic alteration in tumorigenesis H Yang, Y Xiong, KL Guan Science China Life Sciences 56, 1067-1075, 2013 | 17 | 2013 |
NEDD8-conjugating enzyme E2s: critical targets for cancer therapy L Zhou, X Lin, J Zhu, L Zhang, S Chen, H Yang, L Jia, B Chen Cell Death Discovery 9 (1), 23, 2023 | 11 | 2023 |
The inhibition of B7H3 by 2-HG accumulation is associated with downregulation of VEGFA in IDH mutated gliomas M Zhang, H Zhang, M Fu, J Zhang, C Zhang, Y Lv, F Fan, J Zhang, H Xu, ... Frontiers in Cell and Developmental Biology 9, 670145, 2021 | 8 | 2021 |