| Bioorganic synthesis of lipid-modified proteins for the study of signal transduction B Bader, K Kuhn, DJ Owen, H Waldmann, A Wittinghofer, J Kuhlmann Nature 403 (6766), 223-226, 2000 | 222 | 2000 |
| Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy LM Kaminskas, VM McLeod, GM Ryan, BD Kelly, JM Haynes, ... Journal of Controlled Release 183, 18-26, 2014 | 215 | 2014 |
| A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems LM Kaminskas, VM McLeod, BD Kelly, G Sberna, BJ Boyd, M Williamson, ... Nanomedicine: Nanotechnology, Biology and Medicine 8 (1), 103-111, 2012 | 205 | 2012 |
| Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker LM Kaminskas, BD Kelly, VM McLeod, G Sberna, DJ Owen, BJ Boyd, ... Journal of controlled release 152 (2), 241-248, 2011 | 154 | 2011 |
| Pulmonary administration of PEGylated polylysine dendrimers: absorption from the lung versus retention within the lung is highly size-dependent GM Ryan, LM Kaminskas, BD Kelly, DJ Owen, MP McIntosh, CJH Porter Molecular Pharmaceutics 10 (8), 2986-2995, 2013 | 133 | 2013 |
| Total synthesis of the potent anticancer Aglaia metabolites (−)-silvestrol and (−)-episilvestrol and the active analogue (−)-4′-desmethoxyepisilvestrol TE Adams, M El Sous, BC Hawkins, S Hirner, G Holloway, ML Khoo, ... Journal of the American Chemical Society 131 (4), 1607-1616, 2009 | 96 | 2009 |
| Synthesis of Functional Ras Lipoproteins and Fluorescent Derivatives K Kuhn, DJ Owen, B Bader, A Wittinghofer, J Kuhlmann, H Waldmann Journal of the American Chemical Society 123 (6), 1023-1035, 2001 | 94 | 2001 |
| PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin GM Ryan, LM Kaminskas, JB Bulitta, MP McIntosh, DJ Owen, CJH Porter Journal of Controlled Release 172 (1), 128-136, 2013 | 90 | 2013 |
| Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse … LM Kaminskas, VM McLeod, BD Kelly, C Cullinane, G Sberna, ... Molecular pharmaceutics 9 (3), 422-432, 2012 | 85 | 2012 |
| Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy CM Patterson, SB Balachander, I Grant, P Pop-Damkov, B Kelly, ... Communications Biology 4 (1), 112, 2021 | 83 | 2021 |
| Total Synthesis of (−)‐Episilvestrol and (−)‐Silvestrol M El Sous, ML Khoo, G Holloway, D Owen, PJ Scammells, MA Rizzacasa Angewandte Chemie 119 (41), 7981-7984, 2007 | 80 | 2007 |
| Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers LM Kaminskas, BD Kelly, VM McLeod, G Sberna, BJ Boyd, DJ Owen, ... Molecular pharmaceutics 8 (2), 338-349, 2011 | 75 | 2011 |
| Efficient Syntheses of Benzothiazepines as Antagonists for the Mitochondrial Sodium− Calcium Exchanger: Potential Therapeutics for Type II Diabetes Y Pei, MJ Lilly, DJ Owen, LJ D'Souza, XQ Tang, J Yu, R Nazarbaghi, ... The Journal of organic chemistry 68 (1), 92-103, 2003 | 65 | 2003 |
| Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous … LM Kaminskas, VM McLeod, DB Ascher, GM Ryan, S Jones, JM Haynes, ... Molecular pharmaceutics 12 (2), 432-443, 2015 | 63 | 2015 |
| Synthesis and evaluation of galactofuranosyl N, N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents DJ Owen, CB Davis, RD Hartnell, PD Madge, RJ Thomson, AKJ Chong, ... Bioorganic & medicinal chemistry letters 17 (8), 2274-2277, 2007 | 63 | 2007 |
| Chemo‐enzymatic synthesis of fluorescent Rab 7 proteins: Tools to study vesicular trafficking in cells DJ Owen, K Alexandrov, E Rostkova, AJ Scheidig, RS Goody, ... Angewandte Chemie International Edition 38 (4), 509-512, 1999 | 55 | 1999 |
| Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II NH Thomä, A Iakovenko, D Owen, AS Scheidig, H Waldmann, RS Goody, ... Biochemistry 39 (39), 12043-12052, 2000 | 54 | 2000 |
| Reducing dendrimer generation and PEG chain length increases drug release and promotes anticancer activity of PEGylated polylysine dendrimers conjugated with doxorubicin via a … D Mehta, N Leong, VM McLeod, BD Kelly, R Pathak, DJ Owen, ... Molecular Pharmaceutics 15 (10), 4568-4576, 2018 | 48 | 2018 |
| Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria CB Davis, RD Hartnell, PD Madge, DJ Owen, RJ Thomson, AKJ Chong, ... Carbohydrate research 342 (12-13), 1773-1780, 2007 | 48 | 2007 |
| Peptide conjugates as tools for the study of biological signal transduction F Eisele, DJ Owen, H Waldmann Bioorganic & medicinal chemistry 7 (2), 193-224, 1999 | 48 | 1999 |
