Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear R Marek, J Jin, TD Goode, TF Giustino, Q Wang, GM Acca, R Holehonnur, ... Nature neuroscience 21 (3), 384-392, 2018 | 223 | 2018 |
A hypothalamic circuit for the circadian control of aggression WD Todd, H Fenselau, JL Wang, R Zhang, NL Machado, A Venner, ... Nature neuroscience 21 (5), 717-724, 2018 | 145 | 2018 |
Ivermectin binding sites in human and invertebrate Cys-loop receptors T Lynagh, JW Lynch Trends in pharmacological sciences 33 (8), 432-441, 2012 | 110 | 2012 |
Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin T Lynagh, JW Lynch Frontiers in molecular neuroscience 5, 60, 2012 | 96 | 2012 |
A glycine residue essential for high ivermectin sensitivity in Cys-loop ion channel receptors T Lynagh, JW Lynch International journal for parasitology 40 (13), 1477-1481, 2010 | 89 | 2010 |
An improved ivermectin-activated chloride channel receptor for inhibiting electrical activity in defined neuronal populations T Lynagh, JW Lynch Journal of Biological Chemistry 285 (20), 14890-14897, 2010 | 89 | 2010 |
Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel T Lynagh, TI Webb, CL Dixon, BA Cromer, JW Lynch Journal of Biological Chemistry 286 (51), 43913-43924, 2011 | 68 | 2011 |
Principles of agonist recognition in Cys-loop receptors T Lynagh, SA Pless Frontiers in physiology 5, 160, 2014 | 59 | 2014 |
Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes T Lynagh, Y Mikhaleva, JM Colding, JC Glover, SA Pless Proceedings of the National Academy of Sciences 115 (33), 8430-8435, 2018 | 58 | 2018 |
A selectivity filter at the intracellular end of the acid-sensing ion channel pore T Lynagh, E Flood, C Boiteux, M Wulf, VV Komnatnyy, JM Colding, ... Elife 6, e24630, 2017 | 56 | 2017 |
Structure‐activity analysis of ginkgolide binding in the glycine receptor pore JA Heads, RL Hawthorne, T Lynagh, JW Lynch Journal of neurochemistry 105 (4), 1418-1427, 2008 | 44 | 2008 |
High throughput techniques for discovering new glycine receptor modulators and their binding sites DF Gilbert, R Islam, TP Lynagh, J Lynch, TI Webb Frontiers in Molecular Neuroscience 2, 873, 2009 | 43 | 2009 |
Mechanism and site of action of big dynorphin on ASIC1a CB Borg, N Braun, SA Heusser, Y Bay, D Weis, I Galleano, C Lund, ... Proceedings of the National Academy of Sciences 117 (13), 7447-7454, 2020 | 36 | 2020 |
Molecular basis for allosteric inhibition of acid-sensing ion channel 1a by ibuprofen T Lynagh, JL Romero-Rojo, C Lund, SA Pless Journal of Medicinal Chemistry 60 (19), 8192-8200, 2017 | 32 | 2017 |
Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics T Lynagh, BA Cromer, V Dufour, B Laube International Journal for Parasitology: Drugs and Drug Resistance 4 (3), 244-255, 2014 | 29 | 2014 |
Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels T Lynagh, RN Beech, MJ Lalande, K Keller, BA Cromer, AJ Wolstenholme, ... Scientific Reports 5 (1), 8558, 2015 | 26 | 2015 |
Opposing effects of the anesthetic propofol at pentameric ligand-gated ion channels mediated by a common site T Lynagh, B Laube Journal of Neuroscience 34 (6), 2155-2159, 2014 | 25 | 2014 |
Peptide inhibitors of the α-cobratoxin–nicotinic acetylcholine receptor interaction T Lynagh, S Kiontke, M Meyhoff-Madsen, BH Gless, J Johannesen, ... Journal of medicinal chemistry 63 (22), 13709-13718, 2020 | 20 | 2020 |
Determinants of ion selectivity in ASIC1a-and ASIC2a-containing acid-sensing ion channels T Lynagh, E Flood, C Boiteux, ZP Sheikh, TW Allen, SA Pless Journal of General Physiology 152 (2), 2020 | 14 | 2020 |
Comparative analysis defines a broader FMRFamide-gated sodium channel family and determinants of neuropeptide sensitivity M Dandamudi, H Hausen, T Lynagh Journal of Biological Chemistry 298 (7), 2022 | 12 | 2022 |