Consistent success in life-supporting porcine cardiac xenotransplantation M Längin, T Mayr, B Reichart, S Michel, S Buchholz, S Guethoff, ... Nature 564 (7736), 430-433, 2018 | 486 | 2018 |
Transgenic pigs as models for translational biomedical research B Aigner, S Renner, B Kessler, N Klymiuk, M Kurome, A Wünsch, E Wolf Journal of molecular medicine 88, 653-664, 2010 | 358 | 2010 |
Birth of offspring following transplantation of cryopreserved immature testicular pieces and in-vitro microinsemination T Shinohara, K Inoue, N Ogonuki, M Kanatsu-Shinohara, H Miki, K Nakata, ... Human reproduction 17 (12), 3039-3045, 2002 | 330 | 2002 |
Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy A Moretti, L Fonteyne, F Giesert, P Hoppmann, AB Meier, T Bozoglu, ... Nature medicine 26 (2), 207-214, 2020 | 224 | 2020 |
Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle N Klymiuk, A Blutke, A Graf, S Krause, K Burkhardt, A Wuensch, S Krebs, ... Human molecular genetics 22 (21), 4368-4382, 2013 | 190 | 2013 |
Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing K Fischer, S Kraner-Scheiber, B Petersen, B Rieblinger, A Buermann, ... Scientific reports 6 (1), 29081, 2016 | 177 | 2016 |
Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice N Klymiuk, L Van Buerck, A Bähr, M Offers, B Kessler, A Wuensch, ... Diabetes 61 (6), 1527-1532, 2012 | 156 | 2012 |
A porcine model of familial adenomatous polyposis T Flisikowska, C Merkl, M Landmann, S Eser, N Rezaei, X Cui, M Kurome, ... Gastroenterology 143 (5), 1173-1175. e7, 2012 | 155 | 2012 |
Production of transgenic-clone pigs by the combination of ICSI-mediated gene transfer with somatic cell nuclear transfer M Kurome, H Ueda, R Tomii, K Naruse, H Nagashima Transgenic research 15, 229-240, 2006 | 146 | 2006 |
Cryopreservation of porcine embryos derived from in vitro-matured oocytes R Esaki, H Ueda, M Kurome, K Hirakawa, R Tomii, H Yoshioka, ... Biology of reproduction 71 (2), 432-437, 2004 | 134 | 2004 |
Permanent Neonatal Diabetes in INSC94Y Transgenic Pigs S Renner, C Braun-Reichhart, A Blutke, N Herbach, D Emrich, E Streckel, ... Diabetes 62 (5), 1505-1511, 2013 | 130 | 2013 |
Dominant-negative mutant hepatocyte nuclear factor 1α induces diabetes in transgenic-cloned pigs K Umeyama, M Watanabe, H Saito, M Kurome, S Tohi, H Matsunari, ... Transgenic research 18, 697-706, 2009 | 125 | 2009 |
Development of efficient strategies for the production of genetically modified pigs H Nagashima, T Fujimura, Y Takahagi, M Kurome, N Wako, T Ochiai, ... Theriogenology 59 (1), 95-106, 2003 | 111 | 2003 |
Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis N Klymiuk, L Mundhenk, K Kraehe, A Wuensch, S Plog, D Emrich, ... Journal of molecular medicine 90, 597-608, 2012 | 109 | 2012 |
Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set M Kurome, L Geistlinger, B Kessler, V Zakhartchenko, N Klymiuk, ... BMC biotechnology 13, 1-13, 2013 | 108 | 2013 |
Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2 K Fischer, B Rieblinger, R Hein, R Sfriso, J Zuber, A Fischer, B Klinger, ... Xenotransplantation 27 (1), e12560, 2020 | 105 | 2020 |
Production of live piglets following cryopreservation of embryos derived from in vitro-matured oocytes H Nagashima, K Hiruma, H Saito, R Tomii, S Ueno, N Nakayama, ... Biology of Reproduction 76 (5), 900-905, 2007 | 98 | 2007 |
Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs S Leuchs, A Saalfrank, C Merkl, T Flisikowska, M Edlinger, M Durkovic, ... Public Library of Science 7 (10), e43323, 2012 | 92 | 2012 |
Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver A Hinrichs, B Kessler, M Kurome, A Blutke, E Kemter, M Bernau, ... Molecular metabolism 11, 113-128, 2018 | 91 | 2018 |
Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single-and multitransgenic pigs A Wuensch, A Baehr, AK Bongoni, E Kemter, A Blutke, W Baars, S Haertle, ... Transplantation 97 (2), 138-147, 2014 | 90 | 2014 |