| Adenosine deaminase: functional implications and different classes of inhibitors G Cristalli, S Costanzi, C Lambertucci, G Lupidi, S Vittori, R Volpini, ... Medicinal research reviews 21 (2), 105-128, 2001 | 437 | 2001 |
| Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation G Trivellin, AF Daly, FR Faucz, B Yuan, L Rostomyan, DO Larco, ... New England Journal of Medicine 371 (25), 2363-2374, 2014 | 335 | 2014 |
| Nerve agents: what they are, how they work, how to counter them S Costanzi, JH Machado, M Mitchell ACS chemical neuroscience 9 (5), 873-885, 2018 | 188 | 2018 |
| Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling S Costanzi, L Mamedova, ZG Gao, KA Jacobson Journal of medicinal chemistry 47 (22), 5393-5404, 2004 | 178 | 2004 |
| Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening IG Tikhonova, CS Sum, S Neumann, S Engel, BM Raaka, S Costanzi, ... Journal of medicinal chemistry 51 (3), 625-633, 2008 | 171 | 2008 |
| On the Applicability of GPCR Homology Models to Computer-Aided Drug Discovery: A Comparison between In Silico and Crystal Structures of the β2-Adrenergic … S Costanzi Journal of medicinal chemistry 51 (10), 2907-2914, 2008 | 162 | 2008 |
| Prediction of passive blood–brain partitioning: straightforward and effective classification models based on in silico derived physicochemical descriptors S Vilar, M Chakrabarti, S Costanzi Journal of Molecular Graphics and Modelling 28 (8), 899-903, 2010 | 145 | 2010 |
| Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3 … J Jiang, K Ghoreschi, F Deflorian, Z Chen, M Perreira, M Pesu, J Smith, ... Journal of medicinal chemistry 51 (24), 8012-8018, 2008 | 144 | 2008 |
| Identification of residues important for agonist recognition and activation in GPR40 CS Sum, IG Tikhonova, S Neumann, S Engel, BM Raaka, S Costanzi, ... Journal of Biological Chemistry 282 (40), 29248-29255, 2007 | 141 | 2007 |
| Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library S Ahn, AW Kahsai, B Pani, QT Wang, S Zhao, AL Wall, RT Strachan, ... Proceedings of the National Academy of Sciences 114 (7), 1708-1713, 2017 | 134 | 2017 |
| N 6-Alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A3 receptor and a starting point for searching A2B ligands R Volpini, S Costanzi, C Lambertucci, S Taffi, S Vittori, KN Klotz, G Cristalli Journal of medicinal chemistry 45 (15), 3271-3279, 2002 | 126 | 2002 |
| A2B adenosine receptor blockade inhibits growth of prostate cancer cells Q Wei, S Costanzi, R Balasubramanian, ZG Gao, KA Jacobson Purinergic signalling 9, 271-280, 2013 | 121 | 2013 |
| A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin … H Jäschke, S Neumann, S Moore, CJ Thomas, AO Colson, S Costanzi, ... Journal of Biological Chemistry 281 (15), 9841-9844, 2006 | 116 | 2006 |
| A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism S Neumann, G Kleinau, S Costanzi, S Moore, J Jiang, BM Raaka, ... Endocrinology 149 (12), 5945-5950, 2008 | 113 | 2008 |
| Medicinal chemistry and pharmacology of A2B adenosine receptors R Volpini, S Costanzi, S Vittori, G Cristalli, KN Klotz Current topics in medicinal chemistry 3 (4), 427-443, 2003 | 113 | 2003 |
| Bidirectional, iterative approach to the structural delineation of the functional “chemoprint” in GPR40 for agonist recognition IG Tikhonova, CS Sum, S Neumann, CJ Thomas, BM Raaka, S Costanzi, ... Journal of medicinal chemistry 50 (13), 2981-2989, 2007 | 112 | 2007 |
| Synthesis and Biological Activity of a New Series of N 6-Arylcarbamoyl, 2-(Ar) alkynyl-N 6-arylcarbamoyl, and N 6-Carboxamido Derivatives of Adenosine-5 ‘-N-ethyluronamide as … PG Baraldi, B Cacciari, MJ Pineda de Las Infantas, R Romagnoli, ... Journal of medicinal chemistry 41 (17), 3174-3185, 1998 | 112 | 1998 |
| New substituted 9-alkylpurines as adenosine receptor ligands E Camaioni, S Costanzi, S Vittori, R Volpini, KN Klotz, G Cristalli Bioorganic & medicinal chemistry 6 (5), 523-533, 1998 | 111 | 1998 |
| New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors KA Jacobson, S Costanzi Molecular pharmacology 82 (3), 361-371, 2012 | 105 | 2012 |
| Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure− activity relationships and selective … S Moore, H Jaeschke, G Kleinau, S Neumann, S Costanzi, J Jiang, ... Journal of medicinal chemistry 49 (13), 3888-3896, 2006 | 105 | 2006 |
