Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a) D Singh, J Mallon, A Poddar, Y Wang, R Tippana, O Yang, S Bailey, T Ha Proceedings of the National Academy of Sciences 115 (21), 5444-5449, 2018 | 173 | 2018 |
Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis D Singh, Y Wang, J Mallon, O Yang, J Fei, A Poddar, D Ceylan, S Bailey, ... Nature structural & molecular biology 25 (4), 347-354, 2018 | 118 | 2018 |
Mimicking co-transcriptional RNA folding using a superhelicase B Hua, S Panja, S Woodson, T Ha Biophysical Journal 114 (3), 433a-434a, 2018 | 46 | 2018 |
Single molecule analysis of effects of non-canonical guide RNAs and specificity-enhancing mutations on Cas9-induced DNA unwinding IC Okafor, D Singh, Y Wang, M Jung, H Wang, J Mallon, S Bailey, JK Lee, ... Nucleic acids research 47 (22), 11880-11888, 2019 | 39 | 2019 |
Genome oligopaint via local denaturation fluorescence in situ hybridization Y Wang, WT Cottle, H Wang, XA Feng, J Mallon, M Gavrilov, S Bailey, ... Molecular cell 81 (7), 1566-1577. e8, 2021 | 26 | 2021 |
Real-time observation of Cas9 postcatalytic domain motions Y Wang, J Mallon, H Wang, D Singh, M Hyun Jo, B Hua, S Bailey, T Ha Proceedings of the National Academy of Sciences 118 (2), e2010650118, 2021 | 26 | 2021 |
The single-molecule centroid localization algorithm improves the accuracy of fluorescence binding assays B Hua, Y Wang, S Park, KY Han, D Singh, JH Kim, W Cheng, T Ha Biochemistry 57 (10), 1572-1576, 2018 | 9 | 2018 |
HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing G Reginato, MR Dello Stritto, Y Wang, J Hao, R Pavani, M Schmitz, ... Nature Communications 15 (1), 5789, 2024 | 3 | 2024 |
Achieving single nucleotide sensitivity in direct hybridization genome imaging Y Wang, WT Cottle, H Wang, M Gavrilov, RS Zou, MT Pham, ... Nature communications 13 (1), 7776, 2022 | 3 | 2022 |