Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction DA Deshpande, WCH Wang, EL McIlmoyle, KS Robinett, RM Schillinger, ... Nature medicine 16 (11), 1299-1304, 2010 | 709 | 2010 |
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65 XP Huang, J Karpiak, WK Kroeze, H Zhu, X Chen, SS Moy, KA Saddoris, ... Nature 527 (7579), 477-483, 2015 | 261 | 2015 |
CD38‐cyclic ADP‐ribose‐mediated Ca2+ signaling contributes to airway smooth muscle hyperresponsiveness DA Deshpande, TF Walseth, RA Panettieri, MS Kannan The FASEB Journal 17 (3), 1-25, 2003 | 239 | 2003 |
IL‐13 enhances agonist‐evoked calcium signals and contractile responses in airway smooth muscle O Tliba, D Deshpande, H Chen, C Van Besien, M Kannan, ... British journal of pharmacology 140 (7), 1159-1162, 2003 | 217 | 2003 |
Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway DA Deshpande, S Dogan, TF Walseth, SM Miller, Y Amrani, RA Panettieri, ... American journal of respiratory cell and molecular biology 31 (1), 36-42, 2004 | 198 | 2004 |
CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle DA Deshpande, TA White, S Dogan, TF Walseth, RA Panettieri, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 288 (5 …, 2005 | 153 | 2005 |
Targeting G protein-coupled receptor signaling in asthma DA Deshpande, RB Penn Cellular signalling 18 (12), 2105-2120, 2006 | 148 | 2006 |
Autophagy activation in asthma airways remodeling KD McAlinden, DA Deshpande, S Ghavami, D Xenaki, SS Sohal, ... American journal of respiratory cell and molecular biology 60 (5), 541-553, 2019 | 126 | 2019 |
The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH H Saxena, DA Deshpande, BC Tiegs, H Yan, RJ Battafarano, ... British journal of pharmacology 166 (3), 981-990, 2012 | 115 | 2012 |
β-Agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent SJ Morgan, DA Deshpande, BC Tiegs, AM Misior, H Yan, AV Hershfeld, ... Journal of Biological Chemistry 289 (33), 23065-23074, 2014 | 101 | 2014 |
β-Arrestins specifically constrain β2-adrenergic receptor signaling and function in airway smooth muscle DA Deshpande, BS Theriot, RB Penn, JKL Walker FASEB journal: official publication of the Federation of American Societies …, 2008 | 101 | 2008 |
Altered airway responsiveness in CD38-deficient mice DA Deshpande, TA White, AGP Guedes, C Milla, TF Walseth, FE Lund, ... American journal of respiratory cell and molecular biology 32 (2), 149-156, 2005 | 100 | 2005 |
Bitter taste receptor agonists mitigate features of allergic asthma in mice P Sharma, R Yi, AP Nayak, N Wang, F Tang, MJ Knight, S Pan, B Oliver, ... Scientific reports 7 (1), 46166, 2017 | 98 | 2017 |
Transcriptional regulation of CD38 expression by tumor necrosis factor‐α in human airway smooth muscle cells: role of NF‐κB and sensitivity to glucocorticoids BN Kang, KG Tirumurugaan, DA Deshpande, Y Amrani, RA Panettieri, ... The FASEB journal 20 (7), 1000-1002, 2006 | 87 | 2006 |
Bronchial hyperresponsiveness: insights into new signaling molecules Y Amrani, O Tliba, DA Deshpande, TF Walseth, MS Kannan, ... Current opinion in pharmacology 4 (3), 230-234, 2004 | 84 | 2004 |
Anti-mitogenic effects of β-agonists and PGE2 on airway smooth muscle are PKA dependent H Yan, DA Deshpande, AM Misior, MC Miles, H Saxena, EC Riemer, ... The FASEB Journal 25 (1), 389, 2011 | 76 | 2011 |
Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling S Naik, CK Billington, RM Pascual, DA Deshpande, FP Stefano, ... Journal of Biological Chemistry 280 (10), 8722-8732, 2005 | 74 | 2005 |
Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors KS Robinett, DA Deshpande, MM Malone, SB Liggett American journal of respiratory cell and molecular biology 45 (5), 1069-1074, 2011 | 69 | 2011 |
Glucocorticoid-and protein kinase A–dependent transcriptome regulation in airway smooth muscle AM Misior, DA Deshpande, MJ Loza, RM Pascual, JD Hipp, RB Penn American journal of respiratory cell and molecular biology 41 (1), 24-39, 2009 | 65 | 2009 |
Bronchodilator activity of bitter tastants in human tissue DA Deshpande, KS Robinett, WCH Wang, JSK Sham, SS An, SB Liggett Nature medicine 17 (7), 776-778, 2011 | 64 | 2011 |