A microRNA component of the p53 tumour suppressor network L He, X He, LP Lim, E De Stanchina, Z Xuan, Y Liang, W Xue, L Zender, ... Nature 447 (7148), 1130-1134, 2007 | 3374 | 2007 |
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas W Xue, L Zender, C Miething, RA Dickins, E Hernando, V Krizhanovsky, ... Nature 445 (7128), 656-660, 2007 | 2894 | 2007 |
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach L Zender, MS Spector, W Xue, P Flemming, C Cordon-Cardo, J Silke, ... Cell 125 (7), 1253-1267, 2006 | 1261 | 2006 |
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype H Yin, W Xue, S Chen, RL Bogorad, E Benedetti, M Grompe, ... Nature biotechnology 32 (6), 551-553, 2014 | 1222 | 2014 |
Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo H Yin, CQ Song, JR Dorkin, LJ Zhu, Y Li, Q Wu, A Park, J Yang, S Suresh, ... Nature biotechnology 34 (3), 328-333, 2016 | 976 | 2016 |
CRISPR-mediated direct mutation of cancer genes in the mouse liver W Xue, S Chen, H Yin, T Tammela, T Papagiannakopoulos, NS Joshi, ... Nature 514 (7522), 380-384, 2014 | 893 | 2014 |
KRAS and YAP1 converge to regulate EMT and tumor survival DD Shao, W Xue, EB Krall, A Bhutkar, F Piccioni, X Wang, AC Schinzel, ... Cell 158 (1), 171-184, 2014 | 754 | 2014 |
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing H Yin, CQ Song, S Suresh, Q Wu, S Walsh, LH Rhym, E Mintzer, ... Nature biotechnology 35 (12), 1179-1187, 2017 | 508 | 2017 |
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer L Zender, W Xue, J Zuber, CP Semighini, A Krasnitz, B Ma, P Zender, ... Cell 135 (5), 852-864, 2008 | 508 | 2008 |
Rapid modelling of cooperating genetic events in cancer through somatic genome editing FJ Sánchez-Rivera, T Papagiannakopoulos, R Romero, T Tammela, ... Nature 516 (7531), 428-431, 2014 | 437 | 2014 |
Adenovirus-mediated somatic genome editing of Pten by CRISPR/Cas9 in mouse liver in spite of Cas9-specific immune responses D Wang, H Mou, S Li, Y Li, S Hough, K Tran, J Li, H Yin, DG Anderson, ... Human gene therapy 26 (7), 432-442, 2015 | 404 | 2015 |
Topoisomerase levels determine chemotherapy response in vitro and in vivo DJ Burgess, J Doles, L Zender, W Xue, B Ma, WR McCombie, GJ Hannon, ... Proceedings of the National Academy of Sciences 105 (26), 9053-9058, 2008 | 394 | 2008 |
p53 represses the mevalonate pathway to mediate tumor suppression SH Moon, CH Huang, SL Houlihan, K Regunath, WA Freed-Pastor, ... Cell 176 (3), 564-580. e19, 2019 | 342 | 2019 |
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma T Tammela, FJ Sanchez-Rivera, NM Cetinbas, K Wu, NS Joshi, ... Nature 545 (7654), 355-359, 2017 | 327 | 2017 |
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis M Gyrd-Hansen, M Darding, M Miasari, MM Santoro, L Zender, W Xue, ... Nature cell biology 10 (11), 1309-1317, 2008 | 325 | 2008 |
Small RNA combination therapy for lung cancer W Xue, JE Dahlman, T Tammela, OF Khan, S Sood, A Dave, W Cai, ... Proceedings of the National Academy of Sciences 111 (34), E3553-E3561, 2014 | 269 | 2014 |
p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer DF Tschaharganeh, W Xue, DF Calvisi, M Evert, TV Michurina, LE Dow, ... Cell 158 (3), 579-592, 2014 | 257 | 2014 |
A compact, high-accuracy Cas9 with a dinucleotide PAM for in vivo genome editing A Edraki, A Mir, R Ibraheim, I Gainetdinov, Y Yoon, CQ Song, Y Cao, ... Molecular cell 73 (4), 714-726. e4, 2019 | 250 | 2019 |
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity H Yin, CQ Song, S Suresh, SY Kwan, Q Wu, S Walsh, J Ding, RL Bogorad, ... Nature chemical biology 14 (3), 311-316, 2018 | 241 | 2018 |
DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma W Xue, A Krasnitz, R Lucito, R Sordella, L VanAelst, C Cordon-Cardo, ... Genes & development 22 (11), 1439-1444, 2008 | 225 | 2008 |