Histidine-aromatic interactions in barnase: Elevation of histidine pKa and contribution to protein stability R Loewenthal, J Sancho, AR Fersht Journal of molecular biology 224 (3), 759-770, 1992 | 272 | 1992 |
Effect of alanine versus glycine in α-helices on protein stability L Serrano, JL Neira, J Sancho, AR Fersht Nature Publishing Group 356 (6368), 453-455, 1992 | 268 | 1992 |
α-Helix stability in proteins: I. Empirical correlations concerning substitution of side-chains at the N and C-caps and the replacement of alanine by glycine or serine at … L Serrano, J Sancho, M Hirshberg, AR Fersht Journal of molecular biology 227 (2), 544-559, 1992 | 259 | 1992 |
Flavodoxins: sequence, folding, binding, function and beyond J Sancho Cellular and Molecular Life Sciences CMLS 63 (7-8), 855-864, 2006 | 213 | 2006 |
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons J Pujols, S Peña-Díaz, DF Lázaro, F Peccati, F Pinheiro, D González, ... Proceedings of the National Academy of Sciences 115 (41), 10481-10486, 2018 | 206 | 2018 |
Circular dichroism studies of barnase and its mutants: characterization of the contribution of aromatic side chains S Vuilleumier, J Sancho, R Loewenthal, AR Fersht Biochemistry 32 (39), 10303-10313, 1993 | 199 | 1993 |
Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria AL Pey, M Ying, N Cremades, A Velazquez-Campoy, T Scherer, B Thöny, ... The Journal of clinical investigation 118 (8), 2858-2867, 2008 | 192 | 2008 |
Fluorescence spectrum of barnase: contributions of three tryptophan residues and a histidine-related pH dependence R Loewenthal, J Sancho, AR Fersht Biochemistry 30 (27), 6775-6779, 1991 | 169 | 1991 |
Histidine residues at the N-and C-termini of alpha-helices: perturbed pKas and protein stability. J Sancho, L Serrano, AR Fersht Biochemistry 31 (8), 2253-2258, 1992 | 168 | 1992 |
Miglustat (NB-DNJ) works as a chaperone for mutated acid β-glucosidase in cells transfected with several Gaucher disease mutations P Alfonso, S Pampín, J Estrada, JC Rodríguez-Rey, P Giraldo, J Sancho, ... Blood Cells, Molecules, and Diseases 35 (2), 268-276, 2005 | 161 | 2005 |
The tryptophan/histidine interaction in α-helices J Fernández-Recio, A Vázquez, C Civera, P Sevilla, J Sancho Journal of molecular biology 267 (1), 184-197, 1997 | 119 | 1997 |
Differential stabilization of the three FMN redox forms by tyrosine 94 and tryptophan 57 in flavodoxin from Anabaena and its influence on the redox potentials A Lostao, C Gómez-Moreno, SG Mayhew, J Sancho Biochemistry 36 (47), 14334-14344, 1997 | 117 | 1997 |
Long-range surface charge-charge interactions in proteins: comparison of experimental results with calculations from a theoretical method R Loewenthal, J Sancho, T Reinikainen, AR Fersht Journal of molecular biology 232 (2), 574-583, 1993 | 111 | 1993 |
The active site of pepsin is formed in the intermediate conformation dominant at mildly acidic pH LA Campos, J Sancho FEBS letters 538 (1-3), 89-95, 2003 | 109 | 2003 |
Closure of a tyrosine/tryptophan aromatic gate leads to a compact fold in apo flavodoxin CG Genzor, A Perales-Alcón, J Sancho, A Romero Nature Structural Biology 3 (4), 329-332, 1996 | 106 | 1996 |
An N-terminal fragment of barnase has residual helical structure similar to that in a refolding intermediate J Sancho, JL Neira, AR Fersht Journal of molecular biology 224 (3), 749-758, 1992 | 106 | 1992 |
Dissection of an enzyme by protein engineering: the N and C-terminal fragments of barnase form a native-like complex with restored enzymic activity J Sancho, AR Fersht Journal of molecular biology 224 (3), 741-747, 1992 | 103 | 1992 |
ProtSA: a web application for calculating sequence specific protein solvent accessibilities in the unfolded ensemble J Estrada, P Bernadó, M Blackledge, J Sancho BMC bioinformatics 10 (1), 1, 2009 | 100 | 2009 |
Folding of barnase in parts AD Kippen, J Sancho, AR Fersht Biochemistry 33 (12), 3778-3786, 1994 | 98 | 1994 |
An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA R Acín-Pérez, MP Bayona-Bafaluy, M Bueno, C Machicado, ... Human molecular genetics 12 (3), 329-339, 2003 | 97 | 2003 |