Modelling Myc inhibition as a cancer therapy L Soucek, J Whitfield, CP Martins, AJ Finch, DJ Murphy, NM Sodir, ... Nature 455 (7213), 679-683, 2008 | 957 | 2008 |
Distinct thresholds govern Myc's biological output in vivo DJ Murphy, MR Junttila, L Pouyet, A Karnezis, K Shchors, DA Bui, ... Cancer cell 14 (6), 447-457, 2008 | 509 | 2008 |
Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death G Ichim, J Lopez, SU Ahmed, N Muthalagu, E Giampazolias, ME Delgado, ... Molecular cell 57 (5), 860-872, 2015 | 418 | 2015 |
Deregulated MYC expression induces dependence upon AMPK-related kinase 5 L Liu, J Ulbrich, J Müller, T Wüstefeld, L Aeberhard, TR Kress, ... Nature 483 (7391), 608-612, 2012 | 303 | 2012 |
MYC-dependent regulation and prognostic role of CIP2A in gastric cancer A Khanna, C Böckelman, A Hemmes, MR Junttila, JP Wiksten, M Lundin, ... JNCI: Journal of the National Cancer Institute 101 (11), 793-805, 2009 | 268 | 2009 |
Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age-and Tissue-Specific Sensitivity to Cancer Therapeutics KA Sarosiek, C Fraser, N Muthalagu, PD Bhola, W Chang, SK McBrayer, ... Cancer Cell, 2016 | 241 | 2016 |
Interleukin-6-and cyclic AMP-mediated signaling potentiates neuroendocrine differentiation of LNCaP prostate tumor cells PD Deeble, DJ Murphy, SJ Parsons, ME Cox Molecular and cellular biology 21 (24), 8471-8482, 2001 | 238 | 2001 |
Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation AJ Bott, IC Peng, Y Fan, B Faubert, L Zhao, J Li, S Neidler, Y Sun, N Jaber, ... Cell metabolism 22 (6), 1068-1077, 2015 | 235 | 2015 |
Human SWI-SNF component BRG1 represses transcription of the c-fos gene DJ Murphy, S Hardy, DA Engel Molecular and cellular biology 19 (4), 2724-2733, 1999 | 182 | 1999 |
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism AJ Bott, J Shen, C Tonelli, L Zhan, N Sivaram, YP Jiang, X Yu, V Bhatt, ... Cell reports 29 (5), 1287-1298. e6, 2019 | 137 | 2019 |
Repression of the type I interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in pancreatic ductal adenocarcinoma N Muthalagu, T Monteverde, X Raffo-Iraolagoitia, R Wiesheu, D Whyte, ... Cancer Discovery, 2020 | 122 | 2020 |
Apoptotic cell death in disease—Current understanding of the NCCD 2023 I Vitale, F Pietrocola, E Guilbaud, SA Aaronson, JM Abrams, D Adam, ... Cell Death & Differentiation 30 (5), 1097-1154, 2023 | 114 | 2023 |
The ERBB network facilitates KRAS-driven lung tumorigenesis B Kruspig, T Monteverde, S Neidler, A Hock, E Kerr, C Nixon, W Clark, ... Science Translational Medicine 10 (446), eaao2565, 2018 | 106 | 2018 |
MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance AS Farrell, AD Rhim, BC Sheppard, BL Allen-Petersen, C Pelz, ... Nature Communications 8, 1728, 2017 | 98 | 2017 |
Evidence of cancer‐promoting roles for AMPK and related kinases T Monteverde, N Muthalagu, J Port, DJ Murphy The FEBS journal 282 (24), 4658-4671, 2015 | 95 | 2015 |
A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila JBC Alessandro Scopelliti, Christin Bauer, Yachuan Yu, Tong Zhang, Bjo ̈rn ... Cell Metabolism 29, 2019 | 89 | 2019 |
CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity JB Walton, M Farquharson, S Mason, J Port, B Kruspig, S Dowson, ... Scientific Reports 7, 16827, 2017 | 85 | 2017 |
BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues N Muthalagu, MR Junttila, KE Wiese, E Wolf, J Morton, B Bauer, GI Evan, ... Cell reports 8 (5), 1347-1353, 2014 | 83 | 2014 |
Defining the temporal requirements for Myc in the progression and maintenance of skin neoplasia I Flores, DJ Murphy, LB Swigart, U Knies, GI Evan Oncogene 23 (35), 5923-5930, 2004 | 80 | 2004 |
In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells C Leikam, AL Hufnagel, C Otto, DJ Murphy, B Mühling, S Kneitz, I Nanda, ... Cell death & disease 6 (4), e1711, 2015 | 77 | 2015 |