Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB T Eicher, MA Seeger, C Anselmi, W Zhou, L Brandstätter, F Verrey, ... Elife 3, e03145, 2014 | 190 | 2014 |
High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane AP Srivastava, M Luo, W Zhou, J Symersky, D Bai, MG Chambers, ... Science 360 (6389), eaas9699, 2018 | 188 | 2018 |
Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery CM Guardia, XF Tan, T Lian, MS Rana, W Zhou, ET Christenson, ... Cell reports 31 (13), 2020 | 123 | 2020 |
Atomistic simulations indicate the c-subunit ring of the F1Fo ATP synthase is not the mitochondrial permeability transition pore W Zhou, F Marinelli, C Nief, JD Faraldo-Gómez Elife 6, e23781, 2017 | 85 | 2017 |
Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β–mediated colitis L Mao, A Kitani, E Hiejima, K Montgomery-Recht, W Zhou, I Fuss, ... The Journal of clinical investigation 130 (4), 1793-1807, 2020 | 75 | 2020 |
High-resolution structure and mechanism of an F/V-hybrid rotor ring in a Na+-coupled ATP synthase D Matthies, W Zhou, AL Klyszejko, C Anselmi, Ö Yildiz, K Brandt, V Müller, ... Nature communications 5, 2014 | 72 | 2014 |
Large-scale state-dependent membrane remodeling by a transporter protein W Zhou, G Fiorin, C Anselmi, HA Karimi-Varzaneh, H Poblete, LR Forrest, ... Elife 8, e50576, 2019 | 48 | 2019 |
TRPV1 pore turret dictates distinct DkTx and capsaicin gating M Geron, R Kumar, W Zhou, JD Faraldo-Gómez, V Vásquez, A Priel Proceedings of the National Academy of Sciences 115 (50), E11837-E11846, 2018 | 43 | 2018 |
Bedaquiline inhibits the yeast and human mitochondrial ATP synthases M Luo, W Zhou, H Patel, AP Srivastava, J Symersky, MM Bonar, ... Communications Biology 3 (1), 452, 2020 | 42 | 2020 |
Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry T Dixon, D MacPherson, B Mostofian, T Dauzhenka, S Lotz, D McGee, ... Nature communications 13 (1), 5884, 2022 | 32 | 2022 |
Broadly conserved Na+-binding site in the N-lobe of prokaryotic multidrug MATE transporters E Ficici, W Zhou, S Castellano, JD Faraldo-Gómez Proceedings of the National Academy of Sciences 115 (27), E6172-E6181, 2018 | 32 | 2018 |
Calcineurin regulatory subunit B is a unique calcium sensor that regulates calcineurin in both calcium‐dependent and calcium‐independent manner J Li, ZG Jia, WC Zhou, Q Wei Proteins: Structure, Function, and Bioinformatics 77 (3), 612-623, 2009 | 24 | 2009 |
Characterization of essential domains in HSD17B13 for cellular localization and enzymatic activity Y Ma, S Karki, PM Brown, DD Lin, MC Podszun, W Zhou, OV Belyaeva, ... Journal of Lipid Research 61 (11), 1400-1409, 2020 | 20 | 2020 |
Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter TM Thaker, S Mishra, W Zhou, M Mohan, Q Tang, JD Faraldo-Goméz, ... Nature chemical biology 18 (2), 226-235, 2022 | 19 | 2022 |
DFT studies of the degradation mechanism of methyl mercury activated by a sulfur-rich ligand X Li, RZ Liao, W Zhou, G Chen Physical Chemistry Chemical Physics 12 (16), 3961-3971, 2010 | 16 | 2010 |
Conserved binding site in the N-lobe of prokaryotic MATE transporters suggests a role for Na+ in ion-coupled drug efflux S Castellano, DP Claxton, E Ficici, T Kusakizako, R Stix, W Zhou, ... Journal of Biological Chemistry 296, 2021 | 12 | 2021 |
Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K+ channel TMEM175 SC Oh, F Marinelli, W Zhou, J Lee, HJ Choi, M Kim, JD Faraldo-Gómez, ... eLife 11, e75122, 2022 | 11 | 2022 |
Membrane plasticity facilitates recognition of the inhibitor oligomycin by the mitochondrial ATP synthase rotor W Zhou, JD Faraldo-Gómez Biochimica et Biophysica Acta (BBA)-Bioenergetics 1859 (9), 789-796, 2018 | 11 | 2018 |
The structure of human ATG9A and its interplay with the lipid bilayer CM Guardia, ET Christenson, W Zhou, XF Tan, T Lian, JD Faraldo-Gómez, ... Autophagy 16 (12), 2292-2293, 2020 | 7 | 2020 |
Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175 SC Oh, R Stix, W Zhou, JD Faraldo-Gómez, RK Hite Proceedings of the National Academy of Sciences 119 (44), e2208882119, 2022 | 6 | 2022 |