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Sam Lear
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Pep-Calc. com: a set of web utilities for the calculation of peptide and peptoid properties and automatic mass spectral peak assignment
S Lear, SL Cobb
Journal of computer-aided molecular design 30, 271-277, 2016
1202016
Total chemical synthesis of lassomycin and lassomycin-amide
S Lear, T Munshi, AS Hudson, C Hatton, J Clardy, JA Mosely, TJ Bull, ...
Organic & biomolecular chemistry 14 (19), 4534-4541, 2016
632016
EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein–Barr virus
L Jiang, R Lan, T Huang, CF Chan, H Li, S Lear, J Zong, WY Wong, ...
Nature Biomedical Engineering 1 (4), 0042, 2017
362017
Engineering PEG-fatty acid stapled, long-acting peptide agonists for G protein-coupled receptors
S Lear, Z Amso, W Shen
Methods in enzymology 622, 183-200, 2019
182019
Engineering of a potent, long-acting NPY2R agonist for combination with a GLP-1R agonist as a multi-hormonal treatment for obesity
S Lear, E Pflimlin, Z Zhou, D Huang, S Weng, V Nguyen-Tran, SB Joseph, ...
Journal of Medicinal Chemistry 63 (17), 9660-9671, 2020
172020
Design of a long-acting and selective MEG-fatty acid stapled prolactin-releasing peptide analog
E Pflimlin, S Lear, C Lee, S Yu, H Zou, A To, S Joseph, V Nguyen-Tran, ...
ACS Medicinal Chemistry Letters 10 (8), 1166-1172, 2019
122019
Directional Plk1 inhibition-driven cell cycle interruption using amphiphilic thin-coated peptide-lanthanide upconversion nanomaterials as in vivo tumor suppressors
CF Chan, R Lan, MK Tsang, D Zhou, S Lear, WL Chan, SL Cobb, ...
Journal of Materials Chemistry B 3 (13), 2624-2634, 2015
112015
Monitoring and inhibition of Plk1: amphiphilic porphyrin conjugated Plk1 specific peptides for its imaging and anti-tumor function
H Li, CF Chan, WL Chan, S Lear, SL Cobb, NK Mak, TCK Lau, R Lan, ...
Organic & Biomolecular Chemistry 12 (31), 5876-5882, 2014
112014
Molecular interaction site on procoagulant myosin for factor Xa–dependent prothrombin activation
H Deguchi, Z Guo, M Hayat, E Pflimlin, S Lear, W Shen, JH Griffin
Journal of Biological Chemistry 294 (41), 15176-15181, 2019
92019
The effects of morphology and linker length on the properties of peptide–lanthanide upconversion nanomaterials as G2 phase cell cycle inhibitors
CF Chan, C Xie, MK Tsang, S Lear, L Dai, Y Zhou, J Cicho, M Karbowiak, ...
European Journal of Inorganic Chemistry 2015 (27), 4539-4545, 2015
92015
Recombinant expression and stapling of a novel long-acting GLP-1R Peptide agonist
S Lear, H Seo, C Lee, L Lei, Z Amso, D Huang, H Zou, Z Zhou, ...
Molecules 25 (11), 2508, 2020
42020
Peptide conjugates and methods of use
W Shen, E Pflimlin, S Lear, A Zaid, PG Schultz
US Patent App. 17/782,573, 2023
2023
Immune checkpoint blocking bispecific molecules
P Schultz, F Wang, RC Fang, YJ Cao, W Shen, X Lyu, S Lear
US Patent App. 17/621,410, 2022
2022
Myosin Derived Peptides and Related Compounds with Anticoagulant Activities
JH Griffin, H Deguchi, W Shen, S Lear, E Pflimlin, YM Angell, ...
US Patent App. 17/824,186, 2022
2022
Total Synthesis of Bioactive Peptides and Whole Proteins
S Lear
Durham University, 2016
2016
Towards a Total Chemical Synthesis of Human CC Motif Chemokine Ligand 2
S Lear
Durham University, 2013
2013
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