Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21 WA McEwan, JCH Tam, RE Watkinson, SR Bidgood, DL Mallery, ... Nature immunology 14 (4), 327-336, 2013 | 390 | 2013 |
Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21 AJ Fletcher, DL Mallery, RE Watkinson, CF Dickson, LC James Proceedings of the National Academy of Sciences 112 (32), 10014-10019, 2015 | 121 | 2015 |
Zoonotic potential of emerging paramyxoviruses: knowns and unknowns PA Thibault, RE Watkinson, A Moreira-Soto, JF Drexler, B Lee Advances in virus research 98, 1-55, 2017 | 120 | 2017 |
LRRK2 phosphorylates novel tau epitopes and promotes tauopathy RM Bailey, JP Covy, HL Melrose, L Rousseau, R Watkinson, J Knight, ... Acta neuropathologica 126, 809-827, 2013 | 111 | 2013 |
Intracellular antibody receptor TRIM21 prevents fatal viral infection M Vaysburd, RE Watkinson, H Cooper, M Reed, K O’Connell, J Smith, ... Proceedings of the National Academy of Sciences 110 (30), 12397-12401, 2013 | 109 | 2013 |
TRIM 21: a cytosolic Fc receptor with broad antibody isotype specificity S Foss, R Watkinson, I Sandlie, LC James, JT Andersen Immunological reviews 268 (1), 328-339, 2015 | 105 | 2015 |
TRIM21 promotes cGAS and RIG-I sensing of viral genomes during infection by antibody-opsonized virus RE Watkinson, WA McEwan, JCH Tam, M Vaysburd, LC James PLoS pathogens 11 (10), e1005253, 2015 | 99 | 2015 |
Ethnic inequalities in health-related quality of life among older adults in England: secondary analysis of a national cross-sectional survey RE Watkinson, M Sutton, AJ Turner The Lancet Public Health 6 (3), e145-e154, 2021 | 88 | 2021 |
Simultaneous neutralization and innate immune detection of a replicating virus by TRIM21 RE Watkinson, JCH Tam, MJ Vaysburd, LC James Journal of virology 87 (13), 7309-7313, 2013 | 47 | 2013 |
Ethnic inequalities in COVID-19 vaccine uptake and comparison to seasonal influenza vaccine uptake in Greater Manchester, UK: A cohort study RE Watkinson, R Williams, S Gillibrand, C Sanders, M Sutton PLoS medicine 19 (3), e1003932, 2022 | 46 | 2022 |
Nipah virus matrix protein: expert hacker of cellular machines RE Watkinson, B Lee FEBS letters 590 (15), 2494-2511, 2016 | 46 | 2016 |
Effects of BNT162b2 mRNA vaccine on COVID-19 infection and hospitalisation amongst older people: matched case control study for England TFD Mason, M Whitston, J Hodgson, RE Watkinson, YS Lau, ... BMC medicine 19, 1-9, 2021 | 44* | 2021 |
TRIM21 immune signaling is more sensitive to antibody affinity than its neutralization activity S Foss, RE Watkinson, A Grevys, MB McAdam, M Bern, LS Høydahl, ... The Journal of Immunology 196 (8), 3452-3459, 2016 | 41 | 2016 |
Dissecting ELANE neutropenia pathogenicity by human HSC gene editing S Rao, Y Yao, JS de Brito, Q Yao, AH Shen, RE Watkinson, AL Kennedy, ... Cell Stem Cell 28 (5), 833-845. e5, 2021 | 33 | 2021 |
Antibody-antigen kinetics constrain intracellular humoral immunity M Bottermann, HE Lode, RE Watkinson, S Foss, I Sandlie, JT Andersen, ... Scientific reports 6 (1), 37457, 2016 | 33 | 2016 |
Socioeconomic inequality in access to timely and appropriate care in emergency departments AJ Turner, I Francetic, R Watkinson, S Gillibrand, M Sutton Journal of Health Economics 85, 102668, 2022 | 23 | 2022 |
Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge S Foss, A Jonsson, M Bottermann, R Watkinson, HE Lode, MB McAdam, ... Science Immunology 7 (70), eabj1640, 2022 | 22 | 2022 |
Intracellular antibody immunity RE Watkinson, WA McEwan, LC James Journal of clinical immunology 34, 30-34, 2014 | 21 | 2014 |
Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase RM Cox, J Sourimant, M Toots, JJ Yoon, S Ikegame, M Govindarajan, ... Nature microbiology 5 (10), 1232-1246, 2020 | 20 | 2020 |
Gene editing ELANE in human hematopoietic stem and progenitor cells reveals disease mechanisms and therapeutic strategies for severe congenital neutropenia S Rao, J Brito-Frazao, AV Serbin, Q Yao, K Luk, Y Wu, J Zeng, C Ren, ... Blood 134, 3, 2019 | 4 | 2019 |