| Synthesis and structure− activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase SH Hwang, KM Wagner, C Morisseau, JY Liu, H Dong, AT Wecksler, ... Journal of medicinal chemistry 54 (8), 3037-3050, 2011 | 180 | 2011 |
| Monoclonal antibody targeting the β-barrel assembly machine of Escherichia coli is bactericidal KM Storek, MR Auerbach, H Shi, NK Garcia, D Sun, NN Nickerson, R Vij, ... Proceedings of the National Academy of Sciences 115 (14), 3692-3697, 2018 | 167 | 2018 |
| Structural basis for dual-mode inhibition of the ABC transporter MsbA H Ho, A Miu, MK Alexander, NK Garcia, A Oh, I Zilberleyb, M Reichelt, ... Nature 557 (7704), 196-201, 2018 | 162 | 2018 |
| Synthesis and biological evaluation of sorafenib-and regorafenib-like sEH inhibitors SH Hwang, AT Wecksler, G Zhang, C Morisseau, LV Nguyen, SH Fu, ... Bioorganic & medicinal chemistry letters 23 (13), 3732-3737, 2013 | 130 | 2013 |
| Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation AT Wecksler, V Kenyon, JD Deschamps, TR Holman Biochemistry 47 (28), 7364-7375, 2008 | 84 | 2008 |
| Effect of ambient light on IgG1 monoclonal antibodies during drug product processing and development A Sreedhara, J Yin, M Joyce, K Lau, AT Wecksler, G Deperalta, L Yi, ... European Journal of Pharmaceutics and Biopharmaceutics 100, 38-46, 2016 | 80 | 2016 |
| Mapping the binding interface of VEGF and a monoclonal antibody Fab-1 fragment with fast photochemical oxidation of proteins (FPOP) and mass spectrometry Y Zhang, AT Wecksler, P Molina, G Deperalta, ML Gross Journal of The American Society for Mass Spectrometry 28 (5), 850-858, 2017 | 72 | 2017 |
| Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy H Inoue, SH Hwang, AT Wecksler, BD Hammock, RH Weiss Cancer biology & therapy 12 (9), 827-836, 2011 | 68 | 2011 |
| A novel p21 attenuator which is structurally related to sorafenib HI Wettersten, S Hee Hwang, C Li, EY Shiu, AT Wecksler, BD Hammock, ... Cancer biology & therapy 14 (3), 278-285, 2013 | 65 | 2013 |
| Mechanistic investigations of human reticulocyte 15-and platelet 12-lipoxygenases with arachidonic acid AT Wecksler, C Jacquot, WA Van Der Donk, TR Holman Biochemistry 48 (26), 6259-6267, 2009 | 59 | 2009 |
| Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2 AT Wecksler, V Kenyon, NK Garcia, JD Deschamps, WA Van Der Donk, ... Biochemistry 48 (36), 8721-8730, 2009 | 52 | 2009 |
| Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation [S] C Morisseau, AT Wecksler, C Deng, H Dong, J Yang, KSS Lee, ... Journal of lipid research 55 (6), 1131-1138, 2014 | 51 | 2014 |
| Characterizing monoclonal antibody structure by carboxyl group footprinting P Kaur, SE Tomechko, J Kiselar, W Shi, G Deperalta, AT Wecksler, ... MAbs 7 (3), 540-552, 2015 | 50 | 2015 |
| Kinetic and spectroscopic studies of N694C lipoxygenase: a probe of the substrate activation mechanism of a nonheme ferric enzyme ML Neidig, AT Wecksler, G Schenk, TR Holman, EI Solomon Journal of the American Chemical Society 129 (24), 7531-7537, 2007 | 50 | 2007 |
| Targeted degradation via direct 26S proteasome recruitment C Bashore, S Prakash, MC Johnson, RJ Conrad, IA Kekessie, SJ Scales, ... Nature Chemical Biology 19 (1), 55-63, 2023 | 42 | 2023 |
| Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12-and 15-lipoxygenases C Jacquot, AT Wecksler, CM McGinley, EN Segraves, TR Holman, ... Biochemistry 47 (27), 7295-7303, 2008 | 42 | 2008 |
| Mapping of Fab-1: VEGF interface using carboxyl group footprinting mass spectrometry AT Wecksler, MS Kalo, G Deperalta Journal of The American Society for Mass Spectrometry 26 (12), 2077-2080, 2015 | 34 | 2015 |
| Characterization of ELISA antibody-antigen interaction using footprinting-mass spectrometry and negative staining transmission electron microscopy M Lin, D Krawitz, MD Callahan, G Deperalta, AT Wecksler Journal of The American Society for Mass Spectrometry 29 (5), 961-971, 2018 | 32 | 2018 |
| Antibody–receptor interactions mediate antibody-dependent cellular cytotoxicity Y Sun, S Izadi, M Callahan, G Deperalta, AT Wecksler Journal of Biological Chemistry 297 (1), 2021 | 31 | 2021 |
| Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1 AT Wecksler, NK Garcia, TR Holman Bioorganic & medicinal chemistry 17 (18), 6534-6539, 2009 | 31 | 2009 |
