Is there new hope for therapeutic matrix metalloproteinase inhibition? RE Vandenbroucke, C Libert Nature reviews Drug discovery 13 (12), 904-927, 2014 | 824 | 2014 |
The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls D Vercauteren, RE Vandenbroucke, AT Jones, J Rejman, J Demeester, ... Molecular Therapy 18 (3), 561-569, 2010 | 795 | 2010 |
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment H Van Hove, L Martens, I Scheyltjens, K De Vlaminck, AR Pombo Antunes, ... Nature neuroscience 22 (6), 1021-1035, 2019 | 720 | 2019 |
Nanobodies as therapeutics: big opportunities for small antibodies S Steeland, RE Vandenbroucke, C Libert Drug discovery today 21 (7), 1076-1113, 2016 | 453 | 2016 |
Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier SE Storck, S Meister, J Nahrath, JN Meißner, N Schubert, A Di Spiezio, ... The Journal of clinical investigation 126 (1), 123-136, 2016 | 400 | 2016 |
The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex type K Von Gersdorff, NN Sanders, R Vandenbroucke, SC De Smedt, ... Molecular therapy 14 (5), 745-753, 2006 | 386 | 2006 |
Intracellularly degradable polyelectrolyte microcapsules BG De Geest, RE Vandenbroucke, AM Guenther, GB Sukhorukov, ... ADVANCED MATERIALS-DEERFIELD BEACH THEN WEINHEIM- 18 (8), 1005, 2006 | 382 | 2006 |
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization AR Pombo Antunes, I Scheyltjens, F Lodi, J Messiaen, A Antoranz, ... Nature neuroscience 24 (4), 595-610, 2021 | 370 | 2021 |
Identification of a novel mechanism of blood–brain communication during peripheral inflammation via choroid plexus‐derived extracellular vesicles S Balusu, E Van Wonterghem, R De Rycke, K Raemdonck, S Stremersch, ... EMBO molecular medicine 8 (10), 1162-1183, 2016 | 339 | 2016 |
Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop AE Russell, A Sneider, KW Witwer, P Bergese, SN Bhattacharyya, ... Journal of extracellular vesicles 8 (1), 1684862, 2019 | 231 | 2019 |
Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases M Brkic, S Balusu, C Libert, RE Vandenbroucke Mediators of inflammation 2015 (1), 620581, 2015 | 225 | 2015 |
Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA I Lentacker, BG De Geest, RE Vandenbroucke, L Peeters, J Demeester, ... Langmuir 22 (17), 7273-7278, 2006 | 217 | 2006 |
The power of imaging to understand extracellular vesicle biology in vivo FJ Verweij, L Balaj, CM Boulanger, DRF Carter, EB Compeer, G D’angelo, ... Nature methods 18 (9), 1013-1026, 2021 | 216 | 2021 |
An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17 L Grine, L Dejager, C Libert, RE Vandenbroucke Cytokine & growth factor reviews 26 (1), 25-33, 2015 | 211 | 2015 |
Amyloid β oligomers disrupt blood–CSF barrier integrity by activating matrix metalloproteinases M Brkic, S Balusu, E Van Wonterghem, N Gorlé, I Benilova, A Kremer, ... Journal of Neuroscience 35 (37), 12766-12778, 2015 | 189 | 2015 |
Passenger mutations confound interpretation of all genetically modified congenic mice TV Berghe, P Hulpiau, L Martens, RE Vandenbroucke, ... Immunity 43 (1), 200-209, 2015 | 186 | 2015 |
Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1 F Van Hauwermeiren, RE Vandenbroucke, C Libert Cytokine & growth factor reviews 22 (5-6), 311-319, 2011 | 184 | 2011 |
A new venue of TNF targeting S Steeland, C Libert, RE Vandenbroucke International journal of molecular sciences 19 (5), 1442, 2018 | 162 | 2018 |
Biodegradable dextran nanogels for RNA interference: focusing on endosomal escape and intracellular siRNA delivery K Raemdonck, B Naeye, K Buyens, RE Vandenbroucke, A Høgset, ... Advanced Functional Materials 19 (9), 1406-1415, 2009 | 158 | 2009 |
Into rather unexplored terrain—Transcellular transport across the blood–brain barrier M De Bock, V Van Haver, RE Vandenbroucke, E Decrock, N Wang, ... Glia 64 (7), 1097-1123, 2016 | 154 | 2016 |