Enhancement of trans-cleavage activity of Cas12a with engineered crRNA enables amplified nucleic acid detection LT Nguyen, BM Smith, PK Jain Nature Communications 11 (1), 4906, 2020 | 241 | 2020 |
Development of Light‐Activated CRISPR Using Guide RNAs with Photocleavable Protectors PK Jain, V Ramanan, AG Schepers, NS Dalvie, A Panda, HE Fleming, ... Angewandte Chemie 128 (40), 12628–12632, 2016 | 181 | 2016 |
Light-activated RNA interference using double-stranded siRNA precursors modified using a remarkable regiospecificity of diazo-based photolabile groups S Shah, PK Jain, A Kala, D Karunakaran, SH Friedman Nucleic acids research 37 (13), 4508-4517, 2009 | 87 | 2009 |
Patterning of gene expression using new photolabile groups applied to light activated RNAi PK Jain, S Shah, SH Friedman Journal of the American Chemical Society 133 (3), 440-446, 2011 | 86 | 2011 |
A thermostable Cas12b from Brevibacillus leverages one-pot discrimination of SARS-CoV-2 variants of concern LT Nguyen, NC Macaluso, BLM Pizzano, MN Cash, J Spacek, J Karasek, ... eBioMedicine - The Lancet 77, 103926, 2022 | 42 | 2022 |
Non-viral delivery of CRISPR/Cas9 complex using CRISPR-GPS nanocomplexes PK Jain, JH Lo, S Rananaware, M Downing, A Panda, M Tai, S Raghavan, ... Nanoscale 11 (44), 21317-21323, 2019 | 39 | 2019 |
Construction of a photoactivated insulin depot PK Jain, D Karunakaran, SH Friedman Angewandte Chemie International Edition 52 (5), 1404-1409, 2013 | 37 | 2013 |
Clinical validation of engineered CRISPR/Cas12a for rapid SARS-CoV-2 detection LT Nguyen, SR Rananaware, BLM Pizzano, BT Stone, PK Jain Communications Medicine - Nature 2 (1), 1-11, 2022 | 35* | 2022 |
Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity JS Dudani, PK Jain, GA Kwong, KR Stevens, SN Bhatia ACS nano 9 (12), 11708-11717, 2015 | 34 | 2015 |
Mesoporous silica nanoparticles: synthesis, properties, and biomedical applications MA Downing, PK Jain Nanoparticles for biomedical applications, 267-281, 2020 | 29 | 2020 |
The synthesis of tetra-modified RNA for the multidimensional control of gene expression via light-activated RNA interference A Kala, PK Jain, D Karunakaran, S Shah, SH Friedman Nature Protocols 9 (1), 11-20, 2014 | 22 | 2014 |
Programmable RNA detection with CRISPR-Cas12a SR Rananaware, EK Vesco, GM Shoemaker, SS Anekar, LSW Sandoval, ... Nature Communications 14, 5409, 2023 | 20 | 2023 |
CRISPR-ENHANCE: An enhanced nucleic acid detection platform using Cas12a LT Nguyen, J Gurijala, SR Rananaware, BLM Pizzano, BT Stone, PK Jain Methods 203, 116-124, 2022 | 15 | 2022 |
A click chemistry amplified nanopore assay for ultrasensitive quantification of HIV-1 p24 antigen in clinical samples X Wei, X Wang, Z Zhang, Y Luo, Z Wang, W Xiong, PK Jain, JR Monnier, ... Nature Communications 13 (1), 6852, 2022 | 14 | 2022 |
Polymerizing Insulin with Photocleavable Linkers to Make Light‐Sensitive Macropolymer Depot Materials BR Sarode, PK Jain, SH Friedman Macromolecular bioscience 16 (8), 1138-1146, 2016 | 14 | 2016 |
Engineering highly thermostable Cas12b via de novo structural analyses for one-pot detection of nucleic acids LT Nguyen, SR Rananaware, LG Yang, NC Macaluso, JE Ocana-Ortiz, ... Cell Reports Medicine 4 (5), 101037, 2023 | 13 | 2023 |
Methods and uses for remotely triggered protease activity measurements SN Bhatia, GA Kwong, PK Jain, JS Dudani, S Schurle US Patent US11428689B2, 2022 | 10 | 2022 |
Harnessing Non-Canonical crRNAs to Improve Functionality of Cas12a Orthologs LT Nguyen, NC Macaluso, NR Rakestraw, DR Carman, BLM Pizzano, ... Cell Reports 43 (2), 113777, 2024 | 9* | 2024 |
Crispr/cas chain reaction systems and methods for amplifying the detection sensitivity of crispr-based target detection SR Rananaware, PK Jain, LT Nguyen, MA Downing US Patent App. 17/928,400, 2023 | 9 | 2023 |
Photocleavable drug conjugates SH Friedman, PK Jain, D Karunakaran, BR Sarode US Patent US10159735B2, 2019 | 8 | 2019 |