| Succinate is an inflammatory signal that induces IL-1β through HIF-1α GM Tannahill, AM Curtis, J Adamik, EM Palsson-McDermott, ... Nature 496 (7444), 238-242, 2013 | 3466 | 2013 |
| A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases RC Coll, AAB Robertson, JJ Chae, SC Higgins, R Muñoz-Planillo, ... Nature medicine 21 (3), 248-255, 2015 | 2318 | 2015 |
| Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes SL Masters, A Dunne, SL Subramanian, RL Hull, GM Tannahill, FA Sharp, ... Nature immunology 11 (10), 897-904, 2010 | 1436 | 2010 |
| Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease SL Masters, A Simon, I Aksentijevich, DL Kastner Annual review of immunology 27, 621-668, 2009 | 1316 | 2009 |
| STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus EF Remmers, RM Plenge, AT Lee, RR Graham, G Hom, TW Behrens, ... New England Journal of Medicine 357 (10), 977-986, 2007 | 1315 | 2007 |
| An autoinflammatory disease with deficiency of the interleukin-1–receptor antagonist I Aksentijevich, SL Masters, PJ Ferguson, P Dancey, J Frenkel, ... New England Journal of Medicine 360 (23), 2426-2437, 2009 | 1044 | 2009 |
| NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice AR Mridha, A Wree, AAB Robertson, MM Yeh, CD Johnson, ... Journal of hepatology 66 (5), 1037-1046, 2017 | 889 | 2017 |
| The B30. 2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1β production JJ Chae, G Wood, SL Masters, K Richard, G Park, BJ Smith, DL Kastner Proceedings of the National Academy of Sciences 103 (26), 9982-9987, 2006 | 735 | 2006 |
| RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL KE Lawlor, N Khan, A Mildenhall, M Gerlic, BA Croker, AA D’Cruz, C Hall, ... Nature communications 6 (1), 6282, 2015 | 609 | 2015 |
| RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis JA Rickard, JA O’Donnell, JM Evans, N Lalaoui, AR Poh, TW Rogers, ... Cell 157 (5), 1175-1188, 2014 | 597 | 2014 |
| TDP-43 triggers mitochondrial DNA release via mPTP to activate cGAS/STING in ALS CH Yu, S Davidson, CR Harapas, JB Hilton, MJ Mlodzianoski, ... Cell 183 (3), 636-649. e18, 2020 | 561 | 2020 |
| The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells A Vasanthakumar, K Moro, A Xin, Y Liao, R Gloury, S Kawamoto, ... Nature immunology 16 (3), 276-285, 2015 | 550 | 2015 |
| Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity PR Nagareddy, M Kraakman, SL Masters, RA Stirzaker, DJ Gorman, ... Cell metabolism 19 (5), 821-835, 2014 | 484 | 2014 |
| Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production M Haneklaus, M Gerlic, M Kurowska-Stolarska, AA Rainey, D Pich, ... The Journal of Immunology 189 (8), 3795-3799, 2012 | 479 | 2012 |
| miR‐223: infection, inflammation and cancer M Haneklaus, M Gerlic, LAJ O'Neill, SL Masters Journal of internal medicine 274 (3), 215-226, 2013 | 448 | 2013 |
| Evidence that TLR4 is not a receptor for saturated fatty acids but mediates lipid-induced inflammation by reprogramming macrophage metabolism GI Lancaster, KG Langley, NA Berglund, HL Kammoun, S Reibe, ... Cell metabolism 27 (5), 1096-1110. e5, 2018 | 400 | 2018 |
| Germline NLRP1 mutations cause skin inflammatory and cancer susceptibility syndromes via inflammasome activation FL Zhong, O Mamaï, L Sborgi, L Boussofara, R Hopkins, K Robinson, ... Cell 167 (1), 187-202. e17, 2016 | 398 | 2016 |
| Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner SA Conos, KW Chen, D De Nardo, H Hara, L Whitehead, G Núñez, ... Proceedings of the National Academy of Sciences 114 (6), E961-E969, 2017 | 396 | 2017 |
| Homeostasis-altering molecular processes as mechanisms of inflammasome activation A Liston, SL Masters Nature Reviews Immunology 17 (3), 208-214, 2017 | 387 | 2017 |
| NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5 PJ Baker, D Boucher, D Bierschenk, C Tebartz, PG Whitney, DB D'Silva, ... European journal of immunology 45 (10), 2918-2926, 2015 | 359 | 2015 |
Daniel KastnerScientific Director, National Human Genome Research Institute, NIH在 mail.nih.gov 的电子邮件经过验证
