| Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions PM Müller, J Rademacher, RD Bagshaw, C Wortmann, C Barth, ... Nature cell biology 22 (4), 498-511, 2020 | 202 | 2020 |
| F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling N Heemskerk, L Schimmel, C Oort, J Van Rijssel, T Yin, B Ma, J Van Unen, ... Nature communications 7 (1), 10493, 2016 | 139 | 2016 |
| A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1 I Timmerman, N Heemskerk, J Kroon, A Schaefer, J van Rijssel, ... Journal of cell science 128 (16), 3041-3054, 2015 | 128 | 2015 |
| Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization J Van Unen, NR Reinhard, T Yin, YI Wu, M Postma, TWJ Gadella, ... Scientific reports 5 (1), 14693, 2015 | 103 | 2015 |
| A New Generation of FRET Sensors for Robust Measurement of Gαi1, Gαi2 and Gαi3 Activation Kinetics in Single Cells J van Unen, AD Stumpf, B Schmid, NR Reinhard, PL Hordijk, C Hoffmann, ... PloS one 11 (1), e0146789, 2016 | 74 | 2016 |
| Different response patterns of several ligands at the sphingosine‐1‐phosphate receptor subtype 3 (S1P3) M Jongsma, J Van Unen, PB Van Loenen, MC Michel, SLM Peters, ... British journal of pharmacology 156 (8), 1305-1311, 2009 | 42 | 2009 |
| A perspective on studying G-protein–coupled receptor signaling with resonance energy transfer biosensors in living organisms J van Unen, J Woolard, A Rinken, C Hoffmann, SJ Hill, J Goedhart, ... Molecular pharmacology 88 (3), 589-595, 2015 | 34 | 2015 |
| A FRET-based biosensor for measuring Gα13 activation in single cells M Mastop, NR Reinhard, CR Zuconelli, F Terwey, TWJ Gadella Jr, ... PLoS One 13 (3), e0193705, 2018 | 33 | 2018 |
| Quantitative single-cell analysis of signaling pathways activated immediately downstream of histamine receptor subtypes J Van Unen, A Rashidfarrokhi, E Hoogendoorn, M Postma, TWJ Gadella, ... Molecular pharmacology 90 (3), 162-176, 2016 | 22 | 2016 |
| Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq J van Unen, T Yin, YI Wu, M Mastop, TWJ Gadella Jr, J Goedhart Scientific Reports 6 (1), 36825, 2016 | 20 | 2016 |
| Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location J Goedhart, J Van Unen, MJW Adjobo-Hermans, TWJ Gadella Jr Scientific reports 3 (1), 2284, 2013 | 18 | 2013 |
| Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells J Goedhart, J van Unen Small GTPases 10 (3), 178-186, 2019 | 12 | 2019 |
| The C-terminus of the oncoprotein TGAT is necessary for plasma membrane association and efficient RhoA-mediated signaling J van Unen, D Botman, T Yin, YI Wu, MA Hink, TWJ Gadella, M Postma, ... BMC Cell Biology 19, 1-15, 2018 | 8 | 2018 |
| Polarity-driven three-dimensional spontaneous rotation of a cell doublet L Lu, T Guyomar, Q Vagne, R Berthoz, A Torres-Sánchez, M Lieb, ... Nature Physics, 1-10, 2024 | 4 | 2024 |
| GTPase activating protein DLC1 spatio-temporally regulates Rho signaling M Heydasch, L Hinderling, J van Unen, M Dobrzynski, O Pertz bioRxiv, 2023.06. 19.545304, 2023 | 3 | 2023 |
| Correction: A FRET-based biosensor for measuring Gα13 activation in single cells M Mastop, NR Reinhard, CR Zuconelli, F Terwey, TWJ Gadella Jr, ... Plos one 13 (4), e0195649, 2018 | 2 | 2018 |
| Palmitoylation of the oncogenic RhoGEF TGAT is dispensable for membrane localization and consequent activation of RhoA J van Unen, D Botman, T Yin, YI Wu, MA Hink, TWJ Gadella Jr, M Postma, ... bioRxiv, 062729, 2016 | 1 | 2016 |
| Spatiotemporal aspects of G protein signaling: Where GPCRs and Rho GTPases meet J van Unen | | 2017 |
| A New Generation of FRET Sensors for Robust Measurement of G [alpha]. sub. i1, G [alpha]. sub. i2 and G [alpha]. sub. i3 Activation Kinetics in Single Cells J van Unen, AD Stumpf, B Schmid, NR Reinhard, PL Hordijk, C Hoffmann, ... PLoS ONE 11 (1), 2016 | | 2016 |
| Identification of Biased Ligands at the mu-Opioid Receptor B Schmid, S Mayer, J van Unen, J Goedhart, T Ozawa, M Brede, ... NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 388, S8-S8, 2015 | | 2015 |
