TOR signaling in growth and metabolism S Wullschleger, R Loewith, MN Hall Cell 124 (3), 471-484, 2006 | 6996 | 2006 |
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive E Jacinto, R Loewith, A Schmidt, S Lin, MA Rüegg, A Hall, MN Hall Nature cell biology 6 (11), 1122-1128, 2004 | 2746 | 2004 |
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control R Loewith, E Jacinto, S Wullschleger, A Lorberg, JL Crespo, D Bonenfant, ... Molecular cell 10 (3), 457-468, 2002 | 2343 | 2002 |
A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling ZA Knight, B Gonzalez, ME Feldman, ER Zunder, DD Goldenberg, ... Cell 125 (4), 733-747, 2006 | 1397 | 2006 |
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2 ME Feldman, B Apsel, A Uotila, R Loewith, ZA Knight, D Ruggero, ... PLoS biology 7 (2), e1000038, 2009 | 1349 | 2009 |
Target of rapamycin (TOR) in nutrient signaling and growth control R Loewith, MN Hall Genetics 189 (4), 1177-1201, 2011 | 994 | 2011 |
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae J Urban, A Soulard, A Huber, S Lippman, D Mukhopadhyay, O Deloche, ... Molecular cell 26 (5), 663-674, 2007 | 925 | 2007 |
The Vam6 GEF controls TORC1 by activating the EGO complex M Binda, MP Peli-Gulli, G Bonfils, N Panchaud, J Urban, TW Sturgill, ... Molecular cell 35 (5), 563-573, 2009 | 512 | 2009 |
Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis A Huber, B Bodenmiller, A Uotila, M Stahl, S Wanka, B Gerrits, ... Genes & development 23 (16), 1929-1943, 2009 | 418 | 2009 |
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast B Bodenmiller, S Wanka, C Kraft, J Urban, D Campbell, PG Pedrioli, ... Science signaling 3 (153), rs4-rs4, 2010 | 374 | 2010 |
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis D Berchtold, M Piccolis, N Chiaruttini, I Riezman, H Riezman, A Roux, ... Nature cell biology 14 (5), 542-547, 2012 | 345 | 2012 |
Molecular organization of target of rapamycin complex 2 S Wullschleger, R Loewith, W Oppliger, MN Hall Journal of Biological Chemistry 280 (35), 30697-30704, 2005 | 322 | 2005 |
The TOR signalling network from yeast to man C De Virgilio, R Loewith The international journal of biochemistry & cell biology 38 (9), 1476-1481, 2006 | 293 | 2006 |
Cell growth control: little eukaryotes make big contributions C De Virgilio, R Loewith Oncogene 25 (48), 6392-6415, 2006 | 276 | 2006 |
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization Y Kamada, Y Fujioka, NN Suzuki, F Inagaki, S Wullschleger, R Loewith, ... Molecular and cellular biology, 2005 | 275 | 2005 |
Systematic analysis of complex genetic interactions E Kuzmin, B VanderSluis, W Wang, G Tan, R Deshpande, Y Chen, M Usaj, ... Science 360 (6386), eaao1729, 2018 | 272 | 2018 |
Caffeine extends yeast lifespan by targeting TORC1 V Wanke, E Cameroni, A Uotila, M Piccolis, J Urban, R Loewith, ... Molecular microbiology 69 (1), 277-285, 2008 | 265 | 2008 |
Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology XL Guan, CM Souza, H Pichler, G Dewhurst, O Schaad, K Kajiwara, ... Molecular biology of the cell 20 (7), 2083-2095, 2009 | 252 | 2009 |
TORC2 structure and function C Gaubitz, M Prouteau, B Kusmider, R Loewith Trends in biochemical sciences 41 (6), 532-545, 2016 | 199 | 2016 |
Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L A Huber, SL French, H Tekotte, S Yerlikaya, M Stahl, MP Perepelkina, ... The EMBO journal 30 (15), 3052-3064, 2011 | 195 | 2011 |