| Oseltamivir (Tamiflu) efflux transport at the blood-brain barrier via P-glycoprotein K Morimoto, M Nakakariya, Y Shirasaka, C Kakinuma, T Fujita, I Tamai, ... Drug Metabolism and Disposition 36 (1), 6-9, 2008 | 124 | 2008 |
| Physiologically‐based pharmacokinetic models for evaluating membrane transporter mediated drug–drug interactions: current capabilities, case studies, future opportunities, and … KS Taskar, V Pilla Reddy, H Burt, MM Posada, M Varma, M Zheng, ... Clinical Pharmacology & Therapeutics 107 (5), 1082-1115, 2020 | 111 | 2020 |
| Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 … M Yoshikawa, M Saitoh, T Katoh, T Seki, SV Bigi, Y Shimizu, T Ishii, ... Journal of medicinal chemistry 61 (6), 2384-2409, 2018 | 98 | 2018 |
| Identification and species similarity of OATP transporters responsible for hepatic uptake of β-lactam antibiotics M Nakakariya, T Shimada, M Irokawa, T Maeda, I Tamai Drug metabolism and pharmacokinetics 23 (5), 347-355, 2008 | 71 | 2008 |
| CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens T Ishii, T Okai, M Iwatani-Yoshihara, M Mochizuki, S Unno, M Kuno, ... Scientific reports 7 (1), 13000, 2017 | 55 | 2017 |
| Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol … K Sato, H Takahagi, T Yoshikawa, S Morimoto, T Takai, K Hidaka, ... Journal of Medicinal Chemistry 58 (9), 3892-3909, 2015 | 42 | 2015 |
| In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes M Nakakariya, M Ono, N Amano, T Moriwaki, K Maeda, Y Sugiyama Drug Metabolism and Disposition 40 (3), 602-609, 2012 | 40 | 2012 |
| Involvement of bile salt export pump in flutamide-induced cholestatic hepatitis T Iwanaga, M Nakakariya, H Yabuuchi, T Maeda, I Tamai Biological and Pharmaceutical Bulletin 30 (4), 739-744, 2007 | 40 | 2007 |
| Predominant contribution of rat organic anion transporting polypeptide-2 (Oatp2) to hepatic uptake of β-lactam antibiotics M Nakakariya, T Shimada, M Irokawa, H Koibuchi, T Iwanaga, ... Pharmaceutical research 25, 578-585, 2008 | 37 | 2008 |
| Organic anion transporter OAT1 is involved in renal handling of citrulline M Nakakariya, Y Shima, Y Shirasaka, K Mitsuoka, T Nakanishi, I Tamai American Journal of Physiology-Renal Physiology 297 (1), F71-F79, 2009 | 35 | 2009 |
| Pharmacological inhibition of monoacylglycerol O-acyltransferase 2 improves hyperlipidemia, obesity, and diabetes by change in intestinal fat utilization K Take, T Mochida, T Maki, Y Satomi, M Hirayama, M Nakakariya, ... PLoS One 11 (3), e0150976, 2016 | 27 | 2016 |
| Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA: monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition … K Sato, H Takahagi, O Kubo, K Hidaka, T Yoshikawa, M Kamaura, ... Bioorganic & Medicinal Chemistry 23 (15), 4544-4560, 2015 | 17 | 2015 |
| A Selective Bombesin Receptor Subtype 3 Agonist Promotes Weight Loss in Male Diet-Induced–Obese Rats With Circadian Rhythm Change Y Nio, N Hotta, M Maruyama, K Hamagami, T Nagi, M Funata, J Sakamoto, ... Endocrinology 158 (5), 1298-1313, 2017 | 15 | 2017 |
| Appropriate risk criteria for OATP inhibition at the drug discovery stage based on the clinical relevancy between OATP inhibitors and drug-induced adverse effect M Nakakariya, A Goto, N Amano Drug Metabolism and Pharmacokinetics 31 (5), 333-339, 2016 | 10 | 2016 |
| Discovery of 1, 8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor T Yukawa, T Nakahata, R Okamoto, Y Ishichi, Y Miyamoto, S Nishimura, ... Bioorganic & Medicinal Chemistry 28 (7), 115376, 2020 | 9 | 2020 |
| Inhibition of MGAT2 modulates fat‐induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high‐fat diet T Mochida, K Take, T Maki, M Nakakariya, R Adachi, K Sato, T Kitazaki, ... FEBS Open Bio 10 (3), 316-326, 2020 | 9 | 2020 |
| Bombesin receptor subtype‐3‐expressing neurons regulate energy homeostasis through a novel neuronal pathway in the hypothalamus M Maruyama, N Hotta, Y Nio, K Hamagami, T Nagi, M Funata, J Sakamoto, ... Brain and Behavior 8 (1), e00881, 2018 | 7 | 2018 |
| Interlaboratory Variability in the Madin–Darby Canine Kidney Cell Proteome MD Harwood, K Zettl, M Weinheimer, V Pilla-Reddy, H Shen, F Jacobs, ... Molecular pharmaceutics 20 (7), 3505-3518, 2023 | 3 | 2023 |
| Recent advances in drug transporter sciences: highlights from the year 2020 PP Chothe, M Nakakariya, CJ Rotter, P Sandoval, K Tohyama Drug Metabolism Reviews 53 (3), 321-349, 2021 | 2 | 2021 |
| Orexin receptor 2 agonist activates diaphragm and genioglossus muscle through stimulating inspiratory neurons in the pre-Bötzinger complex, and phrenic and hypoglossal … R Yamada, T Koike, M Nakakariya, H Kimura PloS one 19 (6), e0306099, 2024 | 1 | 2024 |
Tsuyoshi IshiiNovartis Pharma K.K.在 novartis.com 的电子邮件经过验证
