Microtubule-Stabilizing Activity of Zampanolide, a Potent Macrolide Isolated from the Tongan Marine Sponge Cacospongia mycofijiensis JJ Field, AJ Singh, A Kanakkanthara, T Halafihi, PT Northcote, JH Miller Journal of medicinal chemistry 52 (22), 7328-7332, 2009 | 124 | 2009 |
Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α, β-heterodimers and microtubules JJ Field, B Pera, E Calvo, A Canales, D Zurwerra, C Trigili, ... Chemistry & biology 19 (6), 686-698, 2012 | 105 | 2012 |
Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide JH Miller, AJ Singh, PT Northcote Marine drugs 8 (4), 1059-1079, 2010 | 85 | 2010 |
Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity AJ Singh, CX Xu, X Xu, LM West, A Wilmes, A Chan, E Hamel, JH Miller, ... The Journal of organic chemistry 75 (1), 2-10, 2009 | 64 | 2009 |
Marine Invertebrate Natural Products that Target Microtubules. JH Miller, JJ Field, A Kanakkanthara, JG Owen, AJ Singh, PT Northcote Journal of Natural Products 81, 691-702, 2018 | 54 | 2018 |
Structurally diverse hamigerans from the New Zealand marine sponge Hamigera tarangaensis: NMR-directed isolation, structure elucidation and antifungal activity AJ Singh, JD Dattelbaum, JJ Field, Z Smart, EF Woolly, JM Barber, ... Organic & biomolecular chemistry 11 (46), 8041-8051, 2013 | 39 | 2013 |
The Nitrogenous Hamigerans: Unusual Amino Acid-Derivatized Aromatic Diterpenoid Metabolites from the New Zealand Marine Sponge Hamigera tarangaensis JD Dattelbaum, AJ Singh, JJ Field, JH Miller, PT Northcote The Journal of Organic Chemistry 80 (1), 304-312, 2014 | 35 | 2014 |
Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues AJ Singh, M Razzak, P Teesdale-Spittle, TN Gaitanos, A Wilmes, ... Organic & biomolecular chemistry 9 (12), 4456-4466, 2011 | 29 | 2011 |
Zampanolides B–E from the Marine Sponge Cacospongia mycofijiensis: Potent Cytotoxic Macrolides with Microtubule-Stabilizing Activity T Taufa, AJ Singh, CR Harland, V Patel, B Jones, T Halafihi, JH Miller, ... Journal of natural products 81 (11), 2539-2544, 2018 | 27 | 2018 |
Inhibition of human vascular endothelial cell migration and capillary-like tube formation by the microtubule-stabilizing agent peloruside A A Chan, AJ Singh, PT Northcote, JH Miller Investigational new drugs 33 (3), 564-574, 2015 | 24 | 2015 |
Hamigerans R and S: Nitrogenous Diterpenoids from the New Zealand Marine Sponge Hamigera tarangaensis EF Woolly, AJ Singh, ER Russell, JH Miller, PT Northcote Journal of Natural Products 81 (2), 387-393, 2018 | 19 | 2018 |
Harnessing Natural Product Diversity for Fluorophore Discovery: Naturally Occurring Fluorescent Hydroxyanthraquinones from the Marine Crinoid Pterometra venusta AJ Singh, AP Gorka, HR Bokesch, A Wamiru, BR O’Keefe, ... Journal of Natural Products, 2018 | 17 | 2018 |
Structure of Echivulgarine, a Pyrrolizidine Alkaloid Isolated from the Pollen of Echium vulgare E Cairns, MA Hashmi, AJ Singh, G Eakins, M Lein, R Keyzers Journal of agricultural and food chemistry 63 (33), 7421-7427, 2015 | 17 | 2015 |
Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole KJ Meyer, AJ Singh, A Cameron, AS Tan, DC Leahy, D O’Sullivan, ... Marine drugs 10 (4), 900-917, 2012 | 16 | 2012 |
The protein synthesis inhibitors mycalamides A and E have limited susceptibility toward the drug efflux network V Venturi, C Davies, AJ Singh, JH Matthews, DS Bellows, PT Northcote, ... Journal of biochemical and molecular toxicology 26 (3), 94-100, 2012 | 13 | 2012 |
Peloruside A, a microtubule-stabilizing agent, induces aneuploidy in ovarian cancer cells A Chan, AJ Singh, PT Northcote, JH Miller Investigational new drugs 34 (4), 424-438, 2016 | 7 | 2016 |
Biosynthesis of Nodulisporic Acids: A Multifunctional Monooxygenase Delivers a Complex and Highly Branched Array AT Richardson, RC Cameron, LJ Stevenson, AJ Singh, Y Lukito, D Berry, ... Angewandte Chemie International Edition 61 (49), e202213364, 2022 | 6 | 2022 |
Peloruside E (22-Norpeloruside A), a Pelorusane Macrolide from the New Zealand Marine Sponge Mycale hentscheli, Retains Microtubule-Stabilizing Properties SW Hong, AJ Singh, V Patel, ER Russell, JJ Field, JH Miller, PT Northcote Journal of Natural Products 81 (9), 2125-2128, 2018 | 6 | 2018 |
Generation of Alternate Indole Diterpene Architectures in Two Species of Aspergilli R Bundela, RC Cameron, AJ Singh, RM McLellan, AT Richardson, ... Journal of the American Chemical Society 145 (5), 2754-2758, 2023 | 5 | 2023 |
From Marine Organism to Potential Drug: Using Innovative Techniques to Identify and Characterize Novel Compounds− a Bottom-Up Approach AJ Singh, JJ Field, PH Atkinson, PT Northcote, JH Miller Bioactive Natural Products: Chemistry and Biology, 2015 | 4 | 2015 |