| Cell-signalling dynamics in time and space BN Kholodenko Nature reviews Molecular cell biology 7 (3), 165-176, 2006 | 1646 | 2006 |
| Negative feedback and ultrasensitivity can bring about oscillations in the mitogen‐activated protein kinase cascades BN Kholodenko European journal of biochemistry 267 (6), 1583-1588, 2000 | 836 | 2000 |
| Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades NI Markevich, JB Hoek, BN Kholodenko The Journal of cell biology 164 (3), 353-359, 2004 | 834 | 2004 |
| Quantification of short term signaling by the epidermal growth factor receptor BN Kholodenko, OV Demin, G Moehren, JB Hoek Journal of Biological Chemistry 274 (42), 30169-30181, 1999 | 801 | 1999 |
| Signalling ballet in space and time BN Kholodenko, JF Hancock, W Kolch Nature reviews Molecular cell biology 11 (6), 414-426, 2010 | 717 | 2010 |
| Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance E Aksamitiene, A Kiyatkin, BN Kholodenko Biochemical Society Transactions 40 (1), 139-146, 2012 | 541 | 2012 |
| Untangling the wires: a strategy to trace functional interactions in signaling and gene networks BN Kholodenko, A Kiyatkin, FJ Bruggeman, E Sontag, HV Westerhoff, ... Proceedings of the National Academy of Sciences 99 (20), 12841-12846, 2002 | 499 | 2002 |
| The dynamic control of signal transduction networks in cancer cells W Kolch, M Halasz, M Granovskaya, BN Kholodenko Nature Reviews Cancer 15 (9), 515-527, 2015 | 357 | 2015 |
| Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses MR Birtwistle, M Hatakeyama, N Yumoto, BA Ogunnaike, JB Hoek, ... Molecular systems biology 3 (1), 144, 2007 | 297 | 2007 |
| The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier W Sturm, O. E., Orton, R., Grindlay, J., Birtwistle, M., Vyshemirsky, V ... Sci Signal 3 (153), ra90, 2010 | 292 | 2010 |
| Quantitative analysis of signaling networks HM Sauro, BN Kholodenko Progress in biophysics and molecular biology 86 (1), 5-43, 2004 | 286 | 2004 |
| Why cytoplasmic signalling proteins should be recruited to cell membranes BN Kholodenko, JB Hoek, HV Westerhoff Trends in cell biology 10 (5), 173-178, 2000 | 281 | 2000 |
| Systems‐level interactions between insulin–EGF networks amplify mitogenic signaling N Borisov, E Aksamitiene, A Kiyatkin, S Legewie, J Berkhout, T Maiwald, ... Molecular systems biology 5 (1), 256, 2009 | 272 | 2009 |
| Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics T Nakakuki, MR Birtwistle, Y Saeki, N Yumoto, K Ide, T Nagashima, ... Cell 141 (5), 884-896, 2010 | 268 | 2010 |
| Spatial gradients of cellular phospho-proteins GC Brown, BN Kholodenko FEBS letters 457 (3), 452-454, 1999 | 246 | 1999 |
| Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops A Kiyatkin, E Aksamitiene, NI Markevich, NM Borisov, JB Hoek, ... Journal of biological chemistry 281 (29), 19925-19938, 2006 | 234 | 2006 |
| Inferring dynamic architecture of cellular networks using time series of gene expression, protein and metabolite data E Sontag, A Kiyatkin, BN Kholodenko Bioinformatics 20 (12), 1877-1886, 2004 | 228 | 2004 |
| Evaluating strategies to normalise biological replicates of Western blot data A Degasperi, MR Birtwistle, N Volinsky, J Rauch, W Kolch, ... PloS one 9 (1), e87293, 2014 | 227 | 2014 |
| Frequency modulation of ERK activation dynamics rewires cell fate H Ryu, M Chung, M Dobrzyński, D Fey, Y Blum, SS Lee, M Peter, ... Molecular systems biology 11 (11), 838, 2015 | 217 | 2015 |
| Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors BN Kholodenko Journal of Experimental Biology 206 (12), 2073-2082, 2003 | 212 | 2003 |
Hans WesterhoffUniversity of Amsterdam, VU University Amsterdam, University of Manchester在 manchester.ac.uk 的电子邮件经过验证
