Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways D Grimm, KL Streetz, CL Jopling, TA Storm, K Pandey, CR Davis, ... Nature 441 (7092), 537-541, 2006 | 2100 | 2006 |
Novel tools for production and purification of recombinant adenoassociated virus vectors D Grimm, A Kern, K Rittner, JA Kleinschmidt Human gene therapy 9 (18), 2745-2760, 1998 | 877 | 1998 |
In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses D Grimm, JS Lee, L Wang, T Desai, B Akache, TA Storm, MA Kay Journal of virology 82 (12), 5887-5911, 2008 | 813 | 2008 |
The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9 B Akache, D Grimm, K Pandey, SR Yant, H Xu, MA Kay Journal of virology 80 (19), 9831-9836, 2006 | 556 | 2006 |
Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration Y Malato, S Naqvi, N Schürmann, R Ng, B Wang, J Zape, MA Kay, ... The Journal of clinical investigation 121 (12), 4850-4860, 2011 | 511 | 2011 |
From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy D Grimm, MA Kay Current gene therapy 3 (4), 281-304, 2003 | 453 | 2003 |
DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsids JA King, R Dubielzig, D Grimm, JA Kleinschmidt The EMBO journal 20 (12), 3282-3291, 2001 | 436 | 2001 |
Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6 D Grimm, MA Kay, JA Kleinschmidt Molecular Therapy 7 (6), 839-850, 2003 | 404 | 2003 |
CRISPR/Cas9‐mediated genome engineering: an adeno‐associated viral (AAV) vector toolbox E Senís, C Fatouros, S Große, E Wiedtke, D Niopek, AK Mueller, K Börner, ... Biotechnology journal 9 (11), 1402-1412, 2014 | 337 | 2014 |
Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems P Parameswaran, E Sklan, C Wilkins, T Burgon, MA Samuel, R Lu, ... PLoS pathogens 6 (2), e1000764, 2010 | 303 | 2010 |
Subcellular compartmentalization of adeno-associated virus type 2 assembly A Wistuba, A Kern, S Weger, D Grimm, JA Kleinschmidt Journal of virology 71 (2), 1341-1352, 1997 | 300 | 1997 |
Macrophage microRNA-155 promotes cardiac hypertrophy and failure S Heymans, MF Corsten, W Verhesen, P Carai, REW Van Leeuwen, ... Circulation 128 (13), 1420-1432, 2013 | 280 | 2013 |
Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic JC Giering, D Grimm, TA Storm, MA Kay Molecular therapy 16 (9), 1630-1636, 2008 | 274 | 2008 |
Loss of epigenetic information as a cause of mammalian aging JH Yang, M Hayano, PT Griffin, JA Amorim, MS Bonkowski, ... Cell 186 (2), 305-326. e27, 2023 | 271 | 2023 |
Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver D Grimm, L Wang, JS Lee, N Schürmann, S Gu, K Börner, TA Storm, ... The Journal of clinical investigation 120 (9), 3106-3119, 2010 | 260 | 2010 |
Progress in adeno-associated virus type 2 vector production: promises and prospects for clinical use D Grimm, JA Kleinschmidt Human gene therapy 10 (15), 2445-2450, 1999 | 258 | 1999 |
Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? D Grimm, MA Kay The Journal of clinical investigation 117 (12), 3633-3641, 2007 | 255 | 2007 |
Small silencing RNAs: state-of-the-art D Grimm Advanced drug delivery reviews 61 (9), 672-703, 2009 | 253 | 2009 |
Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy D Grimm, S Zhou, H Nakai, CE Thomas, TA Storm, S Fuess, T Matsushita, ... Blood 102 (7), 2412-2419, 2003 | 251 | 2003 |
Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy L Amoasii, C Long, H Li, AA Mireault, JM Shelton, E Sanchez-Ortiz, ... Science translational medicine 9 (418), eaan8081, 2017 | 244 | 2017 |