| Age-related clonal hematopoiesis associated with adverse outcomes S Jaiswal, P Fontanillas, J Flannick, A Manning, PV Grauman, BG Mar, ... New England Journal of Medicine 371 (26), 2488-2498, 2014 | 4461 | 2014 |
| Highly efficient Cas9-mediated transcriptional programming A Chavez, J Scheiman, S Vora, BW Pruitt, M Tuttle, E PR Iyer, S Lin, ... Nature methods 12 (4), 326-328, 2015 | 1610 | 2015 |
| Comparison of Cas9 activators in multiple species A Chavez, M Tuttle, BW Pruitt, B Ewen-Campen, R Chari, ... Nature methods 13 (7), 563-567, 2016 | 564 | 2016 |
| Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation EAA Nollen, SM Garcia, G Van Haaften, S Kim, A Chavez, RI Morimoto, ... Proceedings of the National Academy of Sciences of the United States of …, 2004 | 511 | 2004 |
| Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform JM Rock, FF Hopkins, A Chavez, M Diallo, MR Chase, ER Gerrick, ... Nature microbiology 2 (4), 1-9, 2017 | 466 | 2017 |
| An enhanced CRISPR repressor for targeted mammalian gene regulation NC Yeo, A Chavez, A Lance-Byrne, Y Chan, D Menn, D Milanova, ... Nature methods 15 (8), 611-616, 2018 | 452 | 2018 |
| A critical role for TCF-1 in T-lineage specification and differentiation BN Weber, AWS Chi, A Chavez, Y Yashiro-Ohtani, Q Yang, O Shestova, ... Nature 476 (7358), 63-68, 2011 | 449 | 2011 |
| Safeguarding CRISPR-Cas9 gene drives in yeast JE DiCarlo, A Chavez, SL Dietz, KM Esvelt, GM Church Nature biotechnology 33 (12), 1250-1255, 2015 | 390 | 2015 |
| Cas9 gRNA engineering for genome editing, activation and repression S Kiani, A Chavez, M Tuttle, RN Hall, R Chari, D Ter-Ovanesyan, J Qian, ... Nature methods 12 (11), 1051-1054, 2015 | 357 | 2015 |
| An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance AC Bester, JD Lee, A Chavez, YR Lee, D Nachmani, S Vora, J Victor, ... Cell 173 (3), 649-664. e20, 2018 | 294 | 2018 |
| Daisy-chain gene drives for the alteration of local populations C Noble, J Min, J Olejarz, J Buchthal, A Chavez, AL Smidler, ... Proceedings of the National Academy of Sciences 116 (17), 8275-8282, 2019 | 243 | 2019 |
| Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir S Iketani, H Mohri, B Culbertson, SJ Hong, Y Duan, MI Luck, ... Nature 613 (7944), 558-564, 2023 | 226 | 2023 |
| sgRNA Scorer 2.0: A species-independent model to predict CRISPR/Cas9 activity R Chari, NC Yeo, A Chavez, GM Church ACS synthetic biology 6 (5), 902-904, 2017 | 226 | 2017 |
| A CRISPR–Cas9-based gene drive platform for genetic interaction analysis in Candida albicans RS Shapiro, A Chavez, CBM Porter, M Hamblin, CS Kaas, JE DiCarlo, ... Nature microbiology 3 (1), 73-82, 2018 | 152 | 2018 |
| Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks R Clarke, R Heler, MS MacDougall, NC Yeo, A Chavez, M Regan, ... Molecular cell 71 (1), 42-55. e8, 2018 | 149 | 2018 |
| Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors S Iketani, F Forouhar, H Liu, SJ Hong, FY Lin, MS Nair, A Zask, Y Huang, ... Nature communications 12 (1), 2016, 2021 | 104 | 2021 |
| CRISPR-based genomic tools for the manipulation of genetically intractable microorganisms RS Shapiro, A Chavez, JJ Collins Nature Reviews Microbiology 16 (6), 333-339, 2018 | 100 | 2018 |
| Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence JM Platt, P Ryvkin, JJ Wanat, G Donahue, MD Ricketts, SP Barrett, ... Genes & development 27 (12), 1406-1420, 2013 | 96 | 2013 |
| High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast X Guo, A Chavez, A Tung, Y Chan, C Kaas, Y Yin, R Cecchi, SL Garnier, ... Nature biotechnology 36 (6), 540-546, 2018 | 94 | 2018 |
| Mutant Cas9 proteins A Chavez, F Poelwijk, GM Church US Patent 9,074,199, 2015 | 76 | 2015 |
George ChurchHarvard Medical School在 harvard.edu 的电子邮件经过验证
