Synthesis and preclinical evaluation of 11C-UCB-J as a PET tracer for imaging the synaptic vesicle glycoprotein 2A in the brain NB Nabulsi, J Mercier, D Holden, S Carré, S Najafzadeh, ... Journal of Nuclear Medicine 57 (5), 777-784, 2016 | 241 | 2016 |
Activity of P-glycoprotein, a β-amyloid transporter at the blood–brain barrier, is compromised in patients with mild Alzheimer disease AK Deo, S Borson, JM Link, K Domino, JF Eary, B Ke, TL Richards, ... Journal of Nuclear Medicine 55 (7), 1106-1111, 2014 | 196 | 2014 |
Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry AK Deo, B Prasad, L Balogh, Y Lai, JD Unadkat Drug Metabolism and Disposition 40 (5), 852-855, 2012 | 94 | 2012 |
Confounding parameters in preclinical assessment of blood–brain barrier permeation: an overview with emphasis on species differences and effect of disease states AK Deo, FP Theil, JM Nicolas Molecular pharmaceutics 10 (5), 1581-1595, 2013 | 91 | 2013 |
Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid AK Deo, SM Bandiera Drug metabolism and disposition 36 (10), 1983-1991, 2008 | 58 | 2008 |
Modulation of P-glycoprotein at the human blood-brain barrier by quinidine or rifampin treatment: a positron emission tomography imaging study L Liu, AC Collier, JM Link, KB Domino, DA Mankoff, JF Eary, ... Drug Metabolism and Disposition 43 (11), 1795-1804, 2015 | 55 | 2015 |
Biotransformation of lithocholic acid by rat hepatic microsomes: metabolite analysis by liquid chromatography/mass spectrometry AK Deo, SM Bandiera Drug metabolism and disposition 36 (2), 442-451, 2008 | 48 | 2008 |
Monooxygenaze, Peroxidaze and Peroxygenase Properties and Mechanisims of Cytochrome P450 M Akbar, AI Archakov, K Auclair, SM Bandera, J Belcher, T Bulko, ... Springer International Publishing, 2015 | 44 | 2015 |
Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep −/− mice E Hrycay, D Forrest, L Liu, R Wang, J Tai, A Deo, V Ling, S Bandiera Molecular and cellular biochemistry 389, 119-132, 2014 | 41 | 2014 |
3-ketocholanoic acid is the major in vitro human hepatic microsomal metabolite of lithocholic acid AK Deo, SM Bandiera Drug metabolism and disposition 37 (9), 1938-1947, 2009 | 39 | 2009 |
Brivaracetam achieves brain SV2A occupancy faster than levetiracetam J Mercier, D Holden, AK Deo Epilepsy Curr 15 (Suppl 1), 343, 2015 | 6 | 2015 |
Regioselective versatility of monooxygenase reactions catalyzed by CYP2B6 and CYP3A4: Examples with single substrates CA Erratico, AK Deo, SM Bandiera Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of …, 2015 | 6 | 2015 |
Antiepileptic Drugs and Chemotherapy: Potential Interactions and Impact on Treatment of Patients With Cancer KL Fink, AK Deo Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and …, 2018 | 1 | 2018 |
Hepatic microsomal bile acid biotransformation: identification of metabolites and cytochrome P450 enzymes involved AK Deo University of British Columbia, 2009 | 1 | 2009 |
Brivaracetam (BRV) Achieves Brain SV2A Occupancy Faster than Levetiracetam (LEV)(S22. 003) J Mercier, D Holden, A Deo, K Fowles, S Kervyn, N Nabulsi, JM Nicolas, ... Neurology 84 (14_supplement), S22. 003, 2015 | | 2015 |
P4‐176: Activity of P‐glycoprotein, an ABC efflux transporter at the blood‐brain barrier, is compromised in Alzheimer's disease A Deo, S Borson, J Link, J Eary, T Richards, D Mankoff, P Hsiao, ... Alzheimer's & Dementia 8 (4S_Part_19), P698-P698, 2012 | | 2012 |
Can P-glycoprotein at the human blood-brain barrier be induced by rifampin? A PET imaging study L Liu, AC Collier, JM Link, KB Domino, JF Eary, DA Mankoff, P Hsiao, ... DRUG METABOLISM REVIEWS 43, 30-31, 2011 | | 2011 |
PET Imaging of P-glycoprotein inhibition at the human blood-brain barrier by quinidine L Liu, AC Collier, JM Link, KB Domino, DA Mankoff, JF Eary, P Hsiao, ... DRUG METABOLISM REVIEWS 43, 207-208, 2011 | | 2011 |
BIOTRANSFORMATION OF BILE ACIDS BY HUMAN LIVER MICROSOMES AK Deo, SM Bandiera DRUG METABOLISM REVIEWS 39, 104-104, 2007 | | 2007 |
Atypical enzyme kinetics and involvement of multiple hepatic cytochrome P450 (CYP) enzymes in lithocholic acid biotransformation AK Deo, SM Bandiera DRUG METABOLISM REVIEWS 38, 69-69, 2006 | | 2006 |