Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs B Hens, Y Tsume, M Bermejo, P Paixao, MJ Koenigsknecht, JR Baker, ... Molecular pharmaceutics 14 (12), 4281-4294, 2017 | 131 | 2017 |
Metabolism of primaquine by liver homogenate fractions: Evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to … L Constantino, P Paixao, R Moreira, MJ Portela, VE Do Rosario, J Iley Experimental and Toxicologic Pathology 51 (4), 299-303, 1999 | 96 | 1999 |
Simple method for determination of paraquat in plasma and serum of human patients by high-performance liquid chromatography P Paixao, P Costa, T Bugalho, C Fidalgo, LM Pereira Journal of Chromatography B 775 (1), 109-113, 2002 | 83 | 2002 |
Prediction of the human oral bioavailability by using in vitro and in silico drug related parameters in a physiologically based absorption model P Paixão, LF Gouveia, JAG Morais International Journal of Pharmaceutics 429 (1-2), 84-98, 2012 | 82 | 2012 |
Prediction of the in vitro permeability determined in Caco-2 cells by using artificial neural networks P Paixão, LF Gouveia, JAG Morais European Journal of Pharmaceutical Sciences 41 (1), 107-117, 2010 | 78 | 2010 |
Prediction of the in vitro intrinsic clearance determined in suspensions of human hepatocytes by using artificial neural networks P Paixão, LF Gouveia, JAG Morais European Journal of Pharmaceutical Sciences 39 (5), 310-321, 2010 | 63 | 2010 |
Prediction of drug distribution within blood P Paixão, LF Gouveia, JAG Morais european journal of pharmaceutical sciences 36 (4), 544-554, 2009 | 56 | 2009 |
Evaluation of dissolution profile similarity–Comparison between the f 2, the multivariate statistical distance and the f 2 bootstrapping methods P Paixão, LF Gouveia, N Silva, JAG Morais European Journal of Pharmaceutics and Biopharmaceutics 112, 67-74, 2017 | 49 | 2017 |
Implementing the Biopharmaceutics Classification System in Drug Development: Reconciling Similarities, Differences, and Shared Challenges in the EMA and US-FDA-Recommended … DB Cardot JM, Garcia Arieta A, Paixao P, Tasevska I AAPS J 18 (4), 1039-46, 2016 | 36 | 2016 |
Prediction of Drug Distribution in Rat and Humans Using an Artificial Neural Networks Ensemble and a PBPK Model P Paixão, N Aniceto, LF Gouveia, JAG Morais Pharmaceutical research 31 (12), 3313-3322, 2014 | 16 | 2014 |
Implementing the additional strength biowaiver for generics: EMA recommended approaches and challenges for a US-FDA submission JM Cardot, AG Arieta, P Paixao, I Tasevska, B Davit European Journal of Pharmaceutical Sciences, 2017 | 10 | 2017 |
Population Approach to Efavirenz Therapy H Duarte, JP Cruz, N Aniceto, AC Ribeiro, A Fernandes, P Paixão, ... Journal of pharmaceutical sciences 106 (10), 3161-3166, 2017 | 10 | 2017 |
Tissue-to-blood distribution coefficients in the rat: Utility for estimation of the volume of distribution in man P Paixão, N Aniceto, LF Gouveia, JAG Morais European Journal of Pharmaceutical Sciences 50 (3-4), 526-543, 2013 | 10 | 2013 |
An alternative single dose parameter to avoid the need for steady-state studies on oral extended-release drug products P Paixão, LF Gouveia, JA Guimarães Morais European Journal of Pharmaceutics and Biopharmaceutics 80 (2), 410-417, 2011 | 9 | 2011 |
In silico prediction of human oral bioavailability: artificial neural networks and physiologically based models P Paixão Lisbon University, 2010 | 2 | 2010 |
Linking Gastrointestinal In Vivo Dissolution and Ibuprofen Systemic Absorption M Bermejo, Y Tsume, P Paixão, B Hens, R Baker, M Koenigsknecht, ... | | 2017 |
Dynamic Change in pH by Low Buffer Capacity of Gastrointestinal Fluids Along The Human Gastrointestinal Tract: Implications For In Vivo Dissolution and Absorption of Ionizable … B Hens, Y Tsume, M Bermejo, P Paixão, M Koenigsknecht, R Baker, ... | | 2017 |
Connecting Gastrointestinal In Vivo Dissolution and Systemic Absorption of Oral Ibuprofen Administered After a Meal P Paixão, M Bermejo, Y Tsume, M Koenigsknecht, B Hens, R Baker, ... | | 2017 |
European Journal of Pharmaceutics and Biopharmaceutics Evaluation of dissolution profile similarity–Comparison between the f 2, the multivariate statistical distance and the f … P Paixão, LF Gouveia, N Silva, JAG Morais | | 2017 |
Pharmacokinetics of vancomycin in intensive-care patients PP Jurij Zdovc, Carla Ferreira Santos, Nuno Silva, José Augusto Guimarães Morais PAGE meeting Lisbon, 2016 | | 2016 |