| The experimental power of FR900359 to study Gq-regulated biological processes R Schrage, AL Schmitz, E Gaffal, S Annala, S Kehraus, D Wenzel, ... Nature communications 6 (1), 10156, 2015 | 352 | 2015 |
| Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B PT Wilder, J Lin, CL Bair, TH Charpentier, D Yang, M Liriano, KM Varney, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1763 (11), 1284-1297, 2006 | 111 | 2006 |
| Structure of Ca2+-Bound S100A4 and Its Interaction with Peptides Derived from Nonmuscle Myosin-IIA VN Malashkevich, KM Varney, SC Garrett, PT Wilder, D Knight, ... Biochemistry 47 (18), 5111-5126, 2008 | 109 | 2008 |
| Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma D Lapadula, E Farias, CE Randolph, TJ Purwin, D McGrath, ... Molecular Cancer Research 17 (4), 963-973, 2019 | 87 | 2019 |
| Divalent metal ion complexes of S100B in the absence and presence of pentamidine TH Charpentier, PT Wilder, MA Liriano, KM Varney, E Pozharski, ... Journal of molecular biology 382 (1), 56-73, 2008 | 66 | 2008 |
| The effects of CapZ peptide (TRTK-12) binding to S100B–Ca2+ as examined by NMR and X-ray crystallography TH Charpentier, LE Thompson, MA Liriano, KM Varney, PT Wilder, ... Journal of molecular biology 396 (5), 1227-1243, 2010 | 61 | 2010 |
| Design of Inhibitors for S100B J Markowitz, AD MacKerell Jr, F Carrier, TH Charpentier, DJ Weber Current Topics in Medicinal Chemistry 5 (12), 1093-1108, 2005 | 60 | 2005 |
| A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation AL Schmitz, R Schrage, E Gaffal, TH Charpentier, J Wiest, ... Chemistry & biology 21 (7), 890-902, 2014 | 58 | 2014 |
| Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes N Hajicek, TH Charpentier, JR Rush, TK Harden, J Sondek Biochemistry 52 (28), 4810-4819, 2013 | 50 | 2013 |
| In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction PT Wilder, TH Charpentier, MA Liriano, K Gianni, KM Varney, E Pozharski, ... International journal of high throughput screening, 109-126, 2010 | 43 | 2010 |
| Membrane-induced allosteric control of phospholipase C-β isozymes TH Charpentier, GL Waldo, MO Barrett, W Huang, Q Zhang, TK Harden, ... Journal of Biological Chemistry 289 (43), 29545-29557, 2014 | 39 | 2014 |
| Small molecules bound to unique sites in the target protein binding cleft of calcium-bound S100B as characterized by nuclear magnetic resonance and X-ray crystallography TH Charpentier, PT Wilder, MA Liriano, KM Varney, S Zhong, A Coop, ... Biochemistry 48 (26), 6202-6212, 2009 | 38 | 2009 |
| Potent and selective peptide-based inhibition of the G protein Gαq TH Charpentier, GL Waldo, EG Lowery-Gionta, K Krajewski, BD Strahl, ... Journal of Biological Chemistry 291 (49), 25608-25616, 2016 | 28 | 2016 |
| Small Molecule Inhibitors of Ca2+-S100B Reveal Two Protein Conformations MC Cavalier, MI Ansari, AD Pierce, PT Wilder, LE McKnight, EP Raman, ... Journal of medicinal chemistry 59 (2), 592-608, 2016 | 20 | 2016 |
| The experimental power of FR900359 to study Gq-regulated biological processes. Nat Commun 6: 10156 R Schrage, AL Schmitz, E Gaffal, S Annala, S Kehraus, D Wenzel, ... | 10 | 2015 |
| Getting a grip on calcium regulation MP Blaustein, TH Charpentier, DJ Weber Proceedings of the National Academy of Sciences 104 (47), 18349-18350, 2007 | 10 | 2007 |
| Hydrocarbon‐Stapled Helices: A Novel Approach for Blocking Protein‐Protein Interactions PT Wilder, TH Charpentier, DJ Weber ChemMedChem: Chemistry Enabling Drug Discovery 2 (8), 1149-1151, 2007 | 5 | 2007 |
| Crystal structure of pentamidine bound to Ca2+-S100B TH Charpentier, PT Wilder, KM Varney, EA Toth, DJ Weber CANCER RESEARCH 66 (8), 2006 | 2 | 2006 |
| Transformation of the carboxyl group of an amino acid to variously substituted imidazoles through a Davidson-type heterocyclization J Kueppers, M Hympanova, T Keuler, AJ Schneider, G Schnakenburg, ... Synthesis 51 (09), 1961-1968, 2019 | 1 | 2019 |
| Methods and compositions for modulating G-alpha-Q signaling J Sondek, TK Harden, GL Waldo, MO Barrett, TH Charpentier US Patent 9,540,620, 2017 | | 2017 |
