Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling CY Janda, LT Dang, C You, J Chang, W De Lau, ZA Zhong, KS Yan, ... Nature 545 (7653), 234-237, 2017 | 324 | 2017 |
A RECK-WNT7 receptor-ligand interaction enables isoform-specific regulation of Wnt bioavailability M Vallon, K Yuki, TD Nguyen, J Chang, J Yuan, D Siepe, Y Miao, M Essler, ... Cell reports 25 (2), 339-349. e9, 2018 | 81 | 2018 |
A human IgSF cell-surface interactome reveals a complex network of protein-protein interactions WM Wojtowicz, J Vielmetter, RA Fernandes, DH Siepe, CL Eastman, ... Cell 182 (4), 1027-1043. e17, 2020 | 74 | 2020 |
Prolyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation D Siepe, S Jentsch nature cell biology 11 (8), 967-972, 2009 | 57 | 2009 |
Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics J Janetzko, R Kise, B Barsi-Rhyne, DH Siepe, FM Heydenreich, ... Cell 185 (24), 4560-4573. e19, 2022 | 46 | 2022 |
Pin1, a novel switch in the ubiquitin pathway S Jentsch, D Siepe Cell Cycle 8 (23), 3800-3801, 2009 | 16 | 2009 |
Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform DH Siepe, LT Henneberg, SC Wilson, GT Hess, MC Bassik, K Zinn, ... Elife 11, e81398, 2022 | 12 | 2022 |
Receptor elimination by E3 ubiquitin ligase recruitment (REULR): a targeted protein degradation toolbox DH Siepe, LK Picton, KC Garcia ACS synthetic biology 12 (4), 1081-1093, 2023 | 10 | 2023 |
Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics J Janetzko, R Kise, B Barsi-Ryne, DH Siepe, FM Heydenreich, ... Biorxiv, 2021.10. 09.463790, 2021 | 8 | 2021 |
Exploring the role of TRPV2 in neuronal development EM Mihelc, DH Siepe, A Chakraborty, M Kalocsay, V Moiseenkova-Bell Biophysical Journal 123 (3), 392a, 2024 | | 2024 |
Receptor elimination by ubiquitin ligase recruitment (REULR) DH Siepe, KC Garcia US Patent WO2022246130A2, 2022 | | 2022 |
The HERCulean E3 Ligase HERC2 safeguards cellular quiescence by regulating the RB/E2F signaling network D Siepe, R Pferdehirt, JR Lill, DS Kirkpatrick, PK Jackson MOLECULAR BIOLOGY OF THE CELL 25, 2014 | | 2014 |
The HERCulean E3 ligase HERC2 acts as a fate switch controlling the RB/E2F signaling network DH Siepe, R Pferdehirt, VG Anania, D Kirkpatrick, PK Jackson FEBS JOURNAL 281, 81-81, 2014 | | 2014 |
Role of the peptidyl-prolyl cis/trans isomerase Pin1 in the ubiquitin proteasome system (UPS) D Siepe lmu, 2009 | | 2009 |