Activated p53 suppresses the histone methyltransferase EZH2 gene X Tang, M Milyavsky, I Shats, N Erez, N Goldfinger, V Rotter Oncogene 23 (34), 5759-5769, 2004 | 254 | 2004 |
Regulation of AIF expression by p53 P Stambolsky, L Weisz, I Shats, Y Klein, N Goldfinger, M Oren, V Rotter Cell Death & Differentiation 13 (12), 2140-2149, 2006 | 236 | 2006 |
p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner A Molchadsky, I Shats, N Goldfinger, M Pevsner-Fischer, M Olson, ... PloS one 3 (11), e3707, 2008 | 217 | 2008 |
p53-dependent down-regulation of telomerase is mediated by p21waf1 I Shats, M Milyavsky, X Tang, P Stambolsky, N Erez, R Brosh, I Kogan, ... Journal of Biological Chemistry 279 (49), 50976-50985, 2004 | 201 | 2004 |
Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype M Milyavsky, I Shats, N Erez, X Tang, S Senderovich, A Meerson, ... Cancer research 63 (21), 7147-7157, 2003 | 191 | 2003 |
Bacteria boost mammalian host NAD metabolism by engaging the deamidated biosynthesis pathway I Shats, JG Williams, J Liu, MV Makarov, X Wu, FB Lih, LJ Deterding, ... Cell metabolism 31 (3), 564-579. e7, 2020 | 158 | 2020 |
Using a stem cell–based signature to guide therapeutic selection in cancer I Shats, ML Gatza, JT Chang, S Mori, J Wang, J Rich, JR Nevins Cancer research 71 (5), 1772-1780, 2011 | 140 | 2011 |
Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1α activation and inhibits tumor growth N Erez, M Milyavsky, R Eilam, I Shats, N Goldfinger, V Rotter Cancer research 63 (24), 8777-8783, 2003 | 128 | 2003 |
hTERT-immortalized prostate epithelial and stromal-derived cells: an authentic in vitro model for differentiation and carcinogenesis I Kogan, N Goldfinger, M Milyavsky, M Cohen, I Shats, G Dobler, ... Cancer research 66 (7), 3531-3540, 2006 | 127 | 2006 |
The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation Y Tabach, M Milyavsky, I Shats, R Brosh, O Zuk, A Yitzhaky, R Mantovani, ... Molecular systems biology 1 (1), 2005.0022, 2005 | 88 | 2005 |
Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect M Milyavsky, I Shats, A Cholostoy, R Brosh, Y Buganim, L Weisz, I Kogan, ... Cancer Cell 11 (2), 133-146, 2007 | 84 | 2007 |
HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer Q Xu, Y Li, X Gao, K Kang, JG Williams, L Tong, J Liu, M Ji, LJ Deterding, ... Nature communications 11 (1), 3978, 2020 | 72 | 2020 |
Transcriptional programs following genetic alterations in p53, INK4A, and H-Ras genes along defined stages of malignant transformation M Milyavsky, Y Tabach, I Shats, N Erez, Y Cohen, X Tang, M Kalis, ... Cancer research 65 (11), 4530-4543, 2005 | 72 | 2005 |
Expression level is a key determinant of E2F1-mediated cell fate I Shats, M Deng, A Davidovich, C Zhang, JS Kwon, D Manandhar, ... Cell Death & Differentiation 24 (4), 626-637, 2017 | 51 | 2017 |
FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function I Shats, ML Gatza, B Liu, SP Angus, L You, JR Nevins Cancer research 73 (19), 6056-6067, 2013 | 51 | 2013 |
CDSeq: A novel complete deconvolution method for dissecting heterogeneous samples using gene expression data K Kang, Q Meng, I Shats, DM Umbach, M Li, Y Li, X Li, L Li PLoS computational biology 15 (12), e1007510, 2019 | 50 | 2019 |
Mutant p53 protects cells from 12-O-tetradecanoylphorbol-13-acetate–induced death by attenuating activating transcription factor 3 induction Y Buganim, E Kalo, R Brosh, H Besserglick, I Nachmany, Y Rais, ... Cancer research 66 (22), 10750-10759, 2006 | 44 | 2006 |
Predicting tumor response to drugs based on gene-expression biomarkers of sensitivity learned from cancer cell lines Y Li, DM Umbach, JM Krahn, I Shats, X Li, L Li BMC genomics 22, 1-18, 2021 | 43 | 2021 |
Activation of p53 protein by telomeric (TTAGGG) n repeats M Milyavsky, A Mimran, S Senderovich, I Zurer, N Erez, I Shats, ... Nucleic acids research 29 (24), 5207-5215, 2001 | 43 | 2001 |
Interaction of E2F7 transcription factor with E2F1 and C-terminal-binding protein (CtBP) provides a mechanism for E2F7-dependent transcription repression B Liu, I Shats, SP Angus, ML Gatza, JR Nevins Journal of Biological Chemistry 288 (34), 24581-24589, 2013 | 36 | 2013 |