| High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening PJ O’Brien, W Irwin, D Diaz, E Howard-Cofield, CM Krejsa, MR Slaughter, ... Archives of toxicology 80, 580-604, 2006 | 700 | 2006 |
| Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy JD Leverson, DC Phillips, MJ Mitten, ER Boghaert, D Diaz, SK Tahir, ... Science translational medicine 7 (279), 279ra40-279ra40, 2015 | 546 | 2015 |
| Glutathione redox potential in response to differentiation and enzyme inducers WG Kirlin, J Cai, SA Thompson, D Diaz, TJ Kavanagh, DP Jones Free Radical Biology and Medicine 27 (11-12), 1208-1218, 1999 | 443 | 1999 |
| A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth T Lau, E Chan, M Callow, J Waaler, J Boggs, RA Blake, S Magnuson, ... Cancer research 73 (10), 3132-3144, 2013 | 341 | 2013 |
| Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential JJ Xu, D Diaz, PJ O’Brien Chemico-biological interactions 150 (1), 115-128, 2004 | 273 | 2004 |
| Hsp90 inhibition decreases mitochondrial protein turnover DH Margineantu, CB Emerson, D Diaz, DM Hockenbery Plos one 2 (10), e1066, 2007 | 157 | 2007 |
| Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice JC Ullman, A Arguello, JA Getz, A Bhalla, CS Mahon, J Wang, T Giese, ... Science Translational Medicine 12 (545), eaay1163, 2020 | 150 | 2020 |
| Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an … JF Blake, M Burkard, J Chan, H Chen, KJ Chou, D Diaz, DA Dudley, ... Journal of medicinal chemistry 59 (12), 5650-5660, 2016 | 144 | 2016 |
| Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease D Jennings, S Huntwork-Rodriguez, AG Henry, JC Sasaki, R Meisner, ... Science translational medicine 14 (648), eabj2658, 2022 | 125 | 2022 |
| Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic T Logan, MJ Simon, A Rana, GM Cherf, A Srivastava, SS Davis, RLY Low, ... Cell 184 (18), 4651-4668. e25, 2021 | 125 | 2021 |
| Effect of dietary inducer dimethylfumarate on glutathione in cultured human retinal pigment epithelial cells KC Nelson, JL Carlson, ML Newman, P Sternberg, DP Jones, ... Investigative ophthalmology & visual science 40 (9), 1927-1935, 1999 | 122 | 1999 |
| Targeting of beta adrenergic receptors results in therapeutic efficacy against models of hemangioendothelioma and angiosarcoma JM Stiles, C Amaya, S Rains, D Diaz, R Pham, J Battiste, JF Modiano, ... PloS one 8 (3), e60021, 2013 | 115 | 2013 |
| Evaluation of an automated in vitro micronucleus assay in CHO-K1 cells D Diaz, A Scott, P Carmichael, W Shi, C Costales Mutation Research/Genetic Toxicology and Environmental Mutagenesis 630 (1-2 …, 2007 | 111 | 2007 |
| Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor L Wang, GA Doherty, AS Judd, ZF Tao, TM Hansen, RR Frey, X Song, ... ACS medicinal chemistry letters 11 (10), 1829-1836, 2020 | 91 | 2020 |
| Tankyrase inhibition causes reversible intestinal toxicity in mice with a therapeutic index< 1 Y Zhong, P Katavolos, T Nguyen, T Lau, J Boggs, A Sambrone, D Kan, ... Toxicologic pathology 44 (2), 267-278, 2016 | 88 | 2016 |
| A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models B van Lengerich, L Zhan, D Xia, D Chan, D Joy, JI Park, D Tatarakis, ... Nature neuroscience 26 (3), 416-429, 2023 | 84 | 2023 |
| Induction of glutamate-cysteine ligase (γ-glutamylcysteine synthetase) in the brains of adult female mice subchronically exposed to methylmercury SA Thompson, CC White, CM Krejsa, D Diaz, JS Woods, DL Eaton, ... Toxicology letters 110 (1-2), 1-9, 1999 | 73 | 1999 |
| Chemically diverse group I p21-activated kinase (PAK) inhibitors impart acute cardiovascular toxicity with a narrow therapeutic window J Rudolph, LJ Murray, CO Ndubaku, T O’Brien, E Blackwood, W Wang, ... Journal of medicinal chemistry 59 (11), 5520-5541, 2016 | 66 | 2016 |
| Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme A Arguello, CS Mahon, MEK Calvert, D Chan, JC Dugas, ME Pizzo, ... Journal of Experimental Medicine 219 (3), e20211057, 2022 | 46 | 2022 |
| Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology RI Erickson, J Tarrant, G Cain, SC Lewin-Koh, N Dybdal, H Wong, ... Toxicological Sciences 131 (1), 247-258, 2013 | 45 | 2013 |
