| Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients SJ Howe, MR Mansour, K Schwarzwaelder, C Bartholomae, M Hubank, ... The Journal of clinical investigation 118 (9), 2008 | 1456 | 2008 |
| New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling WA Dik, K Pike-Overzet, F Weerkamp, D De Ridder, EFE De Haas, ... The Journal of experimental medicine 201 (11), 1715-1723, 2005 | 462 | 2005 |
| Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia I Homminga, R Pieters, AW Langerak, JJ de Rooi, A Stubbs, M Verstegen, ... Cancer cell 19 (4), 484-497, 2011 | 405 | 2011 |
| Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy A Deichmann, S Hacein-Bey-Abina, M Schmidt, A Garrigue, MH Brugman, ... The Journal of clinical investigation 117 (8), 2225-2232, 2007 | 298 | 2007 |
| Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo K Schwarzwaelder, SJ Howe, M Schmidt, MH Brugman, A Deichmann, ... The Journal of clinical investigation 117 (8), 2241-2249, 2007 | 242 | 2007 |
| New insights and unresolved issues regarding insertional mutagenesis in X-linked SCID gene therapy K Pike-Overzet, M Van Der Burg, G Wagemaker, JJ Van Dongen, ... Molecular Therapy 15 (11), 1910-1916, 2007 | 129 | 2007 |
| Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity R Bijkerk, C van Solingen, HC de Boer, P van der Pol, M Khairoun, ... Journal of the American society of nephrology 25 (8), 1710-1722, 2014 | 115 | 2014 |
| T-, B-and NK-lymphoid, but not myeloid cells arise from human CD34+CD38−CD7+ common lymphoid progenitors expressing lymphoid-specific genes I Hoebeke, M De Smedt, F Stolz, K Pike-Overzet, FJT Staal, J Plum, ... Leukemia 21 (2), 311-319, 2007 | 105 | 2007 |
| Retroviral vector insertion sites associated with dominant hematopoietic clones mark “stemness” pathways OS Kustikova, H Geiger, Z Li, MH Brugman, SM Chambers, CA Shaw, ... Blood 109 (5), 1897-1907, 2007 | 102 | 2007 |
| Ex vivo expansion of hematopoietic stem cells for therapeutic purposes: lessons from development and the niche P Tajer, K Pike-Overzet, S Arias, M Havenga, FJT Staal Cells 8 (2), 169, 2019 | 97 | 2019 |
| Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer K Pike-Overzet, M Rodijk, YY Ng, MRM Baert, C Lagresle-Peyrou, ... Leukemia 25 (9), 1471-1483, 2011 | 93 | 2011 |
| Aberrant Wnt signaling in leukemia FJT Staal, F Famili, L Garcia Perez, K Pike-Overzet Cancers 8 (9), 78, 2016 | 90 | 2016 |
| Ectopic retroviral expression of LMO2, but not IL2Rγ, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy K Pike-Overzet, D de Ridder, F Weerkamp, MRM Baert, MMA Verstegen, ... Leukemia 21 (4), 754-763, 2007 | 89 | 2007 |
| Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia S Rahman, M Magnussen, TE León, N Farah, Z Li, BJ Abraham, KZ Alapi, ... Blood, The Journal of the American Society of Hematology 129 (24), 3221-3226, 2017 | 80 | 2017 |
| Inflammation and Wnt signaling: target for immunomodulatory therapy? I Jridi, K Canté-Barrett, K Pike-Overzet, FJT Staal Frontiers in cell and developmental biology 8, 615131, 2021 | 78 | 2021 |
| Is IL2RG oncogenic in T-cell development? K Pike-Overzet, D de Ridder, F Weerkamp, MRM Baert, MM Verstegen, ... Nature 443 (7109), E5-E5, 2006 | 72 | 2006 |
| T-sing progenitors to commit F Weerkamp, K Pike-Overzet, FJT Staal Trends in immunology 27 (3), 125-131, 2006 | 72 | 2006 |
| Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in man RW Hendriks, RGM Bredius, K Pike-Overzet, FJT Staal Expert opinion on therapeutic targets 15 (8), 1003-1021, 2011 | 69 | 2011 |
| Isolation of human and mouse hematopoietic stem cells YY Ng, MRM Baert, EFE de Haas, K Pike-Overzet, FJT Staal Genetic Modification of Hematopoietic Stem Cells: Methods and Protocols, 13-21, 2009 | 52 | 2009 |
| Sola dosis facit venenum. Leukemia in gene therapy trials: a question of vectors, inserts and dosage? FJT Staal, K Pike-Overzet, YY Ng, JJM van Dongen Leukemia 22 (10), 1849-1852, 2008 | 52 | 2008 |
