Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia CM Metallo, PA Gameiro, EL Bell, KR Mattaini, J Yang, K Hiller, ... Nature 481 (7381), 380-384, 2012 | 1927 | 2012 |
Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles A Verma, O Uzun, Y Hu, Y Hu, HS Han, N Watson, S Chen, DJ Irvine, ... Nature materials 7 (7), 588-595, 2008 | 1445 | 2008 |
Bio-inspired, bioengineered and biomimetic drug delivery carriers JW Yoo, DJ Irvine, DE Discher, S Mitragotri Nature reviews Drug discovery 10 (7), 521-535, 2011 | 1308 | 2011 |
Direct observation of ligand recognition by T cells DJ Irvine, MA Purbhoo, M Krogsgaard, MM Davis Nature 419 (6909), 845-849, 2002 | 1018 | 2002 |
Structure-based programming of lymph-node targeting in molecular vaccines H Liu, KD Moynihan, Y Zheng, GL Szeto, AV Li, B Huang, DS Van Egeren, ... Nature 507 (7493), 519-522, 2014 | 903 | 2014 |
Synthetic nanoparticles for vaccines and immunotherapy DJ Irvine, MC Hanson, K Rakhra, T Tokatlian Chemical reviews 115 (19), 11109-11146, 2015 | 770 | 2015 |
Therapeutic cell engineering with surface-conjugated synthetic nanoparticles MT Stephan, JJ Moon, SH Um, A Bershteyn, DJ Irvine Nature medicine 16 (9), 1035-1041, 2010 | 749 | 2010 |
T cell killing does not require the formation of a stable mature immunological synapse MA Purbhoo, DJ Irvine, JB Huppa, MM Davis Nature immunology 5 (5), 524-530, 2004 | 660 | 2004 |
Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses JJ Moon, H Suh, A Bershteyn, MT Stephan, H Liu, B Huang, M Sohail, ... Nature materials 10 (3), 243-251, 2011 | 618 | 2011 |
Enhancing cancer immunotherapy with nanomedicine DJ Irvine, EL Dane Nature Reviews Immunology 20 (5), 321-334, 2020 | 597 | 2020 |
Engineering synthetic vaccines using cues from natural immunity DJ Irvine, MA Swartz, GL Szeto Nature materials 12 (11), 978-990, 2013 | 580 | 2013 |
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses KD Moynihan, CF Opel, GL Szeto, A Tzeng, EF Zhu, JM Engreitz, ... Nature medicine 22 (12), 1402-1410, 2016 | 543 | 2016 |
Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery L Tang, Y Zheng, MB Melo, L Mabardi, AP Castaño, YQ Xie, N Li, ... Nature biotechnology 36 (8), 707-716, 2018 | 527 | 2018 |
Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus LY Koo, DJ Irvine, AM Mayes, DA Lauffenburger, LG Griffith Journal of cell science 115 (7), 1423-1433, 2002 | 526 | 2002 |
A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples ME Ackerman, B Moldt, RT Wyatt, AS Dugast, E McAndrew, S Tsoukas, ... Journal of immunological methods 366 (1-2), 8-19, 2011 | 456 | 2011 |
Engineering nano‐and microparticles to tune immunity JJ Moon, B Huang, DJ Irvine Advanced materials 24 (28), 3724-3746, 2012 | 450 | 2012 |
T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity D Schmid, CG Park, CA Hartl, N Subedi, AN Cartwright, RB Puerto, ... Nature communications 8 (1), 1747, 2017 | 407 | 2017 |
Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction JJ Moon, H Suh, AV Li, CF Ockenhouse, A Yadava, DJ Irvine Proceedings of the National Academy of Sciences 109 (4), 1080-1085, 2012 | 391 | 2012 |
In Vitro and in Vivo mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles X Su, J Fricke, DG Kavanagh, DJ Irvine Molecular pharmaceutics 8 (3), 774-787, 2011 | 391 | 2011 |
HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies JM Steichen, DW Kulp, T Tokatlian, A Escolano, P Dosenovic, ... Immunity 45 (3), 483-496, 2016 | 378 | 2016 |