A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity S Khan, X Zhang, D Lv, Q Zhang, Y He, P Zhang, X Liu, D Thummuri, ... Nature medicine 25 (12), 1938-1947, 2019 | 437 | 2019 |
Self‐treatment of opioid withdrawal using kratom (Mitragynia speciosa korth) EW Boyer, KM Babu, JE Adkins, CR McCurdy, JH Halpern Addiction 103 (6), 1048-1050, 2008 | 394 | 2008 |
Opioid receptors and legal highs: Salvia divinorum and Kratom KM Babu, CR McCurdy, EW Boyer Clinical toxicology 46 (2), 146-152, 2008 | 309 | 2008 |
Analgesic substances derived from natural products (natureceuticals) CR McCurdy, SS Scully Life sciences 78 (5), 476-484, 2005 | 181 | 2005 |
Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist CR McCurdy, KJ Sufka, GH Smith, JE Warnick, MJ Nieto Pharmacology Biochemistry and Behavior 83 (1), 109-113, 2006 | 163 | 2006 |
Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate … N Singh, G Cheve, MA Avery, CR McCurdy Current pharmaceutical design 13 (11), 1161-1177, 2007 | 158 | 2007 |
Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7‐hydroxymitragynine SE Hemby, S McIntosh, F Leon, SJ Cutler, CR McCurdy Addiction biology 24 (5), 874-885, 2019 | 153 | 2019 |
p-Hydroxyphenylpyruvate dioxygenase is a herbicidal target site for β-triketones from Leptospermum scoparium FE Dayan, SO Duke, A Sauldubois, N Singh, C McCurdy, C Cantrell Phytochemistry 68 (14), 2004-2014, 2007 | 147 | 2007 |
Investigation of the adrenergic and opioid binding affinities, metabolic stability, plasma protein binding properties, and functional effects of selected indole-based kratom … S Obeng, SH Kamble, ME Reeves, LF Restrepo, A Patel, M Behnke, ... Journal of medicinal chemistry 63 (1), 433-439, 2019 | 113 | 2019 |
Suspected adulteration of commercial kratom products with 7-hydroxymitragynine AG Lydecker, A Sharma, CR McCurdy, BA Avery, KM Babu, EW Boyer Journal of Medical Toxicology 12, 341-349, 2016 | 113 | 2016 |
The sigma-2 receptor and progesterone receptor membrane component 1 are different binding sites derived from independent genes UB Chu, TA Mavlyutov, ML Chu, H Yang, A Schulman, C Mesangeau, ... EBioMedicine 2 (11), 1806-1813, 2015 | 113 | 2015 |
Herbal medicines for the management of opioid addiction: safe and effective alternatives to conventional pharmacotherapy? J Ward, C Rosenbaum, C Hernon, CR McCurdy, EW Boyer CNS drugs 25, 999-1007, 2011 | 111 | 2011 |
Phytochemical Characterization of the Leaves of Mitragyna Speciosa Grown in USA F León, E Habib, JE Adkins, EB Furr, CR McCurdy, SJ Cutler Natural Product Communications 4 (7), 1934578X0900400705, 2009 | 101 | 2009 |
Kratom policy: the challenge of balancing therapeutic potential with public safety WC Prozialeck, BA Avery, EW Boyer, O Grundmann, JE Henningfield, ... International Journal of Drug Policy 70, 70-77, 2019 | 100 | 2019 |
New positron emission tomography (PET) radioligand for imaging σ-1 receptors in living subjects ML James, B Shen, CL Zavaleta, CH Nielsen, C Mesangeau, PK Vuppala, ... Journal of medicinal chemistry 55 (19), 8272-8282, 2012 | 99 | 2012 |
Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom) SH Kamble, A Sharma, TI King, F León, CR McCurdy, BA Avery Xenobiotica, 2019 | 98 | 2019 |
Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis L Garcés-Ramírez, JL Green, T Hiranita, TA Kopajtic, M Mereu, ... Biological psychiatry 69 (3), 208-217, 2011 | 98 | 2011 |
The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats WC Hong, H Yano, T Hiranita, FT Chin, CR McCurdy, TP Su, SG Amara, ... Journal of Biological Chemistry 292 (27), 11250-11261, 2017 | 88 | 2017 |
Evaluation of phytocannabinoids from high-potency Cannabis sativa using in vitro bioassays to determine structure–activity relationships for cannabinoid receptor 1 … AS Husni, CR McCurdy, MM Radwan, SA Ahmed, D Slade, SA Ross, ... Medicinal Chemistry Research 23, 4295-4300, 2014 | 84 | 2014 |
N-naphthoyl-β-naltrexamine (NNTA), a highly selective and potent activator of μ/κ-opioid heteromers AS Yekkirala, MM Lunzer, CR McCurdy, MD Powers, AE Kalyuzhny, ... Proceedings of the National Academy of Sciences 108 (12), 5098-5103, 2011 | 84 | 2011 |